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人呼吸道合胞病毒活疫苗研究进展

DOI: 10.1360/052010-513, PP. 1-12

Keywords: 人呼吸道合胞病毒,减毒活疫苗,病毒载体疫苗,反向遗传学,重组技术

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Abstract:

人呼吸道合胞病毒是引起婴幼儿支气管炎和肺炎的主要原因,也可导致免疫缺陷病人及老年人群显著发病和死亡.人呼吸道合胞病毒疫苗已被世界卫生组织(WorldHealthOrganization,WHO)列为全球最优先发展的疫苗之一.经过50多年的研究,尤其是随着重组技术和反向遗传学的出现,对RSV疫苗的研究取得了重要进展,但尚未有疫苗上市.目前主要集中于亚单位疫苗及活疫苗等,其中活疫苗包括减毒活疫苗和活病毒载体疫苗,因其最有可能用于预防婴幼儿RSV感染,而受到了较大关注.以rA2cp248/404/1030?SH为代表的RSV减毒活疫苗临床试验显示,其有较好的安全性及免疫保护作用,不产生疾病增强作用是极有潜力的候选疫苗.因此,本文将重点介绍RSV活疫苗研究的主要进展和发展方向.

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