双链RNA(dsRNA)佐剂的比较——PIC、PICLC、PIC12U、PICKCa®
Comparison of dsRNA Adjuvants—PIC, PICLC, PIC12U and PICKCa®

DOI: 10.12677/OJNS.2015.34017, PP. 127-136

Keywords: 双链RNA，疫苗佐剂，皮卡
dsRNA, Vaccine Adjuvant, PICKCa

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Abstract:

双链RNA佐剂包括PIC、PICLC、PIC12U和皮卡(PICKCa？)，是多种膜式识别受体(TLR3、NOD、MAD-5和RID-1）的配体，熔点分别是PIC 57℃，PICKCa 80℃，PICLC 91℃。由于灵长目以上动物血清核酸酶对双链RNA的降解，前两种佐剂对猴和人体或者效果差或者副作用大，且美国FDA在2012年也把PIC12U否决了，而我们研制的皮卡佐剂(PICKCa？)弥补了其它dsRNA佐剂的不足，对灵长类动物和人安全有效。
dsRNA adjuvants include PIC, PICLC, PIC12U (Trade name Ampligen) and PICKCa？ (PIC-kanamycin- Cacl2). They are ligands of varied pattern recognition receptorsTLR3, NOD, MAD-5 and RID-1. The melt points are 57？C for PIC, 80？C for PICKCa, 91？C for PICLC respectively. Because of the degradation of double stranded RNA in the serum of primates and above, The first two kinds of adjuvants have poor effects or severe side effect to the monkey and human. PIC12U was also denied by US FDA in 2012, while PICKCa overcomes shortcomings of PIC, PICLC and PIC12U and it is safe and effective for monkey and human.

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