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茶多酚通过调节过氧化物酶体增殖物激活受体防治肥胖症

, PP. 533-540

Keywords: 肥胖,茶多酚,过氧化物酶体增殖物激活受体,高脂,代谢综合征

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Abstract:

本研究利用高脂饲料诱导的肥胖大鼠模型,研究了茶多酚通过调节过氧化物酶体增殖物激活受体防治肥胖症的机制.结果表明,茶多酚能够明显降低肥胖大鼠的体重、肝重及血清和肝脏甘油三酯的含量;同时,茶多酚在皮下和内脏白色脂肪组织中分别增高和降低过氧化物酶体增殖物激活受体γ的表达水平.另外,茶多酚可以上调皮下白色脂肪组织、内脏白色脂肪组织及褐色脂肪组织中过氧化物酶体增殖物激活受体δ的表达并增加褐色脂肪组织中脂肪β-氧化相关酶的表达.以上结果表明,茶多酚防治肥胖症的机制与其调节过氧化物酶体增殖物激活受体的相关通路有关.

References

[1]  1 National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults-the evidence report. Obes Res, 1998, 6 (Suppl 2): 51S-209S
[2]  2 Kopelman P G. Obesity as a medical problem. Nature, 2000, 404: 635-643
[3]  3 Dulloo A G, Seydoux J, Girardier L, et al. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord, 2000, 24: 252-258
[4]  4 Ashida H, Furuyashiki T, Nagayasu H, et al. Anti-obesity actions of green tea: possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis-related transcription factors. Biofactors, 2004, 22: 135-140
[5]  5 Furuyashiki T, Nagayasu H, Aoki Y, et al. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci Biotechnol Biochem, 2004, 68: 2353-2359
[6]  6 Tokimitsu I. Effects of tea catechins on lipid metabolism and body fat accumulation. Biofactors, 2004, 22: 141-143
[7]  7 Dufresne C J, Farnworth E R. A review of latest research findings on the health promotion properties of tea. J Nutr Biochem, 2001, 12: 404-421
[8]  24 DeFronzo R A. Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl, 2004, (143): 9-21
[9]  25 Spiegelman B M, Flier J S. Adipogenesis and obesity: rounding out the big picture. Cell, 1996, 87: 377-389
[10]  26 Tiraby C, Tavernier G, Lefort C, et al. Acquirement of brown fat cell features by human white adipocytes. J Biol Chem, 2003, 278: 33370- 33376
[11]  27 Abe K, Okada N, Tanabe H, et al. Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats. Biomed Res, 2009, 30: 25-29
[12]  28 Zhao B L, Li X J, He R G, et al. Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals. Cell Biophys, 1989, 14: 175-185
[13]  29 Guo Q, Zhao B, Li M, et al. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta, 1996, 1304: 210-222
[14]  30 Guo Q, Zhao B, Shen S, et al. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers. Biochim Biophys Acta, 1999, 1427: 13-23
[15]  31 Zhao B, Guo Q, Xin W. Free radical scavenging by green tea polyphenols. Methods Enzymol, 2001, 335: 217-231
[16]  32 Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest, 2004, 114: 1752-1761
[17]  33 Bondia-Pons I, Ryan L, Martinez J A. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem, 2012, 68: 701- 711
[18]  34 Keaney J F, Larson M G, Vasan R S, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol, 2003, 23: 434-439
[19]  35 Nakai M, Fukui Y, Asami S, et al. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J Agric Food Chem, 2005, 53: 4593-4598
[20]  8 Yang M, Wang C, Chen H. Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet. J Nutr Biochem, 2001, 12: 14-20
[21]  9 Klaus S, Pultz S, Thone-Reineke C, et al. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int J Obes (Lond), 2005, 29: 615-623
[22]  10 Nagao T, Komine Y, Soga S, et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr, 2005, 81: 122-129
[23]  11 Wang X, Song K S, Guo Q X, et al. The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase. Biochem Pharmacol, 2003, 66: 2039-2047
[24]  12 Mori M, Hasegawa N. Superoxide dismutase activity enhanced by green tea inhibits lipid accumulation in 3T3-L1 cells. Phytother Res, 2003, 17: 566-567
[25]  13 Choo J J. Green tea reduces body fat accretion caused by high-fat diet in rats through beta-adrenoceptor activation of thermogenesis in brown adipose tissue. J Nutr Biochem, 2003, 14: 671-676
[26]  14 Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature, 2000, 405: 421-424
[27]  15 Rosen E D, Spiegelman B M. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem, 2001, 276: 37731-37734
[28]  16 Wang Y X, Lee C H, Tiep S, et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell, 2003, 113: 159-170
[29]  17 Mukherjee R, Jow L, Croston G E, et al. Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. J Biol Chem, 1997, 272: 8071-8076
[30]  18 Walczak R, Tontonoz P. Setting fat on fire. Nat Med, 2003, 9: 1348-1349
[31]  19 Lee K. Transactivation of peroxisome proliferator-activated receptor alpha by green tea extracts. J Vet Sci, 2004, 5: 325-330
[32]  20 Shimabukuro M, Koyama K, Chen G, et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA, 1997, 94: 4637-4641
[33]  21 Pappachan J M, Chacko E C, Arunagirinathan G, et al. Management of hypertension and diabetes in obesity: non-pharmacological measures. Int J Hypertens, 2011, 2011: 398065
[34]  22 Kao Y H, Hiipakka R A, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology, 2000, 141: 980-987
[35]  23 Chen N, Bezzina R, Hinch E, et al. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res, 2009, 29: 784-793

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