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Effects of Darbepoetin-α on Oxidative Stress Marker in Patients with Chronic Renal Failure

DOI: 10.4236/ojneph.2014.41002, PP. 8-12

Keywords: Chronic Renal Failure, Darbepoetin-α, Epoetin-α, Indoxyl Sulfate, MDA-LDL, Renal Anemia

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Abstract:

Objective: Long-acting darbepoetin (DA) has recently been used to treat renal anemia in patients with chronic renal failure. It is considered clinically useful because its duration of action is longer than that of conventional epoetin. In this study, we investigated changes in the levels of the oxidative stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL), renal anemia, and renal function when patients were treated for chronic renal failure switched from epoetin to DA. Materials and Methods: The subjects included nine patients with chronic renal failure and renal anemia who were treated with epoetin on an outpatient basis at our department. Blood was sampled prior to the switch and at 3, 6, and 12 months after the switch. We then investigated changes in MDA-LDL, hemoglobin (Hb), and creatinine (Cr) levels.

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