Normal kidney aging is related to tissue and functional changes that make older patients very vulnerable to environmental modifications. Numerous factors can accelerate the impairment of renal function during aging. It was a single-center retrospective study extending over a period of 30 years from 1984 to 2014 and includes patients older than 65 years, hospitalized for nephropathy requiring renal biopsy and monitored in our service. There were 6 men and 7 women with an average age of 69.38 ± 4.5 years. Mean serum creatinine was 267.15 ± 124 mmol/l. Eleven patients had renal failure. Histological lesions were: Extramembranous glomerulonephritis (EMGN): 1 case, focal segmental glomerular sclerosis (FSGS): 3 cases, membranoproliferative glomerulonephritis (MPGN): 1 case, IgA nephropathy: 1 case, glomerulonephritis with IgG4 fibrillar deposits (GN IgG4): 1 case, diabetic nephropathy: 2 cases, myeloma-associated tubulopathy: 1 case, acute tubular necrosis: 1 case, acute interstitial nephritis: 1 case, vascular nephropathy: 1 case. Kidney disease will increasingly become a geriatric illness. Nephrologists are encountering a growing group of elderly patients with diminished equation for estimated glomerular filtration rate (eGFR) that require evaluation and management.
References
[1]
Bolignano, D., Mattace-Raso, F., Sijbrands, E.J. and Zoccali, C. (2014) The Aging Kidney Revisited: A Systematic Review. Ageing Research Reviews, 14, 65-80. http://dx.doi.org/10.1016/j.arr.2014.02.003
[2]
James, M.T., Hemmelgarn, B.R. and Tonelli, M. (2010) Early Recognition and Prevention of Chronic Kidney Disease. The Lancet, 375, 1296-1309. http://dx.doi.org/10.1016/S0140-6736(09)62004-3
[3]
Heras, M., Fernández-Reyes, M.J., Guerrero, M.T., Sánchez, R., Munoz, A., Macías, M.C., et al. (2009) Elderly Patients with Chronic Kidney Disease: What Happens after 24 Months of Follow-Up? Nefrologia, 29, 343-349.
[4]
Campbell, K.H. and O’Hare, A.M. (2008) Kidney Disease in the Elderly: Update on Recent Literature. Current Opinion in Nephrology & Hypertension, 17, 298-303. http://dx.doi.org/10.1097/MNH.0b013e3282f5dd90
[5]
Roderick, P.J., Atkins, R.J., Smeeth, L., Mylne, A., Nitsch, D.D., Hubbard, R.B., et al. (2009) CKD and Mortality Risk in Older People: A Community-Based Population Study in the United Kingdom. American Journal of Kidney Diseases, 53, 950-960. http://dx.doi.org/10.1053/j.ajkd.2008.12.036
[6]
Anderson, S., Halter, J.B., Hazzard, W.R., Himmelfarb, J., Horne, F.M., Kaysen, G.A., et al. (2009) Prediction, Progression and Outcomes of Chronic Kidney Disease. Journal of the American Society of Nephrology, 20, 1199-1209. http://dx.doi.org/10.1681/ASN.2008080860
[7]
Moutzouris, D.A., Herlitz, L., Appel, G.B., Markowitz, G.S., Freudenthal, B., Radhakrishnan, J., et al. (2008) Renal Biopsy in the Very Elderly. Clinical Journal of the American Society of Nephrology, 4, 1073-1082. http://dx.doi.org/10.2215/CJN.00990209
[8]
García de Vinuesa, S. (2008) Progression Factors for Chronic Kidney Disease. Secondary Prevention. Nefrologia, S3, 17-21.
[9]
Rodriguez-Puyol, D. (1998) Nephrology Forum. The Aging Kidney. Kidney International, 54, 2247-2265. http://dx.doi.org/10.1038/4499994
[10]
Celik, B., Yaz, M., Bulut, T., Sahin, S., Alp, A. and Meteoglu, I. (2013) Is Focal Segmental Glomerulosclerosis Common among the Elderly? Geriatric Biopsy Results. Saudi Medical Journal, 34, 760-763.
[11]
Rosner, M., Abdel-Rahman, E. and Williams, M.E. (2010) Geriatric Nephrology: Responding to a Growing Challenge. Clinical Journal of the American Society of Nephrology, 5, 936-942. http://dx.doi.org/10.2215/CJN.08731209
[12]
Brown, E.A., Johansson, L., Farrington, K., Gallagher, H., Sensky, T., Gordon, F., et al. (2010) Broadening Options for Long-Term Dialysis in the Elderly (BOLDE): Differences in Quality of Life on Peritoneal Dialysis Compared to Haemodialysis for Older. Nephrology Dialysis Transplantation, 25, 3755-3763. http://dx.doi.org/10.1093/ndt/gfq212
[13]
Foote, C., Ninomiya, T., Gallagher, M., Perkovic, V., Cass, A., McDonald, S.P., et al. (2012) Survival of Elderly Dialysis Patients Is Predicted by Both Patient and Practice Characteristics. Nephrology Dialysis Transplantation, 27, 3581-3587. http://dx.doi.org/10.1093/ndt/gfs096
[14]
Telford, K., Kralik, D. and Koch, T. (2006) Acceptance and Denial: Implications for People Adapting to Chronic Illness: Literature Review. Journal of Advanced Nursing, 55, 457-464. http://dx.doi.org/10.1111/j.1365-2648.2006.03942.x
[15]
Jadoulle, V., Hoyois, P. and Jadoul, M. (2005) Anxiety and Depression in Chronic Hemodialysis: Some Somatopsychic Determinants. Clinical Nephrology, 63, 113-118. http://dx.doi.org/10.5414/CNP63113
[16]
Laudański, K., Nowak, Z. and Niemczyk, S. (2013) Age-Related Differences in the Quality of Life in End-Stage Renal Disease in Patients Enrolled in Hemodialysis or Continuous Peritoneal Dialysis. Medical Science Monitor, 19, 378-385. http://dx.doi.org/10.12659/MSM.883916
[17]
Schell, J.O., Patel, U.D., Steinhauser, K.E., Ammarell, N. and Tulsky, J.A. (2012) Discussions of the Kidney Disease Trajectory by Elderly Patients and Nephrologists: A Qualitative Study. American Journal of Kidney Diseases, 59, 495-503. http://dx.doi.org/10.1053/j.ajkd.2011.11.023
