The hypothesis is that induced pluripotent stem cells (iPSC) derived Schwann cells and/or macrophages can be transplanted into acellular nerve graft in repairing injured nervous system. The efficiency of iPSC seeded acellular nerve graft may mimic the autologous peripheral nerve graft.
References
[1]
Schmidt, C.E. and Leach, J.B. (2003) Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng., 5, 293-347.
[2]
Gulati, A.K. and Cole, G.P. (1994) Immunogenicity and regenerative potential of acellular nerve allografts to repair peripheral nerve in rats and rabbits. Acta Neurochir (Wien), 126(2–4), 158-64.
[3]
Yu, J. and Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917-20.
[4]
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-72.
[5]
Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-76.