1 Reski R. Physcomitrella and Arabidopsis: the David and Goliath of reverse genetics. Trends Plant Sci, 1998, 3: 209–210？？
[2]
2 Schaefer D G. Gene targeting in Physcomitrella patens. Curr Opin Plant Biol, 2001, 4: 143–150？？
[3]
3 Anzu M, Manabu N, Keita A, et al. Abscisic acid-induced freezing tolerance in the moss Physcomitrella patens is accompanied by increased expression of stress-related genes. J Plant Physiol, 2003, 160: 475–483？？
[4]
4 ShintaroI, Nobuhiko O, Michiaki Y. Cold-inducible expression of the cell division cycle gene CDC48 and its promotion of cell proliferation during cold acclimation in zebrafish cells. FEBS Lett, 2003, 549: 14–20？？
[5]
5 Hirsch C, Gauss R, Horn S C, et al. The ubiquitylation machinery of the endoplasmic reticulum. Nature, 2009, 458: 453–460？？
[6]
6 Vembar S S, Brodsky J L. One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol, 2008, 9: 944–957？？
[7]
7 Ramadan K, Bruderer R, Spiga F M, et al. Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin. Nature, 2007, 450: 1258–1262？？
[8]
8 Halawani D, Latterich M. p97: The cell’s molecular purgatory? Mol Cell, 2006, 22: 713–717
[9]
9 Janiesch P C, Kim J, Mouysset J, et al. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol, 2007, 9: 379–390？？
[10]
10 Alexandru G, Graumann J, Smith G T, et al. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell, 2008,134: 804–816？？
[11]
11 De Bose-Boyd R A. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res, 2008, 18: 609–621？？
[12]
12 Ye Y. Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase. J Struct Biol, 2006, 156: 29–40？？
[13]
24 Pearce R S. Molecular analysis of acclimation to cold. Plant Growth Regul, 1999, 29: 47–76？？
[14]
25 Thomashow M F. Plant cold acclimation: freezing tolerance genes and regulatory mechanisms. Annu Rev Plant Physiol Plant Mol Biol,1999, 50: 571–599？？
[15]
26 Xin Z, Browse J. Cold comfort farm: the acclimation of plants to freezing temperatures. Plant Cell Environ, 2000, 23: 893–902？？
[16]
27 Seki M, Narusaka M, Abe H, et al. Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray. Plant Cell, 2001, 13: 61–72
[17]
28 Anzu M, Manabu N, Keiichi I, et al. Cold acclimation in bryophytes: low-temperature-induced freezing tolerance in Physcomitrella patens is associated with increases in expression levels of stress-related genes but not with increase in level of endogenous abscisic acid. Planta,2005, 220: 414–423？？
[18]
29 NDong C, Danyluk J, Wilson K E, et al. Cold-regulated cereal chloroplast late embryogenesis abundant-like proteins. Molecular characterization and functional analyses. Plant Physiol, 2002, 129: 1368–1381？？
[19]
30 Hara M, Terashima S, Fukaya T, et al. Enhancement of cold tolerance and inhibition of lipid peroxidation by citrus dihedron in transgenic tobacco. Planta, 2003, 217: 290–298
[20]
31 Fr？hlich K U, Fries H W, Rudiger M, et al. Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family ivolved in secretion, peroxisome formation, and gene expression. J Cell Biol, 1991, 114: 443–453？？
[21]
32 Petek B, Aysun P, Fadime A K. Different p97/VCP complexes function in retrotranslocation step of mammalian Er-associated degradation (ERAD). Int J Biochem Cell Biol, 2011, 43: 613–622？？
[22]
33 Moir D, Stewart S E, Osmond B C, et al. Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Cell, 1982, 100: 547–563
[23]
34 Shirogane T, Fukada T, Muller J M, et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity, 1999, 11: 709–719？？
[24]
35 Müller J M, Deinhardt K, Rosewell L, et al. Targeted deletion of p97 (VCP/CDC48) in mouse resultsin early embryonic lethality. BBRC,2007, 354: 459–465
[25]
36 Wu D, Chen P J, Chen S, et al. C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. Development, 1999, 126: 2021–2031
[26]
37 Ralf J B, Hans Z. Mechanisms of Cdc48/VCP-mediated cell death-from yeast apoptosis to human disease. Biochim Biophys Acta, 2008,1783: 1418–1435？？
[27]
38 Rati V, Robert O, Ruihua F, et al. Cdc48/p97 mediates UV-dependent turnover of RNA pol II. Molecular Cell, 2010, 41: 82–92
[28]
39 Yeung H O, Kloppsteck P, Niwa H, et al. Insights into adaptor binding to the AAA protein p97. Biochem Soc Trans, 2008, 36: 62–72？？
[29]
13 Sookhee P, David M R, Sebastian Y B. In planta analysis of the cell cycle-dependent localization of AtCDC48A and its critical roles in cell division, expansion, and differentiation. Plant Physiol, 2008, 148: 246–258？？
[30]
14 Rancour D M, Dickey C E, Park S, et al. Characterization of AtCDC48. Evidence for multiple membrane fusion mechanisms at the plane of cell division in plants. Plant Physiol, 2002, 130: 1241–1253？？
[31]
15 Feiler H S, Desprez T, Santoni V, et al. The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells. EMBO J, 1995, 14: 5626–5637
[32]
16 Zimmermann P, Hirsch-Hoffmann M, Hennig L, et al. GENEVESTIGATOR: Arabidopsis microarray database and analysis toolbox. Plant Physiol, 2004, 136: 2621–2632？？
[33]
17 Zimmermann P, Hennig L, Gruissem W. Gene-expression analysis and network discovery using Genevestigator. Trends Plant Sci, 2005, 10:407–409？？
[34]
18 Sookhee P, David M R, Sebastian Y B. In planta analysis of the cell cycle-dependent localization of AtCDC48A and its critical roles in cell division, expansion, and differentiation. Plant Physiol, 2008, 148: 246–258？？
[35]
19 Hansol B, Soo M C, Seong W Y, et al. Suppression of the ER-localized AAA ATPase NgCDC48 inhibits tobacco growth and development. Mol Cells, 2009, 28: 57–65？？
[36]
20 Ashton N W, Cove D J, Featherstone D R. The isolation and physiological analysis of mutants of the moss Physcomitrella patens. Planta,1979, 144: 437–442？？
[37]
21 Minami A, Nagao M, Arakawa K, et al. Abscisic acid-induced freezing tolerance in the moss Physcomitrella patens is accompanied by increased expression of stress-related genes. J Plant Physiol, 2003, 160: 475–483？？
[38]
22 Porra R J, Thompson W A, Kriedemann P E. Determination of accurate extinction coefficients and simultaneous equations for assaying chlorophylls a and b extracted with four different solvents: verification of the concentration of chlorophyll standards by atomic absorption spectroscopy. BBA-Bioenergetics, 1989, 975: 384–394？？
[39]
23 Nishiyama T, Fujita T, Shin I T, et al. Comparative genomics of Physcomitrella patens gametophy tictranscriptome and Arabidopsis thaliana: implication for land plant evolution. Proc Natl Acad Sci USA, 2003, 100: 8007–8012？？
