2 Degterev A, Hitomi J, Germscheid M, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol, 2008, 4: 313–321？？
[2]
3 Ramnarain D B, Paulmurugan R, Park S, et al. RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Cell Death Differ, 2008, 15: 344–353？？
[3]
4 Navas T A, Baldwin D T, Stewart T A. RIP2 is a Raf1-activated mitogen-activated protein kinase kinase. J Biol Chem, 1999, 274: 33684–33690？？
[4]
5 McCarthy J V, Ni J, Dixit V M. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. J Biol Chem, 1998, 273: 16968–16975？？
7 Zhang H, Zhang R, Lin Y, et al. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem, 2007, 282: 14788–14796？？
[7]
8 Izumi K M, Cahir M E, Ting A T, et al. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. Mol Cell Biol, 1999, 19: 5759–5767
[8]
1 Zhang D, Lin J, Han J. Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol, 2010, 7: 243–249？？
[9]
9 Komada Y, Inaba H, Zhou Y W, et al. mRNA expression of Fas receptor (CD95)-associated proteins (Fas-associated phosphatase-1/FAP-1, Fas-associating protein with death domain/FADD, and receptor-interacting protein/RIP) in human leukaemia/lymphoma cell lines. Br J Haematol, 1997, 99: 325–330？？
[10]
10 Poyet J L, Srinivasula S M, Lin J H, et al. Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem, 2000, 275: 37966–37977？？
[11]
11 Meylan E, Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci, 2005, 30: 151–159？？
[12]
12 Shikama Y, Yamada M, Miyashita T. Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases. Eur J Immunol, 2003, 33: 1998–2006？？
[13]
13 Devin A, Lin Y, Liu Z G. The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep, 2003, 4: 623–627？？
[14]
14 Sun X, Lee J, Navas T, et al. RIP3, a novel apoptosis-inducing kinase. J Biol Chem, 1999, 274: 16871–16875？？
[15]
15 Yu P W, Huang B C, Shen M, et al. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol, 1999, 9: 539–542？？
[16]
16 Pazdernik N J, Donner D B, Goebl M G, et al. Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol, 1999, 19: 6500–6508
[17]
17 Yang Y, Hu W, Feng S, et al. RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. Biochem Biophys Res Commun, 2005, 332: 181–187
[18]
18 Kasof G M, Prosser J C, Liu D, et al. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett, 2000, 473: 285–291
[19]
19 Yang Y, Ma J, Chen Y, et al. Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. J Biol Chem, 2004, 279: 38820–38829？？
[20]
20 Xu Y, Zhao X H. RIP3: a possible trigger of apoptosis or necrosis. Prog Biochem Biophys, 2010, 37: 1067–1073？？
[21]
21 Li M, Feng S, Wu M. Multiple roles for nuclear localization signal (NLS, aa 442-472) of receptor interacting protein 3 (RIP3). Biochem Biophys Res Commun, 2008, 372: 850–855
[22]
22 Sun X, Yin J, Starovasnik M A, et al. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J Biol Chem, 2002, 277: 9505–9511？？
24 Kasof G M, Prosser J C, Liu D, et al. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett, 2000, 473: 285–291
[25]
25 Zhang D W, Shao J, Lin J, et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 2009, 325: 332–336？？
[26]
26 Mucha E, Hoefle C, Huckelhoven R, et al. RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules. Eur J Cell Biol, 2010, 89: 906–916？？
[27]
27 Feng S, Yang Y, Mei Y, et al. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal, 2007, 19: 2056–2067？？
[28]
28 Kaiser W J, Offermann M K. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol, 2005, 174: 4942–4952
[29]
29 He S D, Wang L, Miao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell, 2009, 137: 1100–1111？？
[30]
30 Newton K, Sun X, Dixit V M. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol, 2004, 24: 1464–1469
[31]
31 Rebsamen M, Heinz L X, Meylan E, et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep, 2009, 10: 916–922？？
[32]
32 Wrighton K H. Cell death: a killer puts a stop on necroptosis. Nat Rev Mol Cell Biol, 2011, 12: 279？？
[33]
33 Vandenabeele P, Galluzzi L, Vanden B T, et al. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol, 2010, 11: 700–714？？
[34]
35 Berghe T V, Vanlangenakker N, Parthoens E, et al. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ, 2010, 17: 922–930？？
37 Miao B, Degterev A. Methods to analyze cellular necroptosis. Methods Mol Biol, 2009, 559: 79–93？？
[37]
38 Cho Y S, Challa S, Moquin D, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell, 2009, 137: 1112–1123？？
[38]
39 Cho Y, Challa S, Chan F K. A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. Adv Exp Med Biol, 2011, 691: 589–593？？
[39]
40 Declercq W, Vanden B T, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell, 2009, 138: 229–232？？
[40]
41 Wilkins K A, Bancroft J, Bosch M, et al. ROS and NO mediate actin reorganization and programmed cell death in the Self-Incompatibility response of Papaver. Plant Physiol, 2011, 156: 404–416？？
[41]
42 Li Y, Rory G C, Sang Y, et al. Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. Anticancer Drugs, 2009, 20: 770–778？？
[42]
43 Liu W H, Cheng Y C, Chang L S. ROS-mediated p38alpha MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A(2)-treated U937 cells. J Cell Physiol, 2009, 219: 642–651？？
[43]
44 Kim H S, Loughran P A, Rao J, et al. Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes. Am J Physiol Gastrointest Liver Physiol, 2008, 295: G146–G152？？
[44]
45 Byun H S, Park K A, Won M, et al. Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: implication for the regulatory role of protein kinase C. Mol Pharmacol, 2006, 70: 1099–1108？？
[45]
46 Vanlangenakker N, Vanden B T, Bogaert P, et al. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ, 2011, 18: 656–665？？
[46]
47 Galluzzi L, Kepp O, Kroemer G. RIP kinases initiate programmed necrosis. J Mol Cell Biol, 2009, 1: 1, 8–10？？
[47]
48 Zhang D W, Zheng M, Zhao J, et al. Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes. Cell Res, 2011, 21: 368–371？？
[48]
49 Vandenabeele P, Declercq W, Van Herreweghe F, et al. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal, 2010, 3: re4
[49]
50 Moquin D, Chan F K. The molecular regulation of programmed necrotic cell injury. Trends Biochem Sci, 2010, 35: 434–441？？
[50]
51 Davis C W, Hawkins B J, Ramasamy S, et al. Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med, 2010, 48: 306–317？？
[51]
52 Kaiser W J, Upton J W, Long A B, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature, 2011, 471: 368–372？？
[52]
53 Vandenabeele P, Galluzzi L, Vanden B T, et al. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol, 2010, 11: 700–714？？
[53]
54 Upton J W, Kaiser W J, Mocarski E S. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe, 2010, 7: 302–313？？
[54]
55 Cerhan J R, Ansell S M, Fredericksen Z S, et al. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. Blood, 2007, 110: 4455–4463？？
[55]
34 Christofferson D E, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol, 2010, 22: 263–268？？
