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Polycomb与心脏发育

DOI: 10.1360/N052015-00026, PP. 643-651

Keywords: 表观遗传学,心脏发育,Polycomb

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Abstract:

心脏作为维持血液循环的“泵”,在人体发挥重要作用.而心脏发育的正常进行则是维持其功能的基础.因此,对心脏发育及其调节的研究一直为科学家们所关注.Polycomb复合体是一组抑制基因转录的蛋白,参与调节多种组织器官发育相关基因的表达.越来越多的证据表明,Polycomb在心脏发育中起重要的调节作用.因此,进一步了解其调节作用的机制,将为解析先天性心脏病的发病机制提供有益线索.本文主要从表观遗传的角度,重点阐述了Polycomb蛋白复合体与心脏发育的关系.

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