The Skeletal Muscle Impedancemetric Characteristics as a Marker for Detection of Functional State of Organism

Previously it has been shown that cell hydration is a universal and extrasensitive marker for different environmental mediums and functional state of tissue and organism. The comparative study of cell hydration of different organs (brain cortex, liver, and skeletal muscle) at various experimental conditions (microstress, pathology, and different poisons) was realized. It was shown that among tissues of different organs muscle hydration is more sensitive to any change of functional state of organism and environmental medium. The study of correlation between tissue muscle hydration and double-frequency measurement impedance method indicated that the differences between muscle reactive conductivity measured at high frequency (HF) and low frequency (LF) could be an adequate marker for detection of muscle hydration. The animal poisoning, stress, and pathology-induced tissue hydration were accompanied by increase in . The observed close correlation between time-dependent tissue hydration and in different environmental mediums can be a marker for detection of postmortal period as well as for characterizing environmental medium of the corpse. 1. Introduction At present when technical progress brings the humanity to ecological catastrophe, the adequate detection of environmental pollution from the point of public health has become one of the problems of modern life sciences. The main barrier to solve this problem is that the biological effect of physical and chemical signals on organism cannot be detected only by using their physical parameters because their effect depends on environmental, chemical, and physical characteristics, as well as on functional state of organism. Therefore, only the biological marker of cell and organism could serve as adequate impact of environmental factors on organism. At present it is well established that metabolic controlling of cell hydration determining its functional activity is a universal and extrasensitive parameter for physical and chemical factors [1–3]. The existence of water-transporting protein channels in membrane makes the cell volume extremely variable to osmotic gradients on membrane [4]. However, which of tissues is more sensitive to environmental and functional state changing and could serve as a marker for detection of functional state of organism is not clear yet. It was suggested that the elaboration method of express detection of tissue hydration could serve as a novel diagnostic method for estimation of functional state of organism as well as for detection of postmortal period. Therefore, the following