It has been suggested that the left temporal pole (Brodmann area 38 (BA38)) participates in diverse language functions, including semantic processing, speech comprehension, and naming. Utilizing the activation likelihood estimation (ALE), a meta-analytic connectivity study was conducted to further our understanding on the role of BA38 in language. Departing from the BrainMap functional database, 11 papers corresponding to 12 paradigms including 201 participants were selected. Initially, was employed as the significance level, resulting in the presence of four different activation clusters. However, when the significance level was lowered to , sixteen activation clusters appeared, including classical language areas such as Broca’s and Wernicke’s areas. It was concluded that (1) this meta-analytic connectivity study suggests the presence of two major connection circuits involving BA38; one is related to language, while the other may be involved in visuospatial and integrative audiovisual functions. Furthermore, (2) BA38 also contributes to various brain networks supporting linguistic processes related not only to language comprehension but also to language production. 1. Introduction The temporal lobe is a particularly complex brain area involved in a diversity of functions, some of which include auditory, olfactory, memory, vestibular, visual, and linguistic processing [1, 2]. With regard to other primates, the temporal lobe is the largest in humans representing about 17% of the cerebral cortex [3]. The temporal pole (Brodmann area 38; BA38) represents no more than 10% of total temporal lobe volume and about 1.7% of the cerebral cortex. Due to its sizeable nature, several subareas have been distinguished in the temporal pole. Pascual et al. [4] proposed separation possibilities between different cytoarchitectonic subfields: (1) dorsal, with predominant connectivity to auditory/somatosensory and language networks; (2) ventromedial, predominantly connected to visual networks; (3) medial, connected to paralimbic structures; and (4) anterolateral, connected to the default-semantic network. Consequently, significant language roles of BA38 are assumed. The specific linguistic role of the left temporal pole remains elusive. Regardless of its evident participation in the brain language system, the left BA38 is not usually included in Wernicke’s area. Nevertheless, various linguistic functions have been related to this brain area. Contemporary neuroimaging studies suggest that the left BA38 is involved in the following language-related functions: semantic
References
[1]
K. Kolb and I. Q. Whishaw, Fundamentals of Human Neuropsychology, Worth Publishers, New York, NY, USA, 6th edition, 2009.
[2]
L. R. Squire, C. E. L. Stark, and R. E. Clark, “The medial temporal lobe,” Annual Review of Neuroscience, vol. 27, pp. 279–306, 2004.
[3]
J. A. Kiernan, “Anatomy of the temporal lobe,” Epilepsy Research and Treatment, vol. 2012, Article ID 176157, 12 pages, 2012.
[4]
B. Pascual, J. C. Masdeu, M. Hollenbeck et al., “Large-scale brain networks of the human left temporal pole: a functional connectivity MRI study,” Cerebral Cortex, 2013.
[5]
U. Noppeney and C. J. Price, “Retrieval of visual, auditory, and abstract semantics,” NeuroImage, vol. 15, no. 4, pp. 917–926, 2002.
[6]
U. Noppeney and C. J. Price, “A PET study of stimulus- and task-induced semantic processing,” NeuroImage, vol. 15, no. 4, pp. 927–935, 2002.
[7]
C. Palliera, A.-D. Devauchellea, and S. Dehaenea, “Cortical representation of the constituent structure of sentences,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 6, pp. 2522–2527, 2011.
[8]
R. Vandenberghe, A. C. Nobre, and C. J. Price, “The response of left temporal cortex to sentences,” Journal of Cognitive Neuroscience, vol. 14, no. 4, pp. 550–560, 2002.
[9]
L. Tomaszewki, S. Farias, G. Harrington, C. Broomand, and M. Seyal, “Differences in functional MR imaging activation patterns associated with confrontation naming and responsive naming,” American Journal of Neuroradiology, vol. 26, no. 10, pp. 2492–2499, 2005.
[10]
T. J. Grabowski, H. Damasio, D. Tranel, L. L. Boles Ponto, R. D. Hichwa, and A. R. Damasio, “A role for left temporal pole in the retrieval of words for unique entities,” Human Brain Mapping, vol. 13, no. 4, pp. 199–212, 2001.
[11]
K. Hoenig and L. Scheef, “Mediotemporal contributions to semantic processing: fMRI evidence from ambiguity processing during semantic context verification,” Hippocampus, vol. 15, no. 5, pp. 597–609, 2005.
[12]
U. Kumar, P. Padakannaya, R. K. Mishra, and C. L. Khetrapal, “Distinctive neural signatures for negative sentences in Hindi: an fMRI study,” Brain Imaging and Behavior, vol. 7, no. 2, pp. 91–101, 2013.
[13]
J. T. Crinion, E. A. Warburton, M. A. Lambon-Ralph, D. Howard, and R. J. S. Wise, “Listening to narrative speech after aphasic stroke: the role of the left anterior temporal lobe,” Cerebral Cortex, vol. 16, no. 8, pp. 1116–1125, 2006.
[14]
E. A. Maguire, C. D. Frith, and R. G. Morris, “The functional neuroanatomy of comprehension and memory: the importance of prior knowledge,” Brain, vol. 122, no. 10, pp. 1839–1850, 1999.
[15]
N. Tzourio, B. Nkanga-Ngila, and B. Mazoyer, “Left planum temporale surface correlates with functional dominance during story listening,” NeuroReport, vol. 9, no. 5, pp. 829–833, 1998.
[16]
B. Straube, Y. He, M. Steines et al., “Supramodal neural processing of abstract information conveyed by speech and gesture,” Frontiers in Behavioral Neuroscience, vol. 7, article 120, 2013.
[17]
S. Magnusdottir, P. Fillmore, D. B. den Ouden et al., “Damage to left anterior temporal cortex predicts impairment of complex syntactic processing: a lesion-symptom mapping study,” Human Brain Mapping, vol. 34, no. 10, pp. 2715–2723, 2013.
[18]
K. Patterson, P. J. Nestor, and T. T. Rogers, “Where do you know what you know? The representation of semantic knowledge in the human brain,” Nature Reviews Neuroscience, vol. 8, no. 12, pp. 976–987, 2007.
[19]
W. K. Simmons and A. Martin, “The anterior temporal lobes and the functional architecture of semantic memory,” Journal of the International Neuropsychological Society, vol. 15, no. 5, pp. 645–649, 2009.
[20]
D. Tranel, H. Damasio, and A. R. Damasio, “A neural basis for the retrieval of conceptual knowledge,” Neuropsychologia, vol. 35, no. 10, pp. 1319–1327, 1997.
[21]
D. Tranel, “Impaired naming of unique landmarks is associated with left temporal polar damage,” Neuropsychology, vol. 20, no. 1, pp. 1–10, 2006.
[22]
K. Tsapkini, C. E. Frangakis, and A. E. Hillis, “The function of the left anterior temporal pole: evidence from acute stroke and infarct volume,” Brain, vol. 134, no. 10, pp. 3094–3105, 2011.
[23]
L. Rami, C. Caprile, B. Gómez-Ansón, et al., “Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases,” Dementia and Geriatric Cognitive Disorders, vol. 25, no. 3, pp. 212–217, 2008.
[24]
C. Papagno, “Naming and the role of the uncinate fasciculus in language function,” Current Neurology and Neuroscience Reports, vol. 11, no. 6, pp. 553–559, 2011.
[25]
I. P. Martins and L. Farrajota, “Proper and common names: a double dissociation,” Neuropsychologia, vol. 45, no. 8, pp. 1744–1756, 2007.
[26]
J. K. Olofsson, E. Rogalski, T. Harrison, M.-M. Mesulam, and J. A. Gottfried, “A cortical pathway to olfactory naming: evidence from primary progressive aphasia,” Brain, vol. 136, no. 4, pp. 1245–1259, 2013.
[27]
S. J. Carrington and A. J. Bailey, “Are there theory of mind regions in the brain? A review of the neuroimaging literature,” Human Brain Mapping, vol. 30, no. 8, pp. 2313–2335, 2009.
[28]
F. Van Overwalle, “Social cognition and the brain: a meta-analysis,” Human Brain Mapping, vol. 30, no. 3, pp. 829–858, 2009.
[29]
C. Michel, L. Dricot, R. Lhommel et al., “Extensive left temporal pole damage does not impact on theory of mind abilities,” Journal of Cognitive Neuroscience, vol. 25, no. 12, pp. 2025–2046, 2013.
[30]
N. Makris, M. G. Preti, D. Wassermann et al., “Human middle longitudinal fascicle: segregation and behavioral-clinical implications of two distinct fiber connections linking temporal pole and superior temporal gyrus with the angular gyrus or superior parietal lobule using multi-tensor tractography,” Brain Imaging and Behavior, vol. 7, no. 3, pp. 335–352, 2013.
[31]
N. Makris, M. G. Preti, T. Asami, et al., “Human middle longitudinal fascicle: variations in patterns of anatomical connections,” Brain Structure and Function, vol. 218, no. 4, pp. 951–968, 2013.
[32]
N. Menjot De Champfleur, I. Lima Maldonado, S. Moritz-Gasser et al., “Middle longitudinal fasciculus delineation within language pathways: a diffusion tensor imaging study in human,” European Journal of Radiology, vol. 82, no. 1, pp. 151–157, 2013.
[33]
J. R. Augustine, “Circuitry and functional aspects of the insular lobe in primates including humans,” Brain Research Reviews, vol. 22, no. 3, pp. 229–244, 1996.
[34]
H. Ackermann and A. Riecker, “The contribution of the insula to motor aspects of speech production: a review and a hypothesis,” Brain and Language, vol. 89, no. 2, pp. 320–328, 2004.
[35]
A. Ardila, “The role of insula in language: an unsettled question,” Aphasiology, vol. 13, no. 1, pp. 79–87, 1999.
[36]
A. Ardila, D. F. Benson, and F. G. Flynn, “Participation of the insula in language,” Aphasiology, vol. 11, no. 12, pp. 1159–1169, 1997.
[37]
A. Ardila, B. Bernal, and M. Rosselli, “Participation of the insula in language revisited: a meta-analytic connectivity study,” Journal of Neurolinguistics, vol. 29, no. 1, pp. 31–41, 2014.
[38]
A. S. Dick, B. Bernal, and P. Tremblay, “The language connectome: new pathways, new concepts,” Neuroscientist, vol. 20, no. 5, pp. 453–467, 2014.
[39]
J. L. Robinson, A. R. Laird, D. C. Glahn, W. R. Lovallo, and P. T. Fox, “Metaanalytic connectivity modeling: delineating the functional connectivity of the human amygdala,” Human Brain Mapping, vol. 31, no. 2, pp. 173–184, 2010.
[40]
A. R. Laird, P. M. Fox, C. J. Price et al., “ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts,” Human Brain Mapping, vol. 25, no. 1, pp. 155–164, 2005.
[41]
P. E. Turkeltaub, G. F. Eden, K. M. Jones, and T. A. Zeffiro, “Meta-analysis of the functional neuroanatomy of single-word reading: method and validation,” NeuroImage, vol. 16, no. 3, part 1, pp. 765–780, 2002.
[42]
http://brainmap.org/.
[43]
U. Noppeney and C. J. Price, “Retrieval of abstract semantics,” NeuroImage, vol. 22, no. 1, pp. 164–170, 2004.
[44]
E. A. Kensinger and D. L. Schacter, “Amygdala activity is associated with the successful encoding of item, but not source, information for positive and negative stimuli,” Journal of Neuroscience, vol. 26, no. 9, pp. 2564–2570, 2006.
[45]
S. S. Ghosh, J. A. Tourville, and F. H. Guenther, “A neuroimaging study of premotor lateralization and cerebellar involvement in the production of phonemes and syllables,” Journal of Speech, Language, and Hearing Research, vol. 51, no. 5, pp. 1183–1202, 2008.
[46]
A. P. Leff, T. M. Schofield, K. E. Stephan, J. T. Crinion, K. J. Friston, and C. J. Price, “The cortical dynamics of intelligible speech,” Journal of Neuroscience, vol. 28, no. 49, pp. 13209–13215, 2008.
[47]
W. K. Simmons, S. B. Hamann, C. L. Harenski, X. P. Hu, and L. W. Barsalou, “fMRI evidence for word association and situated simulation in conceptual processing,” Journal of Physiology, vol. 102, no. 1–3, pp. 106–119, 2008.
[48]
M. M. Benoit, T. Raij, F.-H. Lin, I. P. J??skel?inen, and S. Stufflebeam, “Primary and multisensory cortical activity is correlated with audiovisual percepts,” Human Brain Mapping, vol. 31, no. 4, pp. 526–538, 2010.
[49]
J. R. Binder, D. A. Medler, R. Desai, L. L. Conant, and E. Liebenthal, “Some neurophysiological constraints on models of word naming,” NeuroImage, vol. 27, no. 3, pp. 677–693, 2005.
[50]
M. D. Lieberman, N. I. Eisenberger, M. J. Crockett, S. M. Tom, J. H. Pfeifer, and B. M. Way, “Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli,” Psychological Science, vol. 18, no. 5, pp. 421–428, 2007.
[51]
D. S. Sabsevitz, D. A. Medler, M. Seidenberg, and J. R. Binder, “Modulation of the semantic system by word imageability,” NeuroImage, vol. 27, no. 1, pp. 188–200, 2005.
[52]
L. F. De Nil, D. S. Beal, S. J. Lafaille, R. M. Kroll, A. P. Crawley, and V. L. Gracco, “The effects of simulated stuttering and prolonged speech on the neural activation patterns of stuttering and nonstuttering adults,” Brain and Language, vol. 107, no. 2, pp. 114–123, 2008.
[53]
E. A. Kensinger and D. L. Schacter, “Retrieving accurate and distorted memories: neuroimaging evidence for effects of emotion,” NeuroImage, vol. 27, no. 1, pp. 167–177, 2005.
[54]
K. Emmorey, T. Grabowski, S. McCullough et al., “Neural systems underlying lexical retrieval for sign language,” Neuropsychologia, vol. 41, no. 1, pp. 85–95, 2003.
G. J. Parker, S. Luzzi, D. C. Alexander, C. A. Wheeler-Kingshott, O. Ciccarelli, and M. Lambon Ralph, “Lateralization of ventral and dorsal auditory-language pathways in the human brain,” NeuroImage, vol. 24, no. 3, pp. 656–666, 2005.
[57]
J. P. Rauschecker and S. K. Scott, “Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing,” Nature Neuroscience, vol. 12, no. 6, pp. 718–724, 2009.
[58]
S. Hsieh, M. Hornberger, O. Piguet, and J. R. Hodges, “Brain correlates of musical and facial emotion recognition: evidence from the dementias,” Neuropsychologia, vol. 50, no. 8, pp. 1814–1822, 2012.
[59]
L. Pizzamiglio, T. Aprile, G. Spitoni et al., “Separate neural systems for processing action- or non-action-related sounds,” NeuroImage, vol. 24, no. 3, pp. 852–861, 2005.
[60]
R. D. Lane and L. Nadel, Cognitive Neuroscience of Emotion, Oxford University Press, New York, NY, USA, 2000.
[61]
D. Wildgruber, H. Ackermann, B. Kreifelts, and T. Ethofer, “Chapter 13 Cerebral processing of linguistic and emotional prosody: fMRI studies,” Progress in Brain Research, vol. 156, pp. 249–268, 2006.
[62]
T. Ethofer, S. Anders, M. Erb, et al., “Cerebral pathways in processing of affective prosody: a dynamic causal modeling study,” NeuroImage, vol. 30, no. 2, pp. 580–587, 2006.