Optimization of Cultural Conditions for the Production of Antibiotic by Streptomyces sp. VRY-1

Streptomyces sp. VRY-1 was screened for its bioactive potentials against various pathogenic microorganisms and was found to possess antibacterial activity against Salmonella typhimurium (drug resistant strain of bacteria) and various other pathogenic bacteria and fungi. Optimization of cultural conditions for production of antibiotic showed that maximum antibiotic production occurred on 10th day in stationary cultural, 28？？ C, 8.0 pH, liver extract, 1.5%(w/v) glucose. The bioactive compound was found to be soluble in water and ethyl acetate.