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血管病变机制与血管功能调控研究的现状与趋势

DOI: 10.1360/052012-448, PP. 103-111

Keywords: 血管病变,血管功能调控,血管稳态,血管重构,研究热点

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Abstract:

本文从4个方面综述并讨论了血管病变机制与血管功能调控研究的重要意义、现状与发展趋势:(1)血管病变的机制研究是重大的社会需求,而且是国际医学领域关注的重要热点问题;(2)血管病变机制与血管功能调控研究的现状、前沿热点和关键科学问题;(3)血管稳态与重构的调控机制研究面临的困难与挑战;(4)中国在血管病变相关重大疾病研究领域的主要方向.通过对血管生物医学领域具有普遍性、前沿性的重要科学问题进行讨论,提出阐明血管稳态和重构的调控机制是研究血管病变机制的关键.研究中应注重多学科交叉,利用基因组学、生物信息学、再生医学、影像学、组织工程与材料工程等领域的新进展,建立各种新方法、新技术和新的模式生物,为研究以血管病变为病理基础的多种重大疾病的机制、及实现早期预警和防治奠定基础.

References

[1]  1 卫生部心血管中心. 中国心血管病报告2011. 北京: 中国大百科全书出版社, 2012. 1
[2]  2 Recio-Mayoral A, Mason J C, Kaski J C, et al. Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease. Eur Heart J, 2009, 30: 1837-1843
[3]  3 Gao J, Sun L, Huo L, et al. CYLD regulates angiogenesis by mediating vascular endothelial cell migration. Blood, 2010, 115: 4130-4137
[4]  4 Kim H S, Ullevig S L, Zamora D, et al. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci USA, 2012, 109: E2803-E2812
[5]  5 Ory D S, Schaffer J E. ApoA-1 in diabetes: damaged goods. Diabetes, 2010, 59: 2358-2359
[6]  6 Chiu J J, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev, 2011, 91: 327-387
[7]  7 Tabas I. The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ Res, 2010, 107: 839-850
[8]  8 Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell, 2010, 140: 771-776
[9]  9 Liang C P, Han S, Li G, et al. Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes, 2012, 61: 2609-2620
[10]  10 Kato J, Kitamura K, Eto T. Plasma adrenomedullin level and development of hypertension. J Hum Hypertens, 2006, 20: 566-570
[11]  11 Spyridon M, Moraes L A, Jones C I, et al. LXR as a novel antithrombotic target. Blood, 2011, 117: 5751-5761
[12]  12 Fu M, Zhang W, Wu L, et al. Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci USA, 2012, 109: 2943-2948
[13]  13 Nathan C, Ding A. Nonresolving inflammation. Cell, 2010, 140: 871-882
[14]  14 Rinkevich Y, Mori T, Sahoo D, et al. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol, 2012, 14: 1251-1260
[15]  15 Chang C P, Bruneau B G. Epigenetics and cardiovascular development. Annu Rev Physiol, 2012, 74: 41-68
[16]  16 Hergenreider E, Heydt S, Tréguer K, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol, 2012, 14: 249-256
[17]  17 Sun W J, Li Y S, Huang H D, et al. microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng, 2010, 12: 1-27
[18]  18 Batra N, Burra S, Siller-Jackson A J, et al. Mechanical stress-activated integrin alpha5beta1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci USA, 2012, 109: 3359-3364
[19]  19 Sanders K M, Koh S D, Ro S, et al. Regulation of gastrointestinal motility-insights from smooth muscle biology. Nat Rev Gastroenterol Hepatol, 2012, 9: 633-645
[20]  20 Hahn C, Schwartz M A. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol, 2009, 10: 53-62

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