1 Blake A, Jones M, Darwish A, et al. Antibody-based sensors for heavy metal ions. Biosens Bioelectron, 2001, 16: 799–809？？
[2]
2 Devi M, Lu D, Carlson D, et al. Inhibition of acetylcholinesterase activity in the central nervous system of the red swamp crayfish, Procambarus clarkia, by mercury, cadmium, and lead. Bull Enviro Contamin Toxicol, 1995, 55: 746–750
[3]
3 Ireland P. Heavy Metal Sources–Uptake and Distribution. In: Dillon H K, Ho M H, eds. Biological Monitoring of Heavy Metals. New York: Wiley, 1991. 263
[4]
4 Avitsin P, Zhavoronkov A, Rish A, et al. Human Microelementoses. Moscow: Meditsina, 1991
[5]
5 Gismers J, Hueso D, Procopio R, et al. Ion-selective carbon paste electrode based on tetraethyl thiuram disulfide for copper and mercury. Anal Chim Acta, 2004, 524: 347–353？？
[6]
6 Yalow R S, Berson S A. Immunoassay of endogenous plasma insulin in man. J Clin Invest, 1960, 39: 1157–1175？？
[7]
7 Blake A, Blake II C, Khosraviani M, et al. Immunoassays for metal ions. Anal Chim Acta, 1998, 376: 13–19？？
[8]
8 Allen B, Sittonen H, Thompson C, et al. Methods for the determination of arsenic, cadmium, copper, lead, and tin in sucrose, corn syrups, and high-fructose corn syrups by inductively coupled plasma atomic emission spectrometry. J Agricult Food Chem,1997, 45: 162–165？？
[9]
9 Blake A, Dawson N, Chakravarti P, et al. Environmental Immunochemical Methods: Perspectives and Applications. Washington D.C.: American Chemistry Society, 1996. 10
[10]
10 Blake A, Chakrabarti P, Hatcher M, et al. Metal binding properties of a monoclonal antibody directed toward metal-chelate complex. J Biol Chem, 1996, 271: 27677–27685？？
[11]
11 Lerner A, Benkovic J, Schultz G, et al. At the crossroads of chemistry and immunology catalytic antibodies. Science, 1991, 252: 659–667？？
[12]
12 Love A, Villafranca E, Aust M, et al. How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab’/ hapten complexes with different metals in the chelate. Biochem, 1993, 32: 10950–10959？？
[13]
13 Wylie E, Carlson D, Carlson R, et al. Detection of mercuric ions in water by ELISA with a mercury specific antibody. Anal Biochem, 1991, 194: 381–387？？
[14]
14 Wylie E, Lu D, Carlson D, et al. Immunology, monoclonal antibodies specific for mercuric ions. Proc Natl Acad Sci USA, 1992, 89: 4104–4108？？
[15]
15 Meares F, Mccall J, Reardan T, et al. Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions. Anal Biochem, 1984, 142: 68–78？？
[16]
16 Meares F. Chelating agents for the binding of metal ions to antibodies. Int J Rad Appl Instru B, 1986, 13: 311
[17]
17 Moi K, Meares F, Denardo J, et al. Copper chelates as probes of biological systems: stable copper complexes with a macrocyclic bifunctional chelating agent. Anal Biochem, 1985, 148: 249–253？？
[18]
18 Reardan T, Meares F, Frincke M, et al. Antibodies against metal chelates. Nature, 1985, 316: 265–268？？
[19]
19 Mukkala M, Mikola H, Hemmil I, et al. The synthesis and use of activated N-benzyl derivatives of diethylenetriaminetetraacetic acids: alternative reagents for labeling of antibodies with metal ions. Anal Biochem, 1989, 176: 319–325？？
[20]
20 Blake A, Jones M, Yu N, et al. Antibody-based sensors for heavy metal ions. Biosens Bioelectron, 2001, 16: 799–809？？
[21]
21 Blake C, Delehanty B, Blake A, et al. Allosteric binding properties of a monoclonal antibody and its Fab fragment. Biochem, 2003, 42: 497–508？？
[22]
22 Chakrabarti P, Hatcher M, Blake A, et al. Enzyme immunoassay to determine heavy metals using antibodies to specific metal EDTA complexes: optimization and validation of an immunoassay for soluble indium. Anal Biochem, 1994, 217: 70–75？？
[23]
23 Delehanty B, Jones M, Blake A, et al. Identification of important residues in metal-chelate recognition by monoclonal anti-bodies. Biochem, 2003, 42: 14173–14183？？
[24]
24 Khosraviani M, Pavlov R, Blake A, et al. Detection of heavy metals by immunoassay: optimization and validation of a rapid, portable assay for ionic cadmium. Environ Sci Technol, 1998, 32: 137–142？？
[25]
25 Khosraviani M, Blake C, Blake A, et al. Binding properties of a monoclonal antibody directed toward lead chelate complexes. Bioconjugate Chem, 2000, 11: 267–277？？
[26]
26 Blake A, Pavlov R, Blake C, et al. Antibodies and antibody-based assays for hexavalent uranium. Anal Chim Acta, 2001, 444: 3–11？？
[27]
27 Maro P, Gee S, Hammock D, Immunochemical techniques for environmental analysis II. Antibody production and immunoassay development. Tren Anal Chem, 1995, 14: 415–418
[28]
28 Xie P, Xu W, Cao C X, et al. Mercuric mercaptide of penicillenic acid, a novel hapten for relevant immunoassay, synthesized from penicillin. J Immun Meth, 2010, 353: 1–7？？
[29]
29 Smith G, Grey E, Patel J, et al. The spectrophotometric determination of amipicillin. Analyst, 1967, 92: 247–252？？
[30]
30 Bundgaard K. A new spectrophotometric method for the determination of Penicillins. J Pharm, 1972, 24: 790–794？？
[31]
31 He H, Liu Y, Sun C, et al. Preparation of anti-cadium-EDTA complex polyclonal antibody and its application for dertermination of cadmium in aqueous solution. Anal Lett, 2009, 42: 409–442？？
[32]
32 de Weck A L, Eisen H N. Some immunochemical properties of penicillenic acid: an antigenic determinant derived from penicillin. J Exp Med, 1960, 112: 1227–1247？？
[33]
33 Carpenter H, Turner A, Vigeneaud V, et al. Benzylpenicillenic acid as an intermediate in the synthesis of benzylpenicillin (penicillin acid). J Biol Chem, 1948: 893–905
[34]
34 Singh V, Kaur J, Suri R, et al. Synthesis and characterization of papten-protein conjugates for antibody production against small molecules. Bioconjugate Chem, 2004, 15: 168–173？？
