Esfenvalerate belongs to the
pyrethroid group of insecticides which display significant selective toxicity
against insects compared to mammalian species, nevertheless, they may pose health risks, especially in case of accidental
exposure. The aim of the present study was to model the effect of acute,
relatively high-dose exposure of the esfenvalerate-containing formulation
Sumi-Alpha?. Eventual functional alterations in the central nervous
system and in the gastrointestinal tract were studied on invitro tissue preparations at different delays after intragastric administration to
rats. Neuronal effects were characterized by field potential recording in
cortical and hippocampal brain slices, while gastrointestinal effects were
examined by analyzing the motility and excitability
of isolated ileum segments. On the brain slices originating from
esfenvalerate-treated animals, changes in excitability of both inhibitory and
excitatory type could be observed. Voltage thresholds
necessary to evoke responses in neocortex slices were elevated,and population spike am
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