4 Richert M M, Schwertfeger K L, Ryder J W, et al. An atlas of mouse mammary gland development. J Mammary Gland Biol Neoplasia, 2000, 5: 227-241
[5]
5 Clarkson R W, Wayland M T, Lee J, et al. Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res, 2004, 6: R92-R109
[6]
6 Master S R, Hartman J L, D''Cruz C M, et al. Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis. Mol Endocrinol, 2002, 16: 1185-1203
[7]
7 Rudolph M C, McManaman J L, Hunter L, et al. Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution. J Mammary Gland Biol Neoplasia, 2003, 8: 287-307
[8]
8 Malewski T, Kamiński S, Zwierzchowski L. Gene expression profiling of mouse mammary gland: transition from pregnancy to lactation. Anim Sci Pap Rep, 2005, 23: 159-169
[9]
9 Bionaz M, Loor J J. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics, 2008, 9: 366
[10]
10 Lemay D G, Neville M C, Rudolph M C, et al. Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Syst Biol, 2007, 1: 56
[11]
11 Rudolph M C, McManaman J L, Phang T, et al. Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol Genomics, 2006, 28: 323-336
[12]
12 Finucane K A, McFadden T B, Bond J P, et al. Onset of lactation in the bovine mammary gland: gene expression profiling indicates a strong inhibition of gene expression in cell proliferation. Funct Integr Genomics, 2008, 8: 251-264
[13]
13 Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet, 2009, 10: 57-63
[14]
14 Marguerat S, Bahler J. RNA-Seq: from technology to biology. Cell Mol Life Sci, 2010, 67: 569-579
[15]
15 Zhu J, He F, Hu S, et al. On the nature of human housekeeping genes. Trends Genet, 2008, 24: 481-484
[16]
16 Cui P, Lin Q, Ding F, et al. A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics, 2010, 96: 259-265
[17]
17 Kanamori M, Konno H, Osato N, et al. A genome-wide and nonredundant mouse transcription factor database. Biochem Biophys Res Commun, 2004, 322: 787-793
[18]
18 Greenbaum A L. Lysosomal enzyme changes in enforced mammary-gland involution. Biochem J, 1965, 97: 518-522
[19]
19 Helminen H J, Ericsson J L. Quantitation of lysosomal enzyme changes during enforced mammary gland involution. Exp Cell Res, 1970, 60: 419-426
[20]
20 Kreuzaler P A, Staniszewska A D, Li W, et al. Stat3 controls lysosomal-mediated cell death in vivo. Nat Cell Biol, 2011, 13: 303-309
[21]
21 Mortazavi A, Williams B A, McCue K, et al. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods, 2008, 5: 621-628
[22]
22 Dahlquist K D, Salomonis N, Vranizan K, et al. Genmapp, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genetics, 2002, 31: 19-20
[23]
23 Huang da W, Sherman B T, Lempicki R A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc, 2009, 4: 44-57
[24]
24 Cui P, Ding F, Lin Q, et al. Distinct contributions of replication and transcription to mutation rate variation of human genomes. Genomics Proteomics Bioinformatics, 2012, 10: 4-10
[25]
25 Ramskold D, Wang E T, Burge C B, et al. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput Biol, 2009, 5: e1000598
[26]
26 Lee E Y, Barcellos-Hoff M H, Chen L H, et al. Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells. In Vitro Cell Dev Biol, 1987, 23: 221-226
[27]
27 Rainard P, Poutrel B, Caffin J P. Lactoferrin and transferrin in bovine milk in relation to certain physiological and pathological factors. Ann Rech Vet, 1982, 13: 321-328
[28]
28 Bionaz M, Loor J J. Gene networks driving bovine mammary protein synthesis during the lactation cycle. Bioinform Biol Insights, 2011, 5: 83-98
[29]
29 DeSantiago S, Torres N, Tovar A R. Leucine catabolism in mammary tissue, liver and skeletal muscle of dam rat during lactation and weaning. Arch Med Res, 1998, 29: 25-32
[30]
64 Chida D, Wakao H, Yoshimura A, et al. Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules. Mol Endocrinol, 1998, 12: 1792-1806
[31]
65 Li S, Rosen J M. Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Mol Cell Biol, 1995, 15: 2063-2070
[32]
66 Lee C S, Oka T. A pregnancy-specific mammary nuclear factor involved in the repression of the mouse beta-casein gene transcription by progesterone. J Biol Chem, 1992, 267: 5797-5801
[33]
67 Watson C J, Gordon K E, Robertson M, et al. Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor. Nucleic Acids Res, 1991, 19: 6603-6610
[34]
68 Buser A C, Gass-Handel E K, Wyszomierski S L, et al. Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol, 2007, 21: 106-125
[35]
69 Oakes S R, Naylor M J, Asselin-Labat M L, et al. The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev, 2008, 22: 581-586
[36]
70 Thomas R S, Ng A N, Zhou J, et al. The Elf group of Ets-related transcription factors. ELF3 and ELF5. Adv Exp Med Biol, 2000, 480: 123-128
[37]
71 Zhou J, Chehab R, Tkalcevic J, et al. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J, 2005, 24: 635-644
[38]
72 Zhang J, Brewer S, Huang J, et al. Overexpression of transcription factor AP-2α suppresses mammary gland growth and morphogenesis. Dev Biol, 2003, 256: 127-145
[39]
73 Shen Q, Zhang Y, Uray I P, et al. The AP-1 transcription factor regulates postnatal mammary gland development. Dev Biol, 2006, 295: 589-603
[40]
74 Zhang J, Brewer S, Huang J, et al. Overexpression of transcription factor AP-2α suppresses mammary gland growth and morphogenesis. Dev Biol, 2003, 256: 127-145
[41]
75 Zhu Q, Anderson G W, Mucha G T, et al. The spot 14 protein is required for de novo lipid synthesis in the lactating mammary gland. Endocrinology, 2005, 146: 3343-3350
[42]
76 Kane R, Finlay D, Lamb T, et al. Transcription factor NF 1 expression in involuting mammary gland. Adv Exp Med Biol, 2000, 480: 117-122
[43]
77 Marti A, Lazar H, Ritter P, et al. Transcription factor activities and gene expression during mouse mammary gland involution. J Mammary Gland Biol Neoplasia, 1999, 4: 145-152
[44]
78 Sabatakos G, Davies G E, Grosse M, et al. Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution. Biochem J, 1998, 334: 205-210
[45]
79 Gigliotti A P, DeWille J W. Local signals induce CCAAT/enhancer binding protein-delta (C/EBP-delta) and C/EBP-beta mRNA expression in the involuting mouse mammary gland. Breast Cancer Res Treat, 1999, 58: 57-63
[46]
80 Gigliotti A P, DeWille J W. Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland. J Cell Physiol, 1998, 174: 232-239
[47]
81 Neve R, Chang C H, Scott G K, et al. The epithelium-specific Ets transcription factor ESX is associated with mammary gland development and involution. FASEB J, 1998, 12: 1541-1550
[48]
82 Chen J Q, Bao Y, Litton J, et al. Expression and relevance of TRPS-1: a new GATA transcription factor in breast cancer. Horm Cancer, 2011, 2: 132-143
[49]
83 Gai Z, Zhou G, Itoh S, et al. Trps1 functions downstream of Bmp7 in kidney development. J Am Soc Nephrol, 2009, 20: 2403-2411
[50]
84 Suemoto H, Muragaki Y, Nishioka K, et al. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Dev Biol, 2007, 312: 572-581
[51]
85 Ashworth T. Differential roles for TFⅡ-I in the cell cycle. Doctor Dissertation. Boston: Sackler School of Graduate Biomedical Sciences, Tufts University, 2009
[52]
86 Bagheri-Yarmand R, Vadlamudi R K, Kumar R. Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. J Biol Chem, 2003, 278: 17421-17429
[53]
87 Sambasivan R, Cheedipudi S, Pasupuleti N, et al. The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. J Cell Sci, 2009, 122: 3481-3491
[54]
88 Martin S, Driessen K, Nixon S J, et al. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem, 2005, 280: 42325-42335
90 Stein M P, Dong J, Wandinger-Ness A. Rab proteins and endocytic trafficking: potential targets for therapeutic intervention. Adv Drug Deliv Rev, 2003, 55: 1421-1437
[57]
91 Yoshizawa T, Handa Y, Uematsu Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet, 1997, 16: 391-396
[58]
92 Van Cromphaut S J, Dewerchin M, Hoenderop J G, et al. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA, 2001, 98: 13324-13329
[59]
93 Zinser G M, Welsh J. Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol, 2004, 18: 2208-2223
[60]
94 Bartkova J, Gr？n B, Dabelsteen E, et al. Cell-cycle regulatory proteins in human wound healing. Arch Oral Biol, 2003, 48: 125-132
[61]
95 Burgering B M, Kops G J. Cell cycle and death control: long live forkheads. Trends Biochem Sci, 2002, 27: 352-360
[62]
96 Bogachev O, Majdalawieh A, Pan X, et al. Adipocyte enhancer-binding protein 1 (AEBP1) (a novel macrophage proinflammatory mediator) overexpression promotes and ablation attenuates atherosclerosis in ApoE (-/-) and LDLR (-/-) mice. Mol Med, 2011, 17: 1056-1064
[63]
97 Liu H. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription. Doctor Dissertation. Umea: Umea University, 2005
[64]
98 Kugel J F, Goodrich J A. Non-coding RNAs: key regulators of mammalian transcription. Trends Biochem Sci, 2012, 37: 144-151
[65]
100 Piao H L, Ma L. Non-coding RNAs as regulators of mammary development and breast cancer. J Mammary Gland Biol Neoplasia, 2012, 17: 33-42
[66]
101 Johnson C D, Esquela-Kerscher A, Stefani G, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res, 2007, 67: 7713-7722
[67]
102 Iorio M V, Ferracin M, Liu C G, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res, 2005, 65: 7065-7070
[68]
103 Lee Y S, Kim H K, Chung S, et al. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation. J Biol Chem, 2005, 280: 16635-16641
[69]
104 Kosaka N, Izumi H, Sekine K, et al. MicroRNA as a new immune-regulatory agent in breast milk. Silence, 2010, 1: 7
[70]
105 Monticelli S, Ansel K M, Xiao C, et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol, 2005, 6: R71
[71]
106 Chassin C, Kocur M, Pott J, et al. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe, 2010, 8: 358-368
[72]
107 Lu L F, Boldin M P, Chaudhry A, et al. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell, 2010, 142: 914-929
[73]
99 Ginger M R, Shore A N, Contreras A, et al. A noncoding RNA is a potential marker of cell fate during mammary gland development. Proc Natl Acad Sci USA, 2006, 103: 5781-5786
[74]
30 Silveri L, Tilly G, Vilotte J L, et al. Microrna involvement in mammary gland development and breast cancer. Reprod Nutr Dev, 2006, 46: 549-556
[75]
31 Tsitsiou E, Lindsay M A. Micrornas and the immune response. Curr Opin Pharmacol, 2009, 9: 514-520
33 Pedersen I, David M. MicroRNAs in the immune response. Cytokine, 2008, 43: 391-394
[78]
34 Huber K, Muscher A, Breves G. Sodium-dependent phosphate transport across the apical membrane of alveolar epithelium in caprine mammary gland. Comp Biochem Physiol A Mol Integr Physiol, 2007, 146: 215-222
[79]
35 Traebert M, Hattenhauer O, Murer H, et al. Expression of type Ⅱ Na-Pi cotransporter in alveolar type Ⅱ cells. Am J Physiol, 1999, 277: L868-L873
[80]
36 Cerri M F, Rezende L C D, Paes M F, et al. The cotransporter NaPi-Ⅱb: characteristics, regulation and its role in carcinogenesis. Appl Cancer Res, 2010, 30: 197-203
[81]
37 Nordstr？m E A, Rydén M, Backlund E C, et al. A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes, 2005, 54: 1726-1734
[82]
38 Puri V, Ranjit S, Konda S, et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci USA, 2008, 105: 7833-7838
[83]
39 Nilsson J, Hellquist M, Bjursell G. The human carboxyl ester lipase-like (cell) gene is ubiquitously expressed and contains a hypervariable region. Genomics, 1993, 17: 416-422
[84]
40 Hui D Y, Howles P N. Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis. J Lipid Res, 2002, 43: 2017-2030
[85]
41 Nagaoka K, Aoki F, Hayashi M, et al. L-amino acid oxidase plays a crucial role in host defense in the mammary glands. FASEB J, 2009, 23: 2514-2520
[86]
42 Blakistone B A, Aurand L W, Swaisgood H E. Association of sulfhydryl oxidase and xanthine oxidase in bovine mammary tissue. J Dairy Sci, 1986, 69: 2803-2809
[87]
43 Clare D A, Blakistone B A, Swaisgood H E, et al. Sulfhydryl oxidase-catalyzed conversion of xanthine dehydrogenase to xanthine oxidase. Arch Biochem Biophys, 1981, 211: 44-47
[88]
44 Guillemin K, Groppe J, Ducker K, et al. The pruned gene encodes the drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development, 1996, 122: 1353-1362
46 Heckman-Stoddard B M, Vargo-Gogola T, Herrick M P, et al. P190A RhoGAP is required for mammary gland development. Dev Biol, 2011, 360: 1-10
[91]
47 Sinnamon M J, Carter K J, Sims L P, et al. A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis, 2008, 29: 880-886
[92]
48 VanHouten J, Sullivan C, Bazinet C, et al. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proc Natl Acad Sci USA, 2010, 107: 11405-11410
[93]
49 Reinhardt T A, Lippolis J D, Shull G E, et al. Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem, 2004, 279: 42369-42373
[94]
50 Pruitt K M, Reiter B. Biochemistry of peroxidase system: antimicrobial effects. In: Pruitt K M, Tenovuo J O, eds. The Lactoperoxidase System: Chemistry and Biological Significance. New York: Marcel Dekker Incorporated, 1985
[95]
51 Huntoon K M, Wang Y, Eppolito C A, et al. The acute phase protein haptoglobin regulates host immunity. J Leukoc Biol, 2008, 84: 170-181
[96]
52 McAdam K P, Elin R J, Sipe J D, et al. Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation. J Clin Invest, 1978, 61: 390-394
[97]
53 Molenaar A J, Harris D P, Rajan G H, et al. The acute-phase protein serum amyloid A3 is expressed in the bovine mammary gland and plays a role in host defence. Biomarkers, 2009, 14: 26-37
[98]
54 Liu C F, Parker K, Yao H H. Wnt4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One, 2010, 5: e10382
[99]
55 Ntlabati P C. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) through protein-protein interaction and its role in apoptosis. Master Dissertation. Johannesburg : University of the Witwatersrand, 2009
[100]
56 Baird M F, Graham S M, Baker J S, et al. Creatine-kinase-and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab, 2012, 2012: 960363
[101]
57 Baik M G, Lee M J, Choi Y J. Gene expression during involution of mammary gland (review). Int J Mol Med, 1998, 2: 39-44
[102]
58 Van Hekken D L, Eigel W N. Activity of lysosomal enzymes in murine mammary tissue through pregnancy, lactation, and involution. J Dairy Sci, 1986, 69: 1811-1816
[103]
59 Ollivier-Bouquet M. Effect of lysosomotropic agents on the stimulation of milk protein secretion by prolactin. Eur J Cell Biol, 1980, 22: 755-760
[104]
60 {Houdebine, 1980 #528}Hernandez-Montes H, Escudero I, Villalpando S. Changes in cathepsin D activity of maternal tissues during lactation and weaning in rats. Arch Med Res, 1999, 30: 10-13
[105]
61 Rowlands T M, Pechenkina I V, Hatsell S J, et al. Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci USA, 2003, 100: 11400-11405
[106]
62 Lei X, Zhang S, Bohrer A, et al. Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis. J Biol Chem, 2008, 283: 34819-34832
[107]
63 Liu X, Robinson G W, Wagner K U, et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev, 1997, 11: 179-186
[108]
108 Aranha M M, Santos D M, Xavier J M, et al. Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation. BMC Genomics, 2010, 11: 514
[109]
109 Chen Y Q, Wang X X, Yao X M, et al. MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency. Am J Nephrol, 2011, 34: 549-559
[110]
110 Cimmino A, Calin G A, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA, 2005, 102: 13944-13949
[111]
111 Wu C D, Kuo Y S, Wu H C, et al. MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. J Biomed Sci, 2011, 18: 80
