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抗衰老药物对线虫生存曲线影响的荟萃分析

DOI: 10.1360/N052014-00281, PP. 479-487

Keywords: 衰老,抗衰老,生存曲线,线虫,药物,荟萃分析

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Abstract:

随着世界人口老龄化步伐的加快,衰老机制及抗衰老药物的研究日益成为生物医学领域的热点前沿之一.国内外已有大量研究报道抗衰老药物能够延长多种模式生物包括线虫、果蝇、小鼠、大鼠及灵长类等的寿命,然而,这些药物延缓衰老方式的差异仍缺乏系统研究.因此,本研究以衰老研究的热点模式生物线虫为对象,搜集1990年以来国内外刊物上正式发表的有关抗衰老药物寿命试验的研究文献及其涉及的生存曲线,利用荟萃分析比较了不同抗衰老药物与生存曲线变化类型间的关系,并结合药物的药理作用探讨其延寿机制.生存曲线特征聚类结果与药物生物学分类交叉分析结果表明,药理作用类型与增益类型具有很强相关性,提示这2种分类方法的结果是匹配的.抗氧化剂类药物和控制血糖类药物对生存曲线的改善总体增益虽然不是最高,但相对于正常组生存曲线其增益部分呈平移形,表明该类药物可以通过改善年龄结构对整个群体产生显著增益,且其衰老曲线的特征与自然衰老相似.抗癫痫药物及胃肠道菌群相关药物总体增益较大,其曲线增益形状呈梯形,提示该类药物(尤其是胃肠道菌群相关药物)尽管显著延长了少数个体的最大寿命,但是从整个群体来看,大多数个体寿命延长程度并不明显,受益的少数个体可能需要较长的外界资源支持方能保持较长时间的存活状态,这种模式既不大众化也不经济.综上所述,清除自由基和控制血糖类药物对健康老年有着更为积极合理的作用与效应.

References

[1]  23 Petrascheck M, Ye X L, Buck L B. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature, 2007, 450: 553-556
[2]  24 Broue F, Liere P, Kenyon C, et al. A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell, 2007, 6: 87-94
[3]  25 Ved R, Saha S, Westlund B, et al. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of Synuclein, Parkin and DJ-1 in Caenorhabditis elegans. J Biol Chem, 2005, 280: 42655-42668
[4]  26 Yen K, Mobbs C V. Dietary restriction and cold temperature both acutely reduce senescence in C. elegans. Open Longev Sci, 2007, 1: 8-13
[5]  27 Carrano A C, Liu Z, Dillin A, et al. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature, 2009, 460: 396-400
[6]  28 Chen D, Thomas E L, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet, 2009, 5: e1000486
[7]  29 Suda H, Sato K, Yanase S. Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans. Mech Ageing Dev, 2012, 133: 600-610
[8]  30 Schiavi A, Torgovnick A, Kell A, et al. Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Exp Gerontol, 2013, 48: 191-201
[9]  31 Fierro-Gonzalez J C, Gonzalez-Barrios M, Miranda-Vizuete A, et al. The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. Biochem Biophys Res Commun, 2011, 406: 478-482
[10]  32 Cabreiro F, Ackerman D, Doonan R, et al. Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med, 2011, 51: 1575-1582
[11]  33 Okuyama T, Inoue H, Ookuma S, et al. The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem, 2010, 285: 30274-30281
[12]  34 Iwasa H, Yu S, Xue J, et al. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-g, and IP3R activation. Aging Cell, 2010, 9: 490-505
[13]  37 Yang W, Hekimi S. Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell, 2010, 9: 433-447
[14]  38 Morcos M, Du X L, Pfisterer F, et al. Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell, 2008, 7: 260-269
[15]  39 Ghazi A, Henis-Korenblit S, Kenyon C. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci USA, 2007, 104: 5947-5952
[16]  40 Oh S W, Mukhopadhyay A, Svrzikapa N, et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci USA, 2005, 102: 4494-4499
[17]  41 Kayser E B, Sedensky M M, Morgan P G, et al. The effects of complex I function and oxidative damage on lifespan and anesthetic sensity in Caenorhabditis elegans. Mach Ageing and Dev, 2004, 125: 455-464
[18]  42 Apfeld J, O''Connor G, Mcdonagh T, et al. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev, 2004, 18: 3004-3009
[19]  43 Libina N, Berman J R, Kenyon C, et al. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell, 2003, 115: 489-502
[20]  44 Melendez A, Talloczy Z, Seaman M, et al. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science, 2003, 301: 1387-1391
[21]  45 Hirose T, Nakano Y, Nagamatsu Y, et al. Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans. Development, 2003, 130: 1089-1099
[22]  46 Tissenbaum H A, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 2001, 410: 227-230
[23]  47 Melov S, Ravenscroft J, Malik S, et al. Extension of life-span with superoxide dismutase/catalase mimetics. Science, 2000, 289: 1567-1569
[24]  48 De Haes W, Frooninckx L, Van Assche R, et al. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci USA, 2014, 111: e2501-e2509
[25]  35 Zhang Y, Shao Z Y, Zhai Z W, et al. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One, 2009, 4: e6348
[26]  36 Van Raamsdonk J M, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet, 2009, 5: e1000361
[27]  1 孙振球, 徐勇勇. 医学统计学. 北京: 人民卫生出版社, 2010. 299
[28]  2 Bishop N A, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature, 2007, 447: 545-549
[29]  3 Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One, 2010, 5: e8758
[30]  4 Cabreiro F, Au C, Leung K Y, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell, 2013, 153: 228-239
[31]  5 杨文旭, 王昌禄, 崔桂友, 等. 香椿叶总黄酮对延缓秀丽线虫衰老影响的初步研究. 现代食品科技, 2010, 26: 931-933
[32]  6 Hedges L V, Olkin I. Statistical Methods for Meta-analysis. New York: Academic Press, 1985
[33]  7 Stuhlmacher A F, Gillespie T L. Managing conflict in the literature: meta-analysis as a research method. Int Negot, 2005, 10: 67-68
[34]  8 Rousseeuw P J. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math, 1987, 20: 53-65
[35]  9 张学工. 模式识别. 第3版. 北京: 清华大学出版社, 2010. 192-195
[36]  10 王丽萍, 金鑫, 黄磊, 等. DhHP-6延长秀丽线虫寿命的作用机制. 吉林大学学报(理学版), 2012, 50: 1045-1048
[37]  11 Ayyadevara S, Bharill P, Dandapat A, et al. Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal, 2013, 18: 481-490
[38]  12 王昌禄, 韩晓梅, 陈勉华, 等. Viili中胞外多糖的分离纯化及对秀丽线虫寿命的影响. 氨基酸和生物资源, 2011, 33: 64-67
[39]  13 韩洪杰, 王昌禄, 陈勉华, 等. 槲皮素对线虫抗衰老的影响及其机制的初步研究. 氨基酸和生物资源, 2011, 33: 35-38
[40]  14 Evason K, Collins J J, Huang C, et al. Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell, 2008, 7: 305-317
[41]  15 Kim J, Takahashi M, Shimizu T, et al. Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans. Mech Ageing Dev, 2008, 129: 322-331
[42]  16 Evason K, Huang C, Yamben I, et al. Anticonvulsant medications extend worm life-span. Science, 2005, 307: 258-262
[43]  17 Adachi H, Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci, 2000, 55: B280-B285
[44]  18 Hunt P R, Son T G, Wilson M A, et al. Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. PLoS One, 2011, 6: e21922
[45]  19 Honda Y, Fujita Y, Maruyama H, et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One, 2011, 6: e23527
[46]  20 汪晓燕, 王香明, 王丹巧, 等. 川芎提取物对线虫寿命的影响及分子机制研究. 中国中药杂志, 2010, 35: 1042-1045
[47]  21 Wang X M, Wang X Y, Li L D, et al. Lifespan extension in Ceanorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem Biophys Res Commun, 2010, 400: 613-618
[48]  22 蔡外娇, 张新民, 黄建华, 等. 淫羊藿总黄酮延缓秀丽隐杆线虫衰老的实验研究. 中国中西医结合杂志, 2008, 28: 522-525

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