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Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

DOI: 10.1155/2014/545170

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Caloric restriction and environmental enrichment have been separately reported to possess health benefits such as improvement in motor and cognitive functions. Resveratrol, a natural polyphenolic compound, has been reported to be caloric restriction mimetic. This study therefore aims to investigate the potential benefit of the combination of resveratrol as CR and EE on learning and memory, motor coordination, and motor endurance in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I animals received carboxymethylcellulose (CMC) orally per kg/day (control), group II animals were maintained on every other day feeding, group III animals received resveratrol 50?mg/kg, suspended in 10?g/L of (CMC) orally per kg/day, group IV animals received CMC and were kept in an enriched environment, and group V animals received resveratrol 50?mg/kg and were kept in EE. The treatment lasted for four weeks. On days 26, 27, and 28 of the study period, the animals were subjected to neurobehavioural evaluation. The results obtained showed that there was no significant change in neurobehavioural responses in all the groups when compared to the control which indicates that 50?mg/kg of resveratrol administration and EE have no significant effects on neurobehavioural responses in young healthy mice over a period of four weeks. 1. Introduction Dietary restriction (DR), otherwise known as caloric restriction (CR), has been generally defined as consumption of nutritious diet that is 30% to 40% less in calories compared to ad libitum diet [1]. In other words, CR can be defined as a simple reduction in caloric intake in the absence of malnutrition [2]. Caloric restriction has been demonstrated to possess many health benefits. It provides protection against numerous deadly diseases such as cancer, neurological disorders, and obesity and is found to be the only reliable treatment that extends lifespan or causes healthy aging consistently in a multitude of organisms ranging from bacteria to monkeys [3–5]. The most frequently mentioned effect of CR has been its influence on creating a mild stress in the organism and a typical upregulation of adaptive mechanisms involving stress proteins accompanied by elevated defence or survival molecules [6]. Caloric restriction (CR) has also been found to retard several aspects of the aging process in mammals, including age-related mortality, tumorigenesis, physiological decline [7], and the establishment of age-related transcriptional profiles [8]. Resveratrol (3,5′,4-trihydroxystilbene), a


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