Possibilities
of synchronized oscillations in glycolysis mediated by various extracellular
metabolites are investigated theoretically using two-dimensional
reaction-diffusion systems, which originate from the existing seven-variable
model. Our simulation results indicate the existence of alternative mediators
such as ATP and 1,3-bisphosphoglycerate, in addition to already known acetaldehyde
or pyruvate. Further, it is also suggested that the alternative intercellular
communicator plays a more important role in the respect that these can
synchronize oscillations instantaneously not only with difference phases but
also with different periods. Relations between intercellular coupling and
synchronization mechanisms are also analyzed and discussed by changing the
values of parameters such as the diffusion coefficient and the cell density
that can reflect in tercellular coupling strength.
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