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Cellular organization by self-organization : mechanisms and models for Min protein dynamics

DOI: 10.1083/jcb.200411122

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Abstract:

We use the oscillating Min proteins of Escherichia coli as a prototype system to illustrate the current state and potential of modeling protein dynamics in space and time. We demonstrate how a theoretical approach has led to striking new insights into the mechanisms of self-organization in bacterial cells and indicate how these ideas may be applicable to more complex structure formation in eukaryotic cells.

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