23 Petrascheck M, Ye X L, Buck L B. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature, 2007, 450: 553-556
[2]
24 Broue F, Liere P, Kenyon C, et al. A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell, 2007, 6: 87-94
[3]
25 Ved R, Saha S, Westlund B, et al. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of Synuclein, Parkin and DJ-1 in Caenorhabditis elegans. J Biol Chem, 2005, 280: 42655-42668
[4]
26 Yen K, Mobbs C V. Dietary restriction and cold temperature both acutely reduce senescence in C. elegans. Open Longev Sci, 2007, 1: 8-13
[5]
27 Carrano A C, Liu Z, Dillin A, et al. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature, 2009, 460: 396-400
[6]
28 Chen D, Thomas E L, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet, 2009, 5: e1000486
[7]
29 Suda H, Sato K, Yanase S. Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans. Mech Ageing Dev, 2012, 133: 600-610
[8]
30 Schiavi A, Torgovnick A, Kell A, et al. Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Exp Gerontol, 2013, 48: 191-201
[9]
31 Fierro-Gonzalez J C, Gonzalez-Barrios M, Miranda-Vizuete A, et al. The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. Biochem Biophys Res Commun, 2011, 406: 478-482
[10]
32 Cabreiro F, Ackerman D, Doonan R, et al. Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med, 2011, 51: 1575-1582
[11]
33 Okuyama T, Inoue H, Ookuma S, et al. The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem, 2010, 285: 30274-30281
[12]
34 Iwasa H, Yu S, Xue J, et al. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-g, and IP3R activation. Aging Cell, 2010, 9: 490-505
[13]
37 Yang W, Hekimi S. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell, 2010, 9: 433-447
[14]
38 Morcos M, Du X L, Pfisterer F, et al. Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell, 2008, 7: 260-269
[15]
39 Ghazi A, Henis-Korenblit S, Kenyon C. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci USA, 2007, 104: 5947-5952
[16]
40 Oh S W, Mukhopadhyay A, Svrzikapa N, et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA, 2005, 102: 4494-4499
[17]
41 Kayser E B, Sedensky M M, Morgan P G, et al. The effects of complex I function and oxidative damage on lifespan and anesthetic sensity in Caenorhabditis elegans. Mach Ageing and Dev, 2004, 125: 455-464
[18]
42 Apfeld J, O''Connor G, Mcdonagh T, et al. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev, 2004, 18: 3004-3009
[19]
43 Libina N, Berman J R, Kenyon C, et al. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell, 2003, 115: 489-502
[20]
44 Melendez A, Talloczy Z, Seaman M, et al. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science, 2003, 301: 1387-1391
[21]
45 Hirose T, Nakano Y, Nagamatsu Y, et al. Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans. Development, 2003, 130: 1089-1099
[22]
46 Tissenbaum H A, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 2001, 410: 227-230
[23]
47 Melov S, Ravenscroft J, Malik S, et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science, 2000, 289: 1567-1569
[24]
48 De Haes W, Frooninckx L, Van Assche R, et al. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci USA, 2014, 111: e2501-e2509
[25]
35 Zhang Y, Shao Z Y, Zhai Z W, et al. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One, 2009, 4: e6348
[26]
36 Van Raamsdonk J M, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet, 2009, 5: e1000361
[27]
1 孙振球, 徐勇勇. 医学统计学. 北京: 人民卫生出版社, 2010. 299
[28]
2 Bishop N A, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature, 2007, 447: 545-549
[29]
3 Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One, 2010, 5: e8758
[30]
4 Cabreiro F, Au C, Leung K Y, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell, 2013, 153: 228-239
15 Kim J, Takahashi M, Shimizu T, et al. Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev, 2008, 129: 322-331
[42]
16 Evason K, Huang C, Yamben I, et al. Anticonvulsant medications extend worm life-span. Science, 2005, 307: 258-262
[43]
17 Adachi H, Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci, 2000, 55: B280-B285
[44]
18 Hunt P R, Son T G, Wilson M A, et al. Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. PLoS One, 2011, 6: e21922
[45]
19 Honda Y, Fujita Y, Maruyama H, et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One, 2011, 6: e23527
21 Wang X M, Wang X Y, Li L D, et al. Lifespan extension in Ceanorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem Biophys Res Commun, 2010, 400: 613-618