Purpose: To evaluate age
related ovarian response to controlled ovarian hyperstimulation, clinical
pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing
assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels
of <5 pmol/l. Methods: Retrospective analysis of data from 63 women with AMH
of <5 pmol/L who underwent their first assisted reproduction treatment (In-vitrofertilization, IVF and
intracytoplasmic sperm injection, ICSI) cycle. Results were analyzed after
dividing patients in two groups, group 1 included women of ≤38 years and group
2 > 38 years of age. Non parametric variables were expressed as median (Interquartile
range) and compared by Kruskal-Wallis test. Categorical variables were
expressed as numbers with proportions (%) and compared by Fisher’s exact test.
Results: There was no statistical difference in body max index, level of
antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of
gonadotrophins used and cycles cancellation rate in two groups. Although number
of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing
pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no
statistical difference between the two groups. There was one miscarriage in
group 2. Conclusion: Women with extremely low-serum AMH levels can still have
clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances
will be lower than women with normal ovarian reserve.
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