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载脂蛋白C1调控斑马鱼原肠胚形成中的外包运动

, PP. 29-38

Keywords: 外包运动,阿朴脂蛋白C1,E-钙粘蛋白,辐射状插入

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Abstract:

载脂蛋白C1(Apoc1)调控脂蛋白的代谢,但它在胚胎发育中的作用尚不清楚.本研究鉴定并揭示了斑马鱼Apoc1的一个转录本Apoc1b在原肠胚形成外包运动中的功能.Apoc1b主要在卵黄合胞层、胚胎腹部和侧部区域的内层细胞中表达,并形成从内层高表达到外层低表达的辐射状梯度.注射Apoc1b的反义吗啉导致斑马鱼胚胎深层细胞的外包运动阻滞.Apoc1b敲除或过表达胚胎中E-钙粘蛋白(E-cadherin)的辐射状插入和梯度分布均被干扰.因此,Apoc1b以依赖于浓度梯度的方式通过E-cadherin介导的辐射状插入调控外包运动.

References

[1]  26 Carreira-Barbosa F, Kajita M, Morel V, et al. Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development, 2009, 136: 383-392
[2]  27 Lin F, Chen S, Sepich D S, et al. Gα12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol, 2009, 184: 909-921
[3]  28 Schepis A, Sepich D, Nelson W J. αE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly. Development, 2012, 139: 537-546
[4]  29 Dominiczak M H, Caslake M J. Apolipoproteins: metabolic role and clinical biochemistry applications. Ann Clin Biochem, 2011, 48: 498-515
[5]  30 Bell R D, Winkler E A, Singh I, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature, 2012, 485: 512-516
[6]  31 Bu G. Apolipoprotein E and its receptors in Alzheimer''s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci, 2009, 10: 333-344
[7]  32 Hegele R A. Plasma lipoproteins: genetic influences and clinical implications. Nat Rev Genet, 2009, 10: 109-121
[8]  33 Lusis A J, Pajukanta P. A treasure trove for lipoprotein biology. Nat Genet, 2008, 40: 129-130
[9]  34 邹亮, 黄琼, 李骜, 等. 基于随机森林和富集分析的阿尔茨海默症GWA研究. 中国科学: 生命科学, 2012, 42: 639-647
[10]  35 van den Elzen P, Garg S, León L, et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature, 2005, 437: 906-910
[11]  36 Seetharam D, Mineo C, Gormley A K, et al. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res, 2006, 98: 63-72
[12]  37 Gafencu A V, Robciuc M R, Fuior E, et al. Inflammatory signaling pathways regulating ApoE gene expression in macrophages. J Biol Chem, 2007, 282: 21776-21785
[13]  38 Cho T, Jung Y, Koschinsky M L. Apolipoprotein(a), through its strong lysine-binding site in KIV10, mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway. J Biol Chem, 2008, 283: 30503-30512
[14]  39 Liu L, Craig A W, Meldrum H D, et al. Apolipoprotein(a) stimulates vascular endothelial cell growth and migration and signals through integrin αVβ3. Biochem J, 2009, 418: 325-336
[15]  40 Xia J H, Liu J X, Zhou L, et al. Apo-14 is required for digestive system organogenesis during fish embryogenesis and larval development. Int J Dev Biol, 2008, 52: 1089-1098
[16]  41 Zhou L, Wang Y, Yao B, et al. Molecular cloning and expression pattern of 14 kDa apolipoprotein in orange-spotted grouper, Epinephelus coioides. Comp Biochem Physiol B Biochem Mol Biol, 2005, 142: 432-437
[17]  42 Wang Y, Zhou L, Li Z, et al. Molecular cloning and expression characterization of ApoC-I in the orange-spotted grouper. Fish Physiol Biochem, 2008, 34: 339-348
[18]  43 Westerfield M. The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio). 4th ed. Eugene: University of Oregon Press, 2000
[19]  44 Kimmel C B, Ballard W W, Kimmel S R, et al. Stages of embryonic development of the zebrafish. Dev Dyn, 1995, 203: 253-310
[20]  45 Mei J, Li Z, Gui J. Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafish. PLoS ONE, 2009, 4: e4979
[21]  46 Liu J, Hu B, Wang Y, et al. Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. J Biol Chem, 2009, 284: 16679-16692
[22]  20 Lachnit M, Kur E, Driever W. Alterations of the cytoskeleton in all three embryonic lineages contribute to the epiboly defect of Pou5f1/Oct4 deficient MZspg zebrafish embryos. Dev Biol, 2008, 315: 1-17
[23]  21 Lunde K, Belting H, Driever W. Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade. Curr Biol, 2004, 14: 48-55
[24]  22 Giraldez A J, Cinalli R M, Glasner M E, et al. MicroRNAs regulate brain morphogenesis in zebrafish. Science, 2005, 308: 833-838
[25]  23 Cha Y I, Kim S H, Sepich D, et al. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev, 2006, 20: 77-86
[26]  24 Leskow F C, Holloway B A, Wang H, et al. The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci USA, 2006, 103: 5373-5378
[27]  25 Huang H, Lu F I, Jia S, et al. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development, 2007, 134: 979-988
[28]  47 Dolbeare F, Gratzner H, Pallavicini M G, et al. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA, 1983, 80: 5573-5577
[29]  48 Betchaku T, Trinkaus J P. Contact relations, surface activity, and cortical microfilaments of marginal cells of the enveloping layer and of the yolk syncytial and yolk cytoplasmic layers of fundulus before and during epiboly. J Exp Zool, 1978, 206: 381-426
[30]  49 Lepage S E, Bruce A E. Zebrafish epiboly: mechanics and mechanisms. Int J Dev Biol, 2010, 54: 1213-1228
[31]  50 Borghi N, Lowndes M, Maruthamuthu V, et al. Regulation of cell motile behavior by crosstalk between cadherin-and integrin-mediated adhesions. Proc Natl Acad Sci USA, 2010, 107: 13324-13329
[32]  1 Warga R M, Kimmel C B. Cell movements during epiboly and gastrulation in zebrafish. Development, 1990, 108: 569-580
[33]  2 Solnica-Krezel L. Conserved patterns of cell movements during vertebrate gastrulation. Curr Biol, 2005, 15: R213-R228
[34]  3 Niu X, Shi H, Peng J. The role of mesodermal signals during liver organogenesis in zebrafish. Sci China Life Sci, 2010, 53: 455-461
[35]  4 Arendt D, Nübler-Jung K. Rearranging gastrulation in the name of yolk: evolution of gastrulation in yolk-rich amniote eggs. Mech Dev, 1999, 81: 3-22
[36]  5 Solnica-Krezel L. Gastrulation in zebrafish—all just about adhesion? Curr Opin Genet Dev, 2006, 16: 433-441
[37]  6 Kane D A, Mcfarland K N, Warga R M. Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly. Development, 2005, 132: 1105-1116
[38]  7 Kane D, Adams R. Life at the edge: epiboly and involution in the zebrafish. Results Probl Cell Differ, 2002, 40: 117-135
[39]  8 Shimizu T, Yabe T, Muraoka O, et al. E-cadherin is required for gastrulation cell movements in zebrafish. Mech Dev, 2005, 122: 747-763
[40]  9 Solnica-Krezel L, Driever W. Microtubule arrays of the zebrafish yolk cell: organization and function during epiboly. Development, 1994, 120: 2443-2455
[41]  10 Wilkins S J, Yoong S, Verkade H, et al. Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Dev Biol, 2008, 314: 12-22
[42]  11 Hsu H J, Liang M R, Chen C T, et al. Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Nature, 2006, 439: 480-483
[43]  12 Cheng J C, Miller A L, Webb S E. Organization and function of microfilaments during late epiboly in zebrafish embryos. Dev Dyn, 2004, 231: 313-323
[44]  13 Siddiqui M, Sheikh H, Tran C, et al. The tight junction component Claudin E is required for zebrafish epiboly. Dev Dyn, 2010, 239: 715-722
[45]  14 K?ppen M, Fernández B G, Carvalho L, et al. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development, 2006, 133: 2671-2681
[46]  15 Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading in zebrafish gastrulation. Science, 2012, 338: 257-260
[47]  16 Sharma D, Holets L, Zhang X, et al. Role of Fyn kinase in signaling associated with epiboly during zebrafish development. Dev Biol, 2005, 285: 462-476
[48]  17 Tsai W B, Zhang X, Sharma D, et al. Role of Yes kinase during early zebrafish development. Dev Biol, 2005, 277: 129-141
[49]  18 Bruce A E, Howley C, Dixon F M, et al. T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish. Dev Dyn, 2005, 233: 105-114
[50]  19 Reim G, Mizoguchi T, Stainier D Y, et al. The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. Dev Cell, 2004, 6: 91-101

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