In the present study, the methanolic extract of Moringa oleifera leaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27？mg/dL), which led to an increase in the body weight (225？gr), total cholesterol, triglycerides (263.0 ± 4.69？mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20？mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant ( ) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant ( ) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200？mg and 400？mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated with Moringa oleifera (MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders. 1. Introduction Nowadays Obesity has emerged as a major health problem and risk factor for various disorders worldwide [1]. Overweight and obesity are defined as abnormal or excessive fat accumulation triggered by disproportion in energy intake and expenditure [2–4]. In addition to this attenuation in adipogenesis and over expression of pancreatic lipase enzyme which plays a pivotal role in progression of obesity [5]. The literature review revealed that alteration in dietary habit and less physical exercises, too, increase the frequency of obesity and related disorders [6, 7]. Further, obesity has been found to be associated with various disorders such as osteoarthritis [8], ischemic heart diseases (IHD) [8], atherosclerosis, diabetes, and hypertension [9–11]. A streak of evidence indicates that serotonin, histamine, dopamine, and their associated receptor activities are closely associated with obesity regulation [5]. Most importantly, strong evidences are available that elicited the role of leptin, ghrelin, and neuropeptides in obesity [12–14]. Currently, no pharmacological treatment provides sustained weight loss with minimal adverse effects [15, 16]. Thus, attempts have been made to reduce body weight with such pharmacological intervention that
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