20 Han J W, Zheng H F, Cui Y, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet, 2009, 41: 1234-1237??
[2]
21 Zhang F R, Huang W, Chen S M, et al. Genomewide association study of leprosy. N Engl J Med, 2009, 361: 2609-2618??
[3]
22 Bei J X, Li Y, Jia W H, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet, 2010, 42: 599-603??
[4]
23 Quan C, Ren Y Q, Xiang L H, et al. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. Nat Genet, 2010, 42: 614-618??
[5]
33 Shi Y, Hu Z, Wu C, et al. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet, 2011, 43: 1215-1218
[6]
34 Shi Y, Li Z, Xu Q, et al. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet, 2011, 43: 1224-1227
[7]
35 Yue W H, Wang H F, Sun L D, et al. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet, 2011, 43: 1228-123
[8]
36 Zhang F, Liu H, Chen S, et al. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet, 2011, 43: 1247-1251??
[9]
37 Huang X, Zhao Y, Wei X, et al. Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm. Nat Genet, 2011, 44: 32-39??
[10]
38 Wu C, Miao X, Huang L, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet, 2011, 44: 62-66??
[11]
39 Lin Z, Bei J X, Shen M, et al. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet, 2011, 44: 73-77??
[12]
40 Yu X Q, Li M, Zhang H, et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet, 2011, 44: 178-182??
[13]
41 Hu Z, Xia Y, Guo X, et al. A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet, 2011, 44: 183-186??
[14]
42 Lee Y C, Kuo H C, Chang J S, et al. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet, 2012, 44: 522-525 ??
[15]
43 Lu X, Wang L, Chen S, et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet, 2012, 44: 890-894??
[16]
44 Shi Y, Zhao H, Shi Y, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet, 2012, 44: 1020-1025??
[17]
45 Cheung C L, Lau K S, Ho A Y, et al. Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3. Nat Genet, 2012, 44: 1026-1029
[18]
46 Wu C, Kraft P, Zhai K, et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet, 2012, 44: 1090-1097??
[19]
47 Xu J, Mo Z, Ye D, et al. Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet, 2012, 44: 1231-1235
[20]
48 Jiang D K, Sun J, Cao G, et al. Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet, 2012, 45: 72-75??
[21]
49 Omenn G S, States D J, Adamski M, et al. Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. Proteomics, 2005, 5: 3226-3245
[22]
50 Deutsch E W, Eng J K, Zhang H, et al. Human plasma peptideAtlas. Proteomics, 2005, 5: 3497-3500??
[23]
51 Sun A, Jiang Y, Wang X, et al. Liverbase: a comprehensive view of human liver biology. J Proteome Res, 2010, 9: 50-58??
[24]
52 Wang Q, Zhang Y, Yang C, et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science, 2010, 328: 974
[25]
53 Zhong F, Yang D, Hao Y, et al. Regular patterns for proteome-wide distribution of protein abundance across species. PLoS One, 2012, 7: e32423??
[26]
54 Stelzl U, Worm U, Lalowski M, et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell, 2005, 122: 957-968??
[27]
55 Wang J, Huo K, Ma L, et al. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol, 2011, 7: 536
[28]
56 Pennisi E. Shining a light on the genome’s ‘dark matter’. Science, 2010, 330: 1614??
[29]
57 Wapinski O, Chang H Y. Long noncoding RNAs and human disease. Trends Cell Biol, 2011, 21: 354-361??
[30]
1 吴国盛. 科学的历程. 长沙: 湖南科学技术出版社, 1995
[31]
2 Gelbart W M. Databases in genomic research. Science, 1998, 282: 659-661??
[32]
3 Watson J D, Crick F H C. Genetical implications of the structure of deoxyribonucleic acid. Nature, 1953, 171: 964-967
[33]
4 Ryle A P, Sanger F, Smith L F, et al. The disulphide bonda of insulin. Biochem J, 1955, 60: 541-556
[34]
5 Kendrew J C, Bodo G, Dintzis H M, et al. A three-dimensional model of the myoglobin molecule obtained by x-ray analysis. Nature, 1958, 181: 662-666??
[35]
6 Crick F H C. On protein synthesis. Symp Soc Exp Biol XII, 1958, 12: 138-163
[36]
7 Jacob F, Perrin D, Sanchez C, et al. The operon: a group of genes with expression coordinated by an operator. C R Acad Sci Paris, 1960, 250: 1727-1729
[37]
8 Nirenberg M W, Matthaei J H. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc Natl Acad Sci USA, 1961, 47: 1588-1602??
[38]
9 Baltimore D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature, 1970, 226: 1209-1211??
[39]
10 Temin H M, Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature, 1970, 226: 1211-1213??
[40]
11 Linn S, Arber W. Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form. Proc Natl Acad Sci USA, 1968, 59: 1300-1306??
[41]
12 Smith H, Wilcox K W. A Restriction enzyme from Hemophilus influenzae *1I. Purification and general properties. J Mol Biol, 1970, 51: 379-391??
[42]
13 Stehelin D, Fujita D J, Padgett T, et al. Detection and enumeration of transformation-defective strains of avian sarcoma virus with molecular hybridization. Virology, 1977, 76: 675-684??
[43]
14 Sanger F, Air G M, Barrell B G, et al. Nucleotide sequence of bacteriophage phi X174 DNA. Nature, 1977, 265: 687-695??
[44]
15 Saiki R, Scharf S, Mullis K B, et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science, 1985, 230: 1350-1354??
[45]
16 Sanger F, Coulson A R. A rapid metho1985d for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol, 1975, 94: 441-448??
[46]
17 Gonzaga-Jauregui C, et al. Human genome sequencing in health and disease. Annu Rev Med, 2012, 63: 35-61??
[47]
18 Lander E S, et al. Initial sequencing and analysis of the human genome. Nature, 2001, 409: 860-921??
[48]
19 Zhang X J, Huang W, Yang S, et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet, 2009, 41: 205-210??
[49]
24 Zhang H, Zhai Y, Hu Z, et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet, 2010, 42: 755-758
[50]
25 Wang L D, Zhou F Y, Li X M, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet, 2010, 42: 759-763??
[51]
26 Huang X, Wei X, Sang T, et al. Genome-wide association studies of 14 agronomic traits in rice landraces. Nat Genet, 2010, 42: 961-967??
[52]
27 Chen Z J, Zhao H, He L, et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet, 2011, 43: 55-59
[53]
28 Wu C, Hu Z, He Z, et al. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet, 2011, 43: 345-349??
[54]
29 Wu C, Hu Z, He Z, et al. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet, 2011, 43: 679-684??
[55]
30 Sun L D, Xiao F L, Li Y, et al. Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat Genet, 2011, 43: 690-694??
[56]
31 Hu Z, Wu C, Shi Y, et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet, 2011, 43: 792-796
[57]
32 Chu X, Pan C M, Zhao S X, et al. A genome-wide association study identifies two new risk loci for Graves'' disease. Nat Genet, 2011, 43: 897-901??