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口腔黏膜二氧化碳分压与大鼠失血性休克程度的相关性研究

DOI: 10.1360/052011-572, PP. 992-999

Keywords: 口腔黏膜二氧化碳分压(PbuCO2),失血,休克,组织灌注

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Abstract:

通过研究大鼠失血过程中口腔黏膜二氧化碳分压(PbuCO2)与失血性休克程度的相关性,证明PbuCO2可用于失血性休克早期救治过程中休克程度的评价.25只Wistar大鼠随机分成5组,用戊巴比妥钠麻醉后,除假手术组外,其余4组失血30min,失血量分别达到总血容量的25%,30%,35%和40%.用PbuCO2检测装置对大鼠口腔黏膜的PCO2进行连续、无创检测,并对动脉血压(ABP)、心输出量(CO)、心电(ECG)和呼吸(RES)进行实时或不间断的检测,另外不间断抽取动脉血进行血液检验.失血后30min时,除40%小组部分动物死亡外,其余存活动物的ABP,CO,ECG,RES,血气和电解质都没有显著差异,而仅失血15min后,相对上述生理指标,PbuCO2表现出极显著的差异性(P<0.01).实验证明,PbuCO2不仅能够检测失血后组织灌注的变化,而且与ABP,CO,血气和电解质等指标相比,在区分不同程度的休克时更具有一致性、准确性和灵敏性.结果显示,PbuCO2的连续无创检测可有效地评价失血性休克程度,指导早期救治.

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