1 Walsh R J, Kaldor I, Brading I, et al. The availability of iron in meat: some experiments with radioactive iron. Australas Ann Med, 1955, 4:272-276
[2]
2 Bjorn-Rasmussen E. Iron absorption from wheat bread. Influence of various amounts of bran. Nutr Metab, 1974, 16: 101-110？？
[3]
3 Carpenter C E, Mahoney A W. Contributions of heme and nonheme iron to human nutrition. Crit Rev Food Sci Nutr, 1992, 31: 333-367？？
[4]
4 Kauppinen R. Porphyrias. Lancet, 2005, 365: 241-252
[5]
5 Iolascon A, De Falco L, Beaumont C. Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica, 2009, 94: 395-408？？
[6]
6 West A R, Oates P S. Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol, 2008, 14:4101-4110？？
[7]
7 Grasbeck R, Kouvonen I, Lundberg M, et al. An intestinal receptor for heme. Scand J Haematol, 1979, 23: 5-9
[8]
8 Tenhunen R, Grasbeck R, Kouvonen I, et al. An intestinal receptor for heme: its parital characterization. Int J Biochem, 1980, 12: 713-716？？
[9]
9 Callender S T, Mallett B J, Smith M D. Absorption of haemoglobin iron. Br J Haematol, 1957, 3: 186-192？？
[10]
10 Heinrich H C, Gabbe E E, Kugler G. Comparative absorption of ferri-haemoglobin-59Fe-Ferro-haemoglobin-59Fe and 59Fe3+-59Fe2+ in humans with normal and depleted iron sotres. Eur J Clin Invest, 1971, 1: 321-327？？
[11]
11 Galbraith R A, Sassa S, Kappas A. Heme binding to murine erythroleukemia cells. Evidence for a heme receptor. J Biol Chem, 1985, 260:12198-12202
[12]
12 Grasbeck R, Majuri R, Kouvonen I, et al. Spectral and other studies on the intestinal haem receptor of the pig. Biochim Biophys Acta, 1982,700: 137-142？？
[13]
13 Worthington M T, Cohn S M, Miller S K, et al. Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. Am J Physiol Gastrointest Liver Physiol, 2001, 280: G1172-G1177
[14]
14 Vaghefi N, Guillochon D, Bureau F, et al. The effect of cysteine and 2,4-dinitrophenol on heme and nonheme absorption in a rat intestinal model. J Nutr Biochem, 2000, 11: 562-567
[15]
15 Wyllie J C, Kaufman N. An electron microscopic study of heme uptake by rat duodenum. Lab Invest, 1982, 47: 471-476
[16]
16 Shayeghi M, Latunde-Dada G O, Oakhill J S, et al. Identification of an intestinal heme transporter. Cell, 2005, 122: 789-801？？
[17]
17 Hentze M W, Muckenthaler M U, Andrews N C. Balancing acts: molecular control of mammalian iron metabolism. Cell, 2004, 117:285-297？？
[18]
18 Qiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell, 2006, 127: 917-928？？
[19]
19 Laftah A H, Latunde-Dada G O, Fakih S, et al. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). Br J Nutr, 2009, 101: 1150-1156？？
[20]
20 Nakai Y, Inoue K, Abe N, et al. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther, 2007, 322: 469-476？？
[21]
23 Severance S, Hamza I. Trafficking of heme and porphyrins in metazoa. Chem Rev, 2009, 109: 4596-4616？？
[22]
24 Tailor C S, Willett B J, Kabat D. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol, 1999, 73: 6500-6505
[23]
25 Quigley J G, Burns C C, Anderson M M, et al. Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood, 2000, 95: 1093-1099
[24]
26 Quigley J G, Yang Z, Worthington M T, et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell, 2004, 118:757-766？？
[25]
27 Knutson M D, Oukka M, Koss L M, et al. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA, 2005, 102: 1324-1328？？
[26]
28 Krishnamurthy P, Ross D D, Nakanishi T, et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem, 2004, 279: 24218-24225？？
[27]
29 Bailey-Dell K J, Hassel B, Doyle L A, et al. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim Biophys Acta, 2001, 1520: 234-241
[28]
30 Krishnamurthy P, Schuetz J D. The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival. Biometals, 2005, 18: 349-358？？
[29]
31 Jonker J W, Buitelaar M, Wagenaar E, et al. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci USA, 2002, 99: 15649-15654？？
[30]
32 Latunde-Dada G O, Simpson R J, McKie A T. Recent advances in mammalian haem transport. Trends Biochem Sci, 2006, 31: 182-188？？
[31]
33 Burkhard K A, Wilks A. Functional characterization of the Shigella dysenteriae heme ABC transporter. Biochemistry, 2008, 47: 7977-7979？？
[32]
34 Krishnamurthy P C, Du G, Fukuda Y, et al. Identification of a mammalian mitochondrial porphyrin transporter. Nature, 2006, 443: 586-589
[33]
35 Paterson J K, Shukla S, Black C M, et al. Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry, 2007, 46: 9443-9452？？
[34]
36 Robey R W, Steadman K, Polgar O, et al. Pheophorbide A is a specific probe for ABCG2 function and inhibition. Cancer Res, 2004, 64:1242-1246？？
[35]
37 Miyazaki E, Kida Y, Mihara K, et al. Switching the sorting mode of membrane proteins from cotranslational endoplasmic reticulum targeting to posttranslational mitochondrial import. Mol Biol Cell, 2005, 16: 1788-1799？？
[36]
38 Shirihai O S, Gregory T, Yu C, et al. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J, 2000, 19: 2492-2502？？
[37]
39 Graf S A, Haigh S E, Corson E D, et al. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem, 2004, 279: 42954-42963
41 Hamza I. Intracellular trafficking of porphyrins. ACS Chem Biol, 2006, 1: 627-629？？
[40]
42 Trakshel G M, Kutty R K, Maines M D. Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem, 1986, 261: 11131-11137
[41]
43 Delaby C, Pilard N, Hetet G, et al. A physiological model to study iron recycling in macrophages. Exp Cell Res, 2005, 310: 43-53？？
[42]
21 Oates P S, West A R. Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility. World J Gastroenterol, 2006, 12: 4281-4295
[43]
22 Rajagopal A, Rao A U, Amigo J, et al. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature,2008, 453: 1127-1131？？
