全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors

DOI: 10.3389/fimmu.2013.00299

Keywords: antigen processing, MHC class II, endosomal proteases, intracellular toll-like receptors

Full-Text   Cite this paper   Add to My Lib

Abstract:

MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells, and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells. However, to elicit CD4+-T cells immunity, pAPCs need an additional signal, which can be delivered by toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular TLRs in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133