ON THE NOVEL INHIBITORY ACTION OF MUSHROOM EXTRACT OF CORIOLUS VERSICOLOR AND IT’S BIOACTIVITY AGAINST DRUG RESISTANT BACTERIA SALMONELLA TYPHIMURIUM (MTCC 3241)

The aim of this study was to investigate the effects of the mushroom extract of Coriolus versicolor on drug resistant strain of S. typhimurium experimental results revealed that hot water ethanol extract and Tris- HCl ethanol extract of C. versicolor were not only effective against drug resistant strain of S.typhimurium (MTCC 3214) but also against other pathogenic microorganisms such as K. pneumoniae, S. typhi, E. coli, S. pyogenes and Aspergillus niger. The extracts exerted their effects on the microorganisms by inhibiting their growth.The optimum temperature and pH conditions for mycelial growth of C. versicolor were found to be 28±1oC and 5.98 pH respectively. Maximum mycelial growth was observed by employing starch and ammonium sulphate as carbon and nitrogen source and on supplementing the cultivation medium with 20% (v/v) culture filtrate of C. versicolor. The present investigation highlights optimization of culture conditions and determination of antimicrobial spectrum C. versicolor .This indicate that the extracts of C. versicolor is a novel inhibitory source against drug resistant bacteria salmonella typhimurium.