| [1] | Brose K, Bland KS, Wang KH, Arnott D, Henzel W, et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96: 795–806. pmid:10102268 doi: 10.1016/s0092-8674(00)80590-5
|
| [2] | Kidd T, Bland KS, Goodman CS (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785–794. pmid:10102267 doi: 10.1016/s0092-8674(00)80589-9
|
| [3] | Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, et al. (1998a) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92: 205–215. doi: 10.1016/s0092-8674(00)80915-0
|
| [4] | Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, et al. (1999) Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell 96: 771–784. pmid:10102266 doi: 10.1016/s0092-8674(00)80588-7
|
| [5] | Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, et al. (2008) Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. Am J Med Genet B Neuropsychiatr Genet 147B: 1019–1027. doi: 10.1002/ajmg.b.30697. pmid:18270976
|
| [6] | Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, et al. (2009) A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull 35: 96–108. doi: 10.1093/schbul/sbn155. pmid:19023125
|
| [7] | Chang BS, Katzir T, Liu T, Corriveau K, Barzillai M, et al. (2007) A structural basis for reading fluency: white matter defects in a genetic brain malformation. Neurology 69: 2146–2154. pmid:18056578 doi: 10.1212/01.wnl.0000286365.41070.54
|
| [8] | Seeger M, Tear G, Ferres-Marco D, Goodman CS (1993) Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10: 409–426. pmid:8461134 doi: 10.1016/0896-6273(93)90330-t
|
| [9] | Shu T, Richards LJ (2001) Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci 21: 2749–2758. pmid:11306627
|
| [10] | Ma L, Tessier-Lavigne M (2007) Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons. J Neurosci 27: 6843–6851. pmid:17581972 doi: 10.1523/jneurosci.1479-07.2007
|
| [11] | Johnson KG, Ghose A, Epstein E, Lincecum J, O'Connor MB, et al. (2004) Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance. Curr Biol 14: 499–504. pmid:15043815 doi: 10.1016/j.cub.2004.02.005
|
| [12] | Murray MJ, Whitington PM (1999) Effects of roundabout on growth cone dynamics, filopodial length, and growth cone morphology at the midline and throughout the neuropile. J Neurosci 19: 7901–7912. pmid:10479692
|
| [13] | Hutson LD, Chien CB (2002) Pathfinding and error correction by retinal axons: the role of astray/robo2. Neuron 33: 205–217. pmid:11804569 doi: 10.1016/s0896-6273(01)00579-7
|
| [14] | Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, et al. (2005) Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron 46: 205–217. pmid:15848800 doi: 10.1016/j.neuron.2005.03.019
|
| [15] | Hattori M, Osterfield M, Flanagan JG (2000) Regulated cleavage of a contact-mediated axon repellent. Science 289: 1360–1365. pmid:10958785 doi: 10.1126/science.289.5483.1360
|
| [16] | Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, et al. (2005) Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123: 291–304. pmid:16239146 doi: 10.1016/j.cell.2005.08.014
|
| [17] | Lin KT, Sloniowski S, Ethell DW, Ethell IM (2008) Ephrin-B2 induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem. doi: 10.1074/jbc.m804401200
|
| [18] | Marston DJ, Dickinson S, Nobes CD (2003) Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol 5: 879–888. pmid:12973357 doi: 10.1038/ncb1044
|
| [19] | Zimmer M, Palmer A, Kohler J, Klein R (2003) EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol 5: 869–878. pmid:12973358 doi: 10.1038/ncb1045
|
| [20] | Jurney WM, Gallo G, Letourneau PC, McLoon SC (2002) Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse. J Neurosci 22: 6019–6028. pmid:12122063 doi: 10.3410/f.1008171.102959
|
| [21] | Piper M, Anderson R, Dwivedy A, Weinl C, van Horck F, et al. (2006) Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron 49: 215–228. pmid:16423696 doi: 10.1016/j.neuron.2005.12.008
|
| [22] | Hines JH, Abu-Rub M, Henley JR (2010) Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsion by MAG. Nat Neurosci 13: 829–837. doi: 10.1038/nn.2554. pmid:20512137
|
| [23] | Onishi K, Shafer B, Lo C, Tissir F, Goffinet AM, et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci 33: 19071–19085. doi: 10.1523/JNEUROSCI.2800-13.2013. pmid:24305805
|
| [24] | Tojima T, Itofusa R, Kamiguchi H (2010) Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance. Neuron 66: 370–377. doi: 10.1016/j.neuron.2010.04.007. pmid:20471350
|
| [25] | Bartoe JL, McKenna WL, Quan TK, Stafford BK, Moore JA, et al. (2006) Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J Neurosci 26: 3192–3205. pmid:16554470 doi: 10.1523/jneurosci.3469-05.2006
|
| [26] | O'Donnell M, Chance RK, Bashaw GJ (2009) Axon growth and guidance: receptor regulation and signal transduction. Annu Rev Neurosci 32: 383–412. doi: 10.1146/annurev.neuro.051508.135614. pmid:19400716
|
| [27] | Williams ME, Wu SC, McKenna WL, Hinck L (2003) Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism. J Neurosci 23: 11279–11288. pmid:14672991 doi: 10.3410/f.1017612.204325
|
| [28] | Keleman K, Rajagopalan S, Cleppien D, Teis D, Paiha K, et al. (2002) Comm sorts robo to control axon guidance at the Drosophila midline. Cell 110: 415–427. pmid:12202032 doi: 10.1016/s0092-8674(02)00901-7
|
| [29] | Keleman K, Ribeiro C, Dickson BJ (2005) Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo. Nat Neurosci 8: 156–163. pmid:15657595 doi: 10.1038/nn1388
|
| [30] | Yoo S, Kim Y, Noh H, Lee H, Park E, et al. (2011) Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map. EMBO J 30: 1593–1607. doi: 10.1038/emboj.2011.44. pmid:21343910
|
| [31] | Coleman HA, Labrador JP, Chance RK, Bashaw GJ (2010) The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. Development 137: 2417–2426. doi: 10.1242/dev.047993. pmid:20570941
|
| [32] | Fan X, Labrador JP, Hing H, Bashaw GJ (2003) Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron 40: 113–127. pmid:14527437 doi: 10.1016/s0896-6273(03)00591-9
|
| [33] | Hsouna A, Kim YS, VanBerkum MF (2003) Abelson tyrosine kinase is required to transduce midline repulsive cues. J Neurobiol 57: 15–30. pmid:12973825 doi: 10.1002/neu.10232
|
| [34] | Hu H, Li M, Labrador JP, McEwen J, Lai EC, et al. (2005) Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc Natl Acad Sci U S A 102: 4613–4618. pmid:15755809 doi: 10.1073/pnas.0409325102
|
| [35] | Gonzalez-Gaitan M, Jackle H (1997) Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell 88: 767–776. pmid:9118220 doi: 10.1016/s0092-8674(00)81923-6
|
| [36] | Guichet A, Wucherpfennig T, Dudu V, Etter S, Wilsch-Brauniger M, et al. (2002) Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. EMBO J 21: 1661–1672. pmid:11927550 doi: 10.1093/emboj/21.7.1661
|
| [37] | Moline MM, Southern C, Bejsovec A (1999) Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. Development 126: 4375–4384. pmid:10477304
|
| [38] | van der Bliek AM, Redelmeier TE, Damke H, Tisdale EJ, Meyerowitz EM, et al. (1993) Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol 122: 553–563. pmid:8101525 doi: 10.1083/jcb.122.3.553
|
| [39] | O'Donnell MP, Bashaw GJ (2013) Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation. J Neurosci 33: 305–314. doi: 10.1523/JNEUROSCI.2756-12.2013. pmid:23283343
|
| [40] | Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, et al. (1995) Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269: 1872–1875. pmid:7569928 doi: 10.1126/science.7569928
|
| [41] | Sorkin A, Mazzotti M, Sorkina T, Scotto L, Beguinot L (1996) Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif. J Biol Chem 271: 13377–13384. pmid:8662849 doi: 10.1074/jbc.271.23.13377
|
| [42] | Wisco D, Anderson ED, Chang MC, Norden C, Boiko T, et al. (2003) Uncovering multiple axonal targeting pathways in hippocampal neurons. J Cell Biol 162: 1317–1328. pmid:14517209 doi: 10.1083/jcb.200307069
|
| [43] | Fukuhara N, Howitt JA, Hussain SA, Hohenester E (2008) Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. J Biol Chem 283: 16226–16234. doi: 10.1074/jbc.M800688200. pmid:18359766
|
| [44] | Howitt JA, Clout NJ, Hohenester E (2004) Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit. Embo J 23: 4406–4412. pmid:15496984 doi: 10.1038/sj.emboj.7600446
|
| [45] | Liu Z, Patel K, Schmidt H, Andrews W, Pini A, et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol Cell Neurosci 26: 232–240. pmid:15207848 doi: 10.1016/j.mcn.2004.01.002
|
| [46] | Bashaw GJ, Goodman CS (1999) Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion. Cell 97: 917–926. pmid:10399919 doi: 10.1016/s0092-8674(00)80803-x
|
| [47] | Bashaw GJ, Kidd T, Murray D, Pawson T, Goodman CS (2000) Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703–715. pmid:10892742 doi: 10.1016/s0092-8674(00)80883-1
|
| [48] | Yang L, Bashaw GJ (2006) Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Neuron 52: 595–607. pmid:17114045 doi: 10.1016/j.neuron.2006.09.039
|
| [49] | Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, et al. (2006) Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 10: 839–850. pmid:16740485 doi: 10.1016/j.devcel.2006.04.002
|
| [50] | Slovakova J, Speicher S, Sanchez-Soriano N, Prokop A, Carmena A (2012) The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline. J Neurosci 32: 10035–10044. doi: 10.1523/JNEUROSCI.6342-11.2012. pmid:22815517
|
| [51] | Seto ES, Bellen HJ (2006) Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol 173: 95–106. pmid:16606693 doi: 10.1083/jcb.200510123
|
| [52] | Vaccari T, Lu H, Kanwar R, Fortini ME, Bilder D (2008) Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol 180: 755–762. doi: 10.1083/jcb.200708127. pmid:18299346
|
| [53] | Jekely G, Sung HH, Luque CM, Rorth P (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell 9: 197–207. pmid:16054027 doi: 10.1016/j.devcel.2005.06.004
|
| [54] | Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, et al. (2010) VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 18: 713–724. doi: 10.1016/j.devcel.2010.02.016. pmid:20434959
|
| [55] | Palamidessi A, Frittoli E, Garré M, Faretta M, Mione M, et al. (2008) Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell 134: 135–147. doi: 10.1016/j.cell.2008.05.034. pmid:18614017
|
| [56] | Slessareva JE, Routt SM, Temple B, Bankaitis VA, Dohlman HG (2006) Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 126: 191–203. pmid:16839886 doi: 10.1016/j.cell.2006.04.045
|
| [57] | Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, et al. (2006) p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol 175: 861–868. pmid:17178906 doi: 10.1083/jcb.200607025
|
| [58] | Sorkin A, von Zastrow M (2009) Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 10: 609–622. doi: 10.1038/nrm2748. pmid:19696798
|
| [59] | Gupta GD, Swetha MG, Kumari S, Lakshminarayan R, Dey G, et al. (2009) Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. PLoS One 4: e6768. doi: 10.1371/journal.pone.0006768. pmid:19707569
|
| [60] | Piper M, Salih S, Weinl C, Holt CE, Harris WA (2005) Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation. Nat Neurosci 8: 179–186. pmid:15643427 doi: 10.1038/nn1380
|
| [61] | Galperin E, Sorkin A (2003) Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis. J Cell Sci 116: 4799–4810. pmid:14600265 doi: 10.1242/jcs.00801
|
| [62] | Das B, Shu X, Day GJ, Han J, Krishna UM, et al. (2000) Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem 275: 15074–15081. pmid:10748082 doi: 10.1074/jbc.m907269199
|
| [63] | Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, et al. (1999) Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol 1: 249–252. pmid:10559924 doi: 10.1038/12075
|
| [64] | Li G, D'Souza-Schorey C, Barbieri MA, Roberts RL, Klippel A, et al. (1995) Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A 92: 10207–10211. pmid:7479754 doi: 10.1073/pnas.92.22.10207
|
| [65] | Ozdinler PH, Erzurumlu RS (2002) Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS. J Neurosci 22: 4540–4549. pmid:12040061
|
| [66] | Whitford KL, Marillat V, Stein E, Goodman CS, Tessier-Lavigne M, et al. (2002) Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 33: 47–61. pmid:11779479 doi: 10.1016/s0896-6273(01)00566-9
|
| [67] | Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, et al. (1999) Mena is required for neurulation and commissure formation. Neuron 22: 313–325. pmid:10069337 doi: 10.1016/s0896-6273(00)81092-2
|
| [68] | Matusek T, Gombos R, Szecsenyi A, Sanchez-Soriano N, Czibula A, et al. (2008) Formin proteins of the DAAM subfamily play a role during axon growth. J Neurosci 28: 13310–13319. doi: 10.1523/JNEUROSCI.2727-08.2008. pmid:19052223
|
| [69] | Kapfhammer JP, Raper JA (1987) Collapse of growth cone structure on contact with specific neurites in culture. J Neurosci 7: 201–212. pmid:3543248
|
| [70] | Falk J, Konopacki FA, Zivraj KH, Holt CE (2014) Rab5 and Rab4 regulate axon elongation in the Xenopus visual system. J Neurosci 34: 373–391. doi: 10.1523/JNEUROSCI.0876-13.2014. pmid:24403139
|
| [71] | van Bergeijk P, Adrian M, Hoogenraad CC, Kapitein LC (2015) Optogenetic control of organelle transport and positioning. Nature 518: 111–114. doi: 10.1038/nature14128. pmid:25561173
|
| [72] | Itofusa R, Kamiguchi H (2011) Polarizing membrane dynamics and adhesion for growth cone navigation. Mol Cell Neurosci 48: 332–338. doi: 10.1016/j.mcn.2011.03.007. pmid:21459144
|
| [73] | Diefenbach TJ, Guthrie PB, Stier H, Billups B, Kater SB (1999) Membrane recycling in the neuronal growth cone revealed by FM1-43 labeling. J Neurosci 19: 9436–9444. pmid:10531447
|
| [74] | Kamiguchi H, Lemmon V (2000) Recycling of the cell adhesion molecule L1 in axonal growth cones. J Neurosci 20: 3676–3686. pmid:10804209
|
| [75] | Campbell DS, Holt CE (2001) Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32: 1013–1026. pmid:11754834 doi: 10.1016/s0896-6273(01)00551-7
|
