1 Grosshans B, Ortiz D, Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA, 2006, 103:11821-11827？？
[2]
2 Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol, 2009, 10: 513-525
[3]
3 Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol, 2001, 2: 107-117？？
[4]
4 Fischer von Mollard G, Mignery G A, Baumert M, et al. Rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. Proc Natl Acad Sci USA, 1990, 87: 1988-1992？？
[5]
5 Mahoney T R, Liu Q, Itoh T, et al. Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mol Biol Cell,2006, 17: 2617-2625？？
[6]
6 Johnson J L, Brzezinska A A, Tolmachova T, et al. Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic, 2010, 11: 533-547？？
[7]
7 Gomi H, Mori K, Itohara S, et al. Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol Biol Cell, 2007, 18: 4377-4386？？
[8]
8 Thiagarajan R, Tewolde T, Li Y, et al. Rab3A negatively regulates activity-dependent modulation of exocytosis in bovine adrenal chromaffin cells. J Physiol, 2004, 555: 439-457
[9]
9 Chung S H, Joberty G, Gelino E A, et al. Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3. J Biol Chem, 1999, 274: 18113-18120
[10]
10 Schonn J S, van Weering J R, Mohrmann R, et al. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic, 2010, 11: 1415-1428？？
[11]
11 Gonzalez L Jr, Scheller R H. Regulation of membrane trafficking: structural insights from a Rab/effector complex. Cell, 1999, 96: 755-758？？
[12]
12 Fukuda M. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem, 2003, 278: 15373-15380
[13]
13 Staunton J, Ganetzky B, Nonet M L. Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. J Neurosci, 2001, 21: 9255-9264
[14]
14 Brenner S. The genetics of Caenorhabditis elegans. Genetics, 1974, 77: 71-94
[15]
15 Stiernagle T. Maintenance of C. elegans. WormBook, 2006, 2: 1-11
[16]
16 Christensen M, Estevez A, Yin X, et al. A primary culture system for functional analysis of C. elegans neurons and muscle cells. Neuron,2002, 33: 503-514？？
[17]
17 Strange K, Christensen M, Morrison R. Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies. Nat Protoc, 2007, 2: 1003-1012？？
[18]
18 Speese S, Petrie M, Schuske K, et al. UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans. J Neurosci, 2007, 27: 6150-6162？？
[19]
19 Bai L, Zhu D, Zhou K, et al. Differential properties of GTP- and Ca2+-stimulated exocytosis from large dense core vesicles. Traffic, 2006, 7:416-428？？
[20]
20 Olivo-Marin J C. Extraction of spots in biological images using multiscale products. Pattern Recogn, 2002, 35: 1989-1996？？
[21]
21 Jaqaman K, Loerke D, Mettlen M, et al. Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods, 2008, 5: 695-702？？
[22]
22 Weimer R M, Richmond J E, Davis W S, et al. Defects in synaptic vesicle docking in unc-18 mutants. Nat Neurosci, 2003, 6: 1023-1030？？
[23]
23 Hata Y, Slaughter C A, Sudhof T C. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature, 1993, 366:347-351？？
[24]
24 Oh E, Spurlin B A, Pessin J E, et al. Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance. Diabetes, 2005, 54: 638-647？？
[25]
25 Toonen R F, Kochubey O, de Wit H, et al. Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J, 2006, 25:3725-3737？？
[26]
26 Gordon D E, Bond L M, Sahlender D A, et al. A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells. Traffic, 2010, 11: 1191-1204？？
[27]
27 Zhou K M, Dong Y M, Ge Q, et al. PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons. Neuron, 2007, 56: 657-669？？
[28]
28 Ciufo L F, Barclay J W, Burgoyne R D, et al. Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Mol Biol Cell, 2005, 16: 470-482
[29]
29 Fukuda M. Rab27 and its effectors in secretory granule exocytosis: a novel docking machinery composed of a Rab27. effector complex. Biochem Soc Trans, 2006, 34: 691-695？？
[30]
30 Ostrowski M, Carmo N B, Krumeich S, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol,2010, 12: 19-30; sup: 11-13？？
[31]
31 Baldini G, Martelli A M, Tabellini G, et al. Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by {alpha}-actinin. J Biol Chem, 2005, 280: 34974-34984？？
[32]
32 Deng L, Kaeser P S, Xu W, et al. RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron,2011, 69: 317-331？？
[33]
33 Xu T, Rammner B, Margittai M, et al. Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis. Cell,1999, 99: 713-722？？
