Penthorum chinense Pursh is rich in gallic acid, which has antioxidant, anti-inflammatory, anti-fungal and antitumor activities. In order to optimize their extraction conditions, various extraction parameters were chosen to identify their effects on gallic acid extraction. With extraction amount of gallic acid as index, based on single factor analysis, influence of solid/liquid ratio, ethanol concentration, fetch time and extraction temperature on extraction technology were investigated by orthogonal test. The optimization conditions for gallic acid extraction were determined as follows: ethanol concentration 60%, extraction time 2.5 h, temperature 90°C and solid/liquid ratio 1:30. The corresponding gallic acid content was 4.85%. This optimized extraction process was stable and feasible.
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