75 Feng Y, Yu X. Cardinal roles of miRNA in cardiac development and disease. Sci China Life Sci, 2011, 54: 1113-1120？？
[2]
1 Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell, 2010, 140: 805-820？？
[3]
2 Netea M G, Wijmenga C, O’Neill L A. Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol, 2012, 13: 535-542？？
[4]
3 Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol, 2009, 21: 317-337？？
[5]
4 Loo Y M, Gale M Jr. Immune signaling by RIG-I-like receptors. Immunity, 2011, 34: 680-692？？
[6]
5 Maekawa T, Kufer T A, Schulze-Lefert P. NLR functions in plant and animal immune systems: so far and yet so close. Nat Immunol, 2011, 12: 817-826？？
[7]
6 Hancock R E, Nijnik A, Philpott D J. Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol, 2012, 10: 243-254？？
[8]
7 Qian C, Cao X. Regulation of Toll-like receptor signaling pathways in innate immune responses. Ann N Y Acad Sci, 2012, doi: 10.1111/j1749-6632.2012.06786.x
[9]
8 Han C, Jin J, Xu S, et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol, 2010, 11: 734-742？？
[10]
9 Rui Y, Liu X, Li N, et al. PECAM-1 ligation negatively regulates TLR4 signaling in macrophages. J Immunol, 2007, 179: 7344-7351
[11]
10 Xu S, Liu X, Bao Y, et al. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol, 2012, 13: 551-559？？
[12]
11 Liu X, Zhan Z, Li D, et al. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol, 2011, 12: 416-424？？
[13]
12 Wang C, Chen T, Zhang J, et al. The E3 ubiquitin ligase Nrdp1 ‘preferentially’ promotes TLR-mediated production of type I interferon. Nat Immunol, 2009, 10: 744-752？？
[14]
13 Yang M, Wang C, Zhu X, et al. E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. J Exp Med, 2011, 208: 2099-2112？？
[15]
14 An H, Hou J, Zhou J, et al. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol, 2008, 9: 542-550？？
[16]
15 An H, Zhao W, Hou J, et al. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity, 2006, 25: 919-928？？
[17]
16 An H, Xu H, Zhang M, et al. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. Blood, 2005, 105: 4685-4692？？
[18]
17 Xu H, An H, Hou J, et al. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol, 2008, 45: 3545-3552？？
[19]
18 Liu X, Yao M, Li N, et al. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood, 2008, 112: 4961-4970？？
[20]
19 Yao M, Liu X, Li D, et al. Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol, 2009, 183: 1751-1758？？
[21]
20 Wang Y, Chen T, Han C, et al. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood, 2007, 110: 962-971？？
[22]
21 Wu Y, Zhu X, Li N, et al. CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination. J Immunol, 2011, 187: 4881-4889？？
[23]
22 Yang P, An H, Liu X, et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin- dependent pathway. Nat Immunol, 2010, 11: 487-494
[24]
23 Chen T, Guo J, Han C, et al. Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway. J Immunol, 2009, 182: 1449-1459
[25]
24 Fang H, Wu Y, Huang X, et al. Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response. J Biol Chem, 2011, 286: 30393-30400？？
[26]
25 Jiang Y, Chen G, Zhang Y, et al. Nerve growth factor promotes TLR4 signaling-induced maturation of human dendritic cells in vitro through inducible p75NTR 1. J Immunol, 2007, 179: 6297-6304
[27]
26 Ramos H J, Gale M Jr. RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity. Curr Opin Virol, 2011, 1: 167-176？？
[28]
27 Bonardi V, Cherkis K, Nishimura M T, et al. A new eye on NLR proteins: focused on clarity or diffused by complexity? Curr Opin Immunol, 2012, 24: 41-50
[29]
28 Ebert M S, Sharp P A. Roles for microRNAs in conferring robustness to biological processes. Cell, 2012, 149: 515-524？？
[30]
29 Yang C, Wei W. The miRNA expression profile of the uveal melanoma. Sci China Life Sci, 2011, 54: 351-358？？
[31]
30 Mendell J T, Olson E N. MicroRNAs in stress signaling and human disease. Cell, 2012, 148: 1172-1187？？
[32]
31 Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol, 2010, 11: 373-384？？
[33]
32 O’Neill L A, Sheedy F J, McCoy C E. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol, 2011, 11: 163-175？？
[34]
33 Taganov K D, Boldin M P, Chang K J, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA, 2006, 103: 12481-12486？？
[35]
34 Ceppi M, Pereira P M, Dunand-Sauthier I, et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci USA, 2009, 106: 2735-2740？？
[36]
35 Tili E, Michaille J J, Cimino A, et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol, 2007, 179: 5082-5089
[37]
36 Starczynowski D T, Kuchenbauer F, Argiropoulos B, et al. Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype. Nat Med, 2010, 16: 49-58？？
[38]
37 Alsaleh G, Suffert G, Semaan N, et al. Bruton’s tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. J Immunol, 2009, 182: 5088-5097？？
[39]
38 Li T, Morgan M J, Choksi S, et al. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol, 2010, 11: 799-805？？
[40]
39 Chen R, Alvero A B, Silasi D A, et al. Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene, 2008, 27: 4712-4723？？
[41]
40 Feng W, Feng Y. MicroRNAs in neural cell development and brain diseases. Sci China Life Sci, 2011, 54: 1103-1112？？
42 Lehmann S M, Krüger C, Park B, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci, 2012, 15: 827-835？？
[44]
43 Chen K, Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet, 2007, 8: 93-103
[45]
44 Bazzoni F, Rossato M, Fabbri M, et al. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci USA, 2009, 106: 5282-5287？？
[46]
45 Qi J, Qiao Y, Wang P, et al. microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-kappaB1 in murine macrophages. FEBS Lett, 2012, 586: 1201-1207？？
[47]
46 Hu X, Chen J, Wang L, et al. Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol, 2007, 82: 237-243？？
[48]
47 Zhang M, Liu Q, Mi S, et al. Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol, 2011, 186: 4716-4724？？
[49]
48 Jennewein C, von Knethen A, Schmid T, et al. MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator- activated receptor gamma (PPARgamma) mRNA destabilization. J Biol Chem, 2010, 285: 11846-11853？？
[50]
49 Lagos D, Pollara G, Henderson S, et al. miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator. Nat Cell Biol, 2010, 12: 513-519？？
[51]
50 Worm J, Stenvang J, Petri A, et al. Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res, 2009, 37: 5784-5792？？
[52]
51 Sheedy F J, Palsson-McDermott E, Hennessy E J, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol, 2010, 11: 141-147？？
[53]
52 Iliopoulos D, Jaeger S A, Hirsch H A, et al. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell, 2010, 39: 493-506？？
[54]
53 Bai Y, Qian C, Qian L, et al. Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146a. J Immunol, 2012, 188: 5293-5302？？
[55]
54 O’Connell R M, Chaudhuri A A, Rao D S, et al. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci USA, 2009, 106: 7113-7118？？
[56]
55 Qian C, Jiang X, An H, et al. TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood, 2006, 108: 2307-2315？？
[57]
56 Qian C, An H, Yu Y, et al. TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Blood, 2007, 109: 3308-3315？？
[58]
57 Semaan N, Frenzel L, Alsaleh G, et al. miR-346 controls release of TNF-alpha protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization. PLoS One, 2011, 6: 1-11
[59]
58 El G M, McCall C E. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem, 2010, 285: 20940-20951？？
[60]
59 Lu T X, Munitz A, Rothenberg M E. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol, 2009, 182: 4994-5002？？
[61]
60 Ma F, Liu X, Li D, et al. MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol, 2010, 184: 6053-6059？？
[62]
61 Ma F, Xu S, Liu X, et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma. Nat Immunol, 2011, 12: 861-869
[63]
62 Hou J, Wang P, Lin L, et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol, 2009, 183: 2150-2158
[64]
63 Huang Z, Chen X, Yu B, et al. Cloning and functional characterization of rat stimulator of interferon genes (STING) regulated by miR-24. Dev Comp Immunol, 2012, 37: 414-420？？
[65]
64 MacMicking J D. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol, 2012, 12: 367-382？？
[66]
65 Li Y, Fan X, He X, et al. MicroRNA-466l inhibits antiviral innate immune response by targeting interferon-alpha. Cell Mol Immunol, 2012, doi: 10.1038/cmi.2012.35
[67]
66 Li S J, Chen Z, Zhu H H. Influence of miR-122 on IFN-alpha treatment for HCV infection. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2011, 40: 588-592
[68]
67 Papadopoulou A S, Dooley J, Linterman M A, et al. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor. Nat Immunol, 2012, 13: 181-187
[69]
68 Wang P, Gu Y, Zhang Q, et al. Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity. J Immunol, 2012, 189: 211-221？？
[70]
69 Umbach J L, Kramer M F, Jurak I, et al. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature, 2008, 454: 780-783
[71]
70 Liang D, Gao Y, Lin X, et al. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε. Cell Res, 2011, 21: 793-806？？
[72]
71 Franchi L, Munoz-Planillo R, Nunez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol, 2012, 13: 325-332？？
[73]
72 Haneklaus M, Gerlic M, Kurowska-Stolarska M, et al. Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1beta production. J Immunol, 2012, 189: 3795-3799？？
[74]
73 Bauernfeind F, Rieger A, Schildberg F A, et al. NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol, 2012, 189: 4175-4181？？
[75]
74 O’Connell R M, Rao D S, Baltimore D. microRNA regulation of inflammatory responses. Annu Rev Immunol, 2012, 30: 295-312？？
