Objective:
To explore the effects of Anwei decoction (AD) on the protein expression of TFF
in rats with chronic atrophic gastritis(CAG). Methods: Forty-eight healthy rats
were randomly divided into 4 groups: normal control group, pathologic model
group, Anwei Decoction group, and Weifuchun group. CAG was induced in rats with
N-methy-N-nitro-N-nitrogua-nidine (MNNG). The protein expression of TFF in
rats’ gastric mucosa was determined by immunohistochemistry. Results: Compared
with that in the normal control group, the protein expression of TFF1 was
significantly enhanced in the pathologic model, Anwei Decoction and Weifuchun
groups (both P < 0.01). The protein expression level of TFF1 was significantly higher in the Anwei Decoction
group than in the Weifuchun group (P < 0.01). Compared with the normal
control group, the protein expression of TFF2 was significantly enhanced in the
pathologic model, Anwei Decoction and Weifuchun groups (both P < 0.01). The
protein expression level of TFF2 was significantly higher in the Anwei
Decoction group than in the Weifuchun group (P < 0.01). In comparison with
the pathologic model group, the protein
expression of TFF3 was remarkably reduced in Anwei Decoction and
Weifuchun groups (both P < 0.01). but there was no difference between the
group of Anwei decoction and the group of Weifuchun (P > 0.05). Conclusion:
Anwei decoction may be effective in the treatment of CAG by enhancing the
protein expression of TFF1, TFF2 while reducing that of TFF3 in gastric mucosas.
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