We investigated respiratory
tumor motion in lung stereotactic body radiotherapy (SBRT) with use of the “Air-Bag
System”. 114 patients underwent four-dimensional (4D) computed tomography (CT)
from October 2010 to April 2012. Gross tumor volume (GTV) was 8.1 ± 11.0 cc (range
0.3 - 77.5 cc). The tumor site was the upper and middle lobes in 62 cases, and
lower lobe in 52 cases. The Air-Bag SystemTM consists of an inelastic
air bag connected to a second smaller elastic air bag. The inelastic air bag is
placed between the patient’s body surface and a HipFix and is secured by
pressure adjustment via the elastic air bag. To assess respiratory tumor
motion, the centroid of the tumor position is measured in the left-right,
anterior-posterior, and caudal-cranial directions using the iPlan RT DoseTM treatment planning system. Respiratory tumor motion vector for patients with
upper/middle and lower lobe tumors was 3.0 ± 2.2 mm (range, 0.4 - 11.7 mm) and
6.5 ± 4.6 mm (range, 0.4 - 22.0 mm) respectively, with this difference being
significant (p < 0.05). Mean respiratory tumor motion for all patients was
0.9 ± 0.6 mm (range, 0.1 - 3.6 mm) in the left-right direction, 1.5 ± 1.1 mm (range,
0.1 - 5.7 mm) in the anterior-posterior direction, 4.1 ± 4.0 mm (range, 0.1 - 21.4
mm) in the caudal-cranial direction, and 4.7 ± 4.0 mm (range, 0.4 - 22.0 mm)
overall. The Air-Bag System is expected to be provided an effective reduction
in the motion of lung tumors.
References
[1]
Keall, P.J., Mageras, G.S., Balter, J.M., et al. (2006) The Management of Respiratory Motion in Radiation Oncology Report of AAPM Task Group 76. Medical Physics, 33, 3874-3900. http://dx.doi.org/10.1118/1.2349696
[2]
Mori, S., Endo, M., Komatsu, S., Yashiro, T., Kandatsu, S. and Baba, M. (2007) Four-Dimensional Measurement of Lung Tumor Displacement Using 256 Multi Slice CT Scanner. Lung Cancer, 56, 56-67. http://dx.doi.org/10.1016/j.lungcan.2006.11.011
[3]
Stevens, C.W., Munden, R.F., Forster, K.M., et al. (2001) Respiratory-Driven Lung Tumor Motion Is Independent of Tumor Size, Tumor Location, and Pulmonary Function. International Journal of Radiation Oncology, Biology, Physics, 51, 62-68.
[4]
Chen, Q.S., Weinhous, M.S., Deibel, F.C., Ciezki, J.P. and Macklis, R.M. (2001) Fluoroscopic Study of Tumor Motion Due to Breathing: Facilitating Precise Radiation Therapy for Lung Cancer Patients. Medical Physics, 28, 1850-1856. http://dx.doi.org/10.1118/1.1398037
[5]
Guckenberger, M., Meyer, J., Wilbert, J., et al. (2006) Cone-Beam CT Based Image-Guidance for Extracranial Stereotactic Radiotherapy of Intrapulmonary Tumors. Acta Oncologica, 45, 897-906. http://dx.doi.org/10.1080/02841860600904839
[6]
ICRU (1993) Prescribing, Recording, and Reporting Photon Beam Therapy. ICRU Report Volume 50, International Commission on Radiation Units and Measurements, Bethesda.
[7]
Seppenwoolde, Y., Lebesque, J.V., De Jaeger, K., et al. (2003) Comparing Different NTCP Models That Predict the Incidence of Radiation Pneumonitis. Normal Tissue Complication Probability. International Journal of Radiation Oncology, Biology, Physics, 55, 724-735.
[8]
Mageras, G.S. and Yorke, E. (2004) Deep Inspiration Breath Hold and Respiratory Gating Strategies for Reducing Organ Motion in Radiation Treatment. Seminars in Radiation Oncology, 14, 65-75. http://dx.doi.org/10.1053/j.semradonc.2003.10.009
[9]
Negoro, Y., Nagata, Y., Aoki, T., et al. (2001) The Effectiveness of an Immobilization Device in Conformal Radiotherapy for Lung Tumor: Reduction of Respiratory Tumor Movement and Evaluation of the Daily Setup Accuracy. International Journal of Radiation Oncology, Biology, Physics, 50, 889-898.
[10]
Miura, H., Masai, N., Oh, R.J., Shiomi, H., Sasaki, J. and Inoue, T. (2013) Approach to Dose Prescription of the Gross Tumor Volume for Lung Cancer with Respiratory Tumor Motion. Journal of Radiation Research, 54, 140-145. http://dx.doi.org/10.1093/jrr/rrs054
[11]
Hanley, J., Debois, M.M., Mah, D., et al. (1999) Deep Inspiration Breath-Hold Technique for Lung Tumors: The Potential Value of Target Immobilization and Reduced Lung Density in Dose Escalation. International Journal of Radiation Oncology, Biology, Physics, 45, 603-611.
[12]
Liu, H.H., Balter, P., Tutt, T., et al. (2007) Assessing Respiration-Induced Tumor Motion and Internal Target Volume Using Four-Dimensional Computed Tomography for Radiotherapy of Lung Cancer. International Journal of Radiation Oncology, Biology, Physics, 68, 531-540.
[13]
Han, K., Cheung, P., Basran, P.S., Poon, I., Yeung, L. and Lochray, F. (2010) A Comparison of Two Immobilization Systems for Stereotactic Body Radiation Therapy of Lung Tumors. Radiotherapy & Oncology, 95, 103-108. http://dx.doi.org/10.1016/j.radonc.2010.01.025
[14]
Ko, Y.E., Suh, Y., Ahn, S.D., et al. (2005) Immobilization Effect of Air-Injected Blanket (AIB) for Abdomen Fixation. Medical Physics, 32, 3363-3366. http://dx.doi.org/10.1118/1.2047783
[15]
Seppenwoolde, Y., Shirato, H., Kitamura, K., et al. (2002) Precise and Real-Time Measurement of 3D Tumor Motion in Lung Due to Breathing and Heartbeat, Measured during Radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 53, 822-834.
[16]
Onishi, H., Kawakami, H., Marino, K., et al. (2010) A Simple Respiratory Indicator for Irradiation during Voluntary Breath Holding: A One-Touch Device without Electronic Materials. Radiology, 255, 917-923. http://dx.doi.org/10.1148/radiol.10090890
[17]
George, R., Ramakrishnan, V., Siebers, J.V., Chung, T.D. and Keall, P.J. (2006) Investigation of Patient, Tumour and Treatment Variables Affecting Residual Motion for Respiratory-Gated Radiotherapy. Physics & Medicine in Biology, 51, 5305-5319. http://dx.doi.org/10.1088/0031-9155/51/20/015
[18]
George, R., Chung, T.D., Vedam, S.S., et al. (2006) Audio-Visual Biofeedback for Respiratory-Gated Radiotherapy: Impact of Audio Instruction and Audio-Visual Biofeedback on Respiratory-Gated Radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 65, 924-933.
[19]
Eccles, C.L., Patel, R., Simeonov, A.K., Lockwood, G., Haider, M. and Dawson, L.A. (2011) Comparison of Liver Tumor Motion with and without Abdominal Compression Using Cine-Magnetic Resonance Imaging. International Journal of Radiation Oncology, Biology, Physics, 79, 602-608.