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普朗尼克F127调控下MnFe2O4纳米粒子的共沉淀制备及其性能表征
Pluronic F127 Regulated Coprecipitation Preparation and Characterization of MnFe2O4 Nanoparticles

DOI: 10.12677/MS.2015.53017, PP. 119-125

Keywords: MnFe2O4纳米粒子，普朗尼克F127，共沉淀法，铁磁性，细胞相容性
MnFe2O4 Nanoparticles, Pluronic F127, Coprecipitation, Ferromagnetism, Cytocompatibility

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Abstract:

MnFe2O4纳米粒子在核磁共振成像和肿瘤磁热疗的应用上具有很大潜力。但是其应用于生物医学领域的主要障碍是难以制备形貌均一、分散性好、磁性能优异且生物相容性良好的MnFe2O4纳米粒子。目的：通过F127调控下的共沉淀法制备粒径均匀且磁性能较好的MnFe2O4纳米粒子，且通过普朗尼克F127的修饰提高其分散性并降低MnFe2O4纳米粒子的细胞毒性。方法：以F127为模版，采用共沉淀法制备MnFe2O4磁性纳米粒。利用X射线衍射(XRD)、透射电子显微镜(TEM)、振动样品磁强计(VSM)、傅立叶变换红外光谱(FT-IR)等对样品的成分、微观结构、形貌和粒径以及磁性能进行表征。通过MTT实验对样品的细胞毒性进行评价。结果：采用普朗尼克F127调控下的共沉淀法成功制备大约50 nm的球形MnFe2O4铁磁性纳米粒子，其比饱和磁化强度为44.8 emu/g，对HUVEC细胞无明显毒性。结论：共沉淀过程中，F127能够控制MnFe2O4纳米粒子的形貌、粒径，从而提高其磁性能，另外还可以降低其细胞毒性。该方法在生物医学应用上具有很大的潜力。
MnFe2O4 nanoparticles have great potentials in Magnetic Resonance Imaging and tumor hyper-thermia. However for biomedical applications, the main challenges would be of great difficulty to synthesize MnFe
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