In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner’s ratio, Carr’s index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by ATR-FTIR, XRD, DSC, and SEM techniques. Heckel and Kawakita models were applied to carry out compression studies for the prepared conjugates. Fast disintegrating tablets of domperidone were prepared using corn starch and corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrants in different concentrations. Conjugates were found to possess good powder flow and tabletting properties. Heckel analysis indicated that the conjugates prepared by microwave method showed the slowest onset of plastic deformation while Kawakita analysis indicated that the conjugates prepared by microwave method exhibited the highest amount of total plastic deformation. The study revealed that the corn Starch-Neusilin UFL2 conjugates possess improved powder flow properties and could be a promising superdisintegrant for preparing fast disintegrating tablet. Also, the results sugessted that the microwave method was found to be most effective for the preparation of corn Starch-Neusilin UFL2 conjugates. 1. Introduction Amongst innumerable applications, starch and its derivatives are one of the most widely used excipients in the pharmaceutical industry as they are incorporated in the manufacture of assorted dosage forms due to their biodegradability and biocompatibility. Starches have become a valuable ingredient because of their inertness, abundance, and cost effectiveness in the food industry, where they are used as thickeners, bulking, water retention, and gelling agents, in the pharmaceutical industry where they are used as fillers, binders, and disintegrants in tablet formulations. Commercially, starches are obtained from a variety of cereals (corn, waxy corn, high amylose corn, wheat, and various rice varieties) and from the tubers and roots (predominantly potato and cassava). In the pharmaceutical formulations, starch can be used both as a disintegrant and as a binder depending on the explicit attributes crucial for the formulation. As a disintegrant, the mechanism of action of starch includes wicking, the imbibitions of water into the tablet matrix via capillary action. The concentration of starch used is crucial; if it is below the optimum concentration then there are insufficient
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