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PLOS ONE  2014 

Chronic Pain and Mortality: A Systematic Review

DOI: 10.1371/journal.pone.0099048

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Abstract:

Background Chronic pain is common, often widespread and has a substantial impact on health and quality of life. The relationship between chronic pain and mortality is unclear. This systematic review aimed to identify and evaluate evidence for a relationship between chronic pain and mortality. Methods A search of ten electronic databases including EMBASE and MEDLINE was conducted in March 2012, and updated until March 2014. Observational studies investigating the association between chronic or widespread pain (including fibromyalgia) and mortality were included. Risk of bias was assessed and a meta-analysis was undertaken to quantify heterogeneity and pool results. A narrative review was undertaken to explore similarities and differences between the included studies. Results Ten studies were included in the review. Three reported significant associations between chronic or widespread pain and mortality in unadjusted results. In adjusted analyses, four studies reported a significant association. The remaining studies reported no statistically significant association. A meta-analysis showed statistically significant heterogeneity of results from studies using comparable outcome measures (n = 7)(I2 = 78.8%) and a modest but non-significant pooled estimate (MRR1.14,95%CI 0.95–1.37) for the relationship between chronic pain and all-cause mortality. This association was stronger when analysis was restricted to studies of widespread pain (n = 5,I2 = 82.3%) MRR1.22(95%CI 0.93–1.60). The same pattern was observed with deaths from cancer and cardiovascular diseases. Heterogeneity is likely to be due to differences in study populations, follow-up time, pain phenotype, methods of analysis and use of confounding factors. Conclusion This review showed a mildly increased risk of death in people with chronic pain, particularly from cancer. However, the small number of studies and methodological differences prevented clear conclusions from being drawn. Consistently applied definitions of chronic pain and further investigation of the role of health, lifestyle, social and psychological factors in future studies will improve understanding of the relationship between chronic pain and mortality.

 References

[1]  Woolf AD, Erwin J, March L (2012) The need to address the burden of musculoskeletal conditions. Best Pract Res Clin Rheumatol 26: 183–224. Elsevier website. Available: http://linkinghub.elsevier.com/retrieve/？pii/S1521694212000368. Accessed 2012 July 16.
[2]  McBeth J, Jones K (2007) Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 21: 403–425. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/17602？991. Accessed 2013 June 3.
[3]  Kamaleri Y, Natvig B, Ihlebaek CM, Bruusgaard D (2008) Localized or widespread musculoskeletal pain: does it matter? Pain 138: 41–46. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/18077？092. Accessed 2012 Aug 20.
[4]  Bergman S (2005) Psychosocial aspects of chronic widespread pain and fibromyalgia. Disabil Rehabil 27: 675–683. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16012？060. Accessed 2013 July 5.
[5]  Penttinen J (1994) Back pain and risk of fatal ischaemic heart disease: 13 year follow up of Finnish farmers. BMJ 309: 1267–1268. BMJ website. Available: http://www.bmj.com/content/309/6964/1267？.short. Accessed 2012 Aug 29.
[6]  Heli？vaara M, M？kel？ M, Aromaa A, Impivaara O, Knekt P, Reunanen A, (1995) Low back pain and subsequent cardiovascular mortality. Spine (Phila Pa 1976) 20: 2109–2111. PubMed website. Available: http://ukpmc.ac.uk/abstract/MED/8588167. Accessed 2012 Aug 29.
[7]  K？reholt I, Brattberg G (1998) Pain and mortality risk among elderly persons in Sweden. Pain 77: 271–278. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/98083？52. Accessed 2014.
[8]  Jordan K, Croft P (2010) Mortality and cancer in patients with new musculoskeletal episodes: a cohort study. Br J Gen Pract: 105–112. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pmc/articles？/PMC2828857/. Accessed 2012 Aug 29.
[9]  McBeth J, Symmons DP, Silman a J, Allison T, Webb R, et al. (2009) Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality. Rheumatology (Oxford) 48: 74–77. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=2639482&tool=pmcentrez？&rendertype=abstract. Accessed 2012 Aug 29.
[10]  Smith BH, Elliott AM, Hannaford PC (2003) Pain and subsequent mortality and cancer among women in the Royal College of General Practitioners Oral Contraception Study. Br J Gen Pract 53: 45–46. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=1314492&tool=pmcentrez？&rendertype=abstract. Accessed 2014 May.
[11]  Merskey H, Boduk N (1994) Classification of Chronic Pain. Seatle: International Association for the Study of Pain, IASP Press. IASP website. http://www.iasp-pain.org/files/Content/C？ontentFolders/Publications2/FreeBooks/Cl？assification-of-Chronic-Pain.pdf. Accessed 2014 May.
[12]  Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10: 287–333. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16095？934. Accessed 2012 July 15.
[13]  Carnes D, Parsons S, Ashby D, Breen a, Foster NE, et al. (2007) Chronic musculoskeletal pain rarely presents in a single body site: results from a UK population study. Rheumatology (Oxford) 46: 1168–1170. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/17488？750. Accessed 2012 Aug 20.
[14]  Croft P, Rigby AS, Boswell R, Schollum J, Silman A The prevalence of chronic widespread pain in the general population. J Rheumatol 20: 710–713. Refdoc website. Available: http://cat.inist.fr/?aModele=afficheN&cp？sidt=4695935. Accessed 16 April 2014.
[15]  Hunt IM, Silman A J, Benjamin S, McBeth J, Macfarlane GJ (1999) The prevalence and associated features of chronic widespread pain in the community using the “Manchester” definition of chronic widespread pain. Rheumatology (Oxford) 38: 275–279. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/10325？667. Accessed 2014 May.
[16]  Systematic reviews: CRD’s guidance for undertaking reviews in health care (2009). Centre for Reviews and Dissemination, University of York. University of York website. Available: http://www.york.ac.uk/inst/crd/pdf/Syste？matic_Reviews.pdf. Accessed 2014 May.
[17]  OpenGrey website. Available: http://www.opengrey.eu/. Accessed 2014 May.
[18]  Hayden J, C？té P, Bombardier C (2006) Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med: 427–438. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16549？855. Accessed 2014 May.
[19]  Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33: 159–174. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/84357？1. Accessed 2012 July 13.
[20]  Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557–560. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=192859&tool=pmcentrez&？rendertype=abstract. Accessed 2014 May.
[21]  DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177–188. PubMed website. Available: http://www.ncbi.nlm.nih.gov/pubmed/38028？33. Accessed 2014 May.
[22]  Ryan R (2014) Heterogeneity and subgroup analyses in Cochrane Consumers and Communication Review Group reviews: Planning the analysis at protocol stage. Cochrane Consum Commun Rev Gr 2014. Cochrane website. Available: http://cccrg.cochrane.org. Accessed 11 April 2014.
[23]  Dreyer L, Kendall S, Danneskiold-Sams？e B, Bartels EM, Bliddal H (2010) Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide. Arthritis Rheum 62: 3101–3108. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/20583？101. Accessed 2012 Aug 2.
[24]  Wolfe F, Hassett AL, Walitt B, Michaud K (2011) Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res (Hoboken) 63: 94–101. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/20662？040. Accessed 2012 Aug 29.
[25]  Sha MC, Callahan CM, Counsell SR, Westmoreland GR, Stump TE, et al. (2005) Physical symptoms as a predictor of health care use and mortality among older adults. Am J Med 118: 301–306. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/15745？729. Accessed 2012 Aug 17.
[26]  Khang Y, Kim H (2010) Gender differences in self-rated health and mortality association: role of pain-inducing musculoskeletal disorders. J Women’s Heal 19: 109–117. Mary Ann Liebert website. Available: http://online.liebertpub.com/doi/abs/10.？1089/jwh.2009.1413. Accessed 2012 Aug 29.
[27]  Elliott AM, Hannaford PC, Smith BH, Wyke S, Hunt K (2006) Symptom experience and subsequent mortality: results from the West of Scotland Twenty-07 study. BMC Health Serv Res 6: 158. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=1702541&tool=pmcentrez？&rendertype=abstract. Accessed 2012 Aug 29.
[28]  Ahmad R, Bath PA (2005) Identification of risk factors for 15-year mortality among community-dwelling older people using Cox regression and a genetic algorithm. J Gerontol A Biol Sci Med Sci 60: 1052–1058. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16127？112. Accessed 2014 May.
[29]  Maruta T, Malinchoc M, Offord KP, Colligan RC (1998) Status of patients with chronic pain 13 years after treatment in a pain management center. Pain 74: 199–204. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/95202？34. Accessed 2014 May.
[30]  Dreyer L, Mellemkjaer L, Kendall S, Jensen B, Danneskiold-Sams？e B, et al. (2007) Increased cancer risk in patients referred to hospital with suspected fibromyalgia. J Rheumatol 34: 201–206. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/17216？687. Accessed 2014 May.
[31]  Vandenkerkhof EG, Macdonald HM, Jones GT, Power C, Macfarlane GJ (2011) Diet, lifestyle and chronic widespread pain: results from the 1958 British Birth Cohort Study. Pain Res Manag 16: 87–92. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=3084409&tool=pmcentrez？&rendertype=abstract. Accessed 2014 May.
[32]  Andersson HI (2004) The course of non-malignant chronic pain: a 12-year follow-up of a cohort from the general population. Eur J Pain 8: 47–53. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/14690？674. Accessed 2012 Aug 29.
[33]  M？kel？ M, Heli？vaara M (1991) Prevalence of primary fibromyalgia in the Finnish population. BMJ 303: 216–219. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=1670522&tool=pmcentrez？&rendertype=abstract. Accessed 2014 May.
[34]  McBeth J, Silman AJ, Macfarlane GJ (2003) Association of widespread body pain with an increased risk of cancer and reduced cancer survival: a prospective, population-based study. Arthritis Rheum 48: 1686–1692. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/12794？837. Accessed 2012 Aug 29.
[35]  Nitter AK, Forseth K？ (2013) Mortality rate and causes of death in women with self-reported musculoskeletal pain: Results from a 17-year follow-up study. Scand J Pain 4: 86–92. Elsevier website. Available: http://linkinghub.elsevier.com/retrieve/？pii/S1877886012002443. Accessed 8 May 2013. Accessed 2014 May.
[36]  Torrance N, Elliott A, Lee AJ, Smith BH, (2010) Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study. Eur J Pain 14: 380–386. Wiley online website. Available: http://onlinelibrary.wiley.com/doi/10.10？16/j.ejpain.2009.07.006/full. Accessed 2012 Aug 29.
[37]  Andersson HI (2009) Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: a prospective population-based study. Disabil Rehabil 31: 1980–1987. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/19874？076. Accessed 2012 Aug 20.
[38]  Macfarlane GJ, McBeth J, Silman AJ (2001) Widespread body pain and mortality: prospective population based study. BMJ 323: 1–5. BMJ website. http://www.bmj.com/content/323/7314/662. Accessed 2014 May.
[39]  Sj？gren P, Gr？nb？k M, Peuckmann V & Ekholm O (2010) A population-based cohort study on chronic pain: the role of opioids. Clin J pain 26: 763–769. Lippincott Williams & Wilkins website. Available: http://journals.lww.com/clinicalpain/Abs？tract/2010/11000/A_Population_based_Coho？rt_Study_on_Chronic_Pain_.5.aspx. Accessed 2014 March 29.
[40]  Macfarlane GJ, Jones GT, Knekt P, Aromaa A, McBeth J, et al. (2007) Is the report of widespread body pain associated with long-term increased mortality? Data from the Mini-Finland Health Survey. Rheumatology (Oxford) 46: 805–807. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/17189？245. Accessed 2012 Aug 29.
[41]  Wolfe F, Smythe H, Yunus M, Bennett R, Bombardier C, et al. (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 33: 160–172. Wiley online website. Available: http://onlinelibrary.wiley.com/doi/10.10？02/art.1780330203/abstract. Accessed 2012 Aug 20.
[42]  Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, Katz RS, et al. (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62: 600–610. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/20461？783. Accessed 2012 July 12.
[43]  Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, H？user W, et al. (2011) Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia. J Rheumatol 38: 1113–1122. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/21285？161. Accessed 2013 July 24.
[44]  Tang NKY, Crane C (2006) Suicidality in chronic pain: a review of the prevalence, risk factors and psychological links. Psychol Med 36: 575–586. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16420？727. Accessed 2012 Aug 2.
[45]  Hochberg MC (2008) Mortality in osteoarthritis. Clin Exp Rheumatol 26: S120–4. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/19026？154. Accessed 2014 May.
[46]  Jordan KP, Hayward RA, Blagojevic-Bucknall M, Croft P (2013) Incidence of prostate, breast, lung and colorectal cancer following new consultation for musculoskeletal pain: a cohort study among UK primary care patients. Int J Cancer 133: 713–720. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=3708122&tool=pmcentrez？&rendertype=abstract. Accessed 2013 Sept 2.
[47]  Warburton DER, Nicol CW, Bredin SSD (2006) Health benefits of physical activity: the evidence. CMAJ 174: 801–809. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=1402378&tool=pmcentrez？&rendertype=abstract. Accessed 2014 May.
[48]  Alter DA, Naylor CD, Austin P, Tu J V (1999) Effects of socioeconomic status on access to invasive cardiac procedures and on mortality after acute myocardial infarction. N Engl J Med 341: 1359–1367. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/10536？129. Accessed 2014 May.
[49]  Greenland S, Pearl J, Robins JM (1999) Causal diagrams for epidemiologic research. Epidemiology 10: 37–48. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/98882？78. Accessed 2014 May.
[50]  Ray L, Lipton RB, Zimmerman ME, Katz MJ, Derby CA (2011) Mechanisms of association between obesity and chronic pain in the elderly. Pain 152: 53–59. PubMed website. Available: http://www.pubmedcentral.nih.gov/article？render.fcgi?artid=3004990&tool=pmcentrez？&rendertype=abstract. Accessed 2012 Sept 1.
[51]  Ditre JW, Brandon TH (2008) Pain as a motivator of smoking: effects of pain induction on smoking urge and behavior. J Abnorm Psychol 117: 467–472. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/18489？224. Accessed 2012 Aug 20.
[52]  Fagerstr？m K (2002) The epidemiology of smoking: health consequences and benefits of cessation. Drugs 62 Suppl 2: 1–9. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/12109？931. Accessed 2014 May.
[53]  Monninkhof EM, Elias SG, Vlems F a, van der Tweel I, Schuit AJ, et al. (2007) Physical activity and breast cancer: a systematic review. Epidemiology 18: 137–157. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/17130？685. Accessed 2012 July 16.
[54]  Liu Y, Hu F, Li D, Wang F, Zhu L, et al. (2011) Does physical activity reduce the risk of prostate cancer? A systematic review and meta-analysis. Eur Urol 60: 1029–1044. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/21802？197. Accessed 2012 Sept 1.
[55]  Bair M, Robinson R, Katon W, Kroenke K (2003) Depression and pain comorbidity: a literature review. Arch Intern Med 163: 2433–2445. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/14609？780. Accessed 2012 Aug 29.
[56]  Mykletun A, Bjerkeset O, ？verland S, Prince M, Dewey M, et al. (2009) Levels of anxiety and depression as predictors of mortality: the HUNT study. Br J Psychiatry 195: 118–125. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/19648？541. Accessed 2012 Aug 6.
[57]  House JS (2001) Social isolation kills, but how and why? Psychosom Med 63: 273–274. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/11292？275. Accessed 2014 May.
[58]  Moulin DE, Clark AJ, Speechley M, Morley-Forster PK (2002) Chronic pain in Canada–prevalence, treatment, impact and the role of opioid analgesia. Pain Res Manag 7: 179–184. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/12518？174. Accessed 2014 May.
[59]  Fishbain D, Cole B, Cutler R et al. (2003) Is Pain Fatiguing? A Structured Evidence Based Review. Pain 4: 51–62. Wiley online website. Available: http://onlinelibrary.wiley.com/doi/10.10？46/j.1526-4637.2003.03008.x/full. Accessed 2012 Aug 29.
[60]  Hardy S, Studenski S (2008) Fatigue predicts mortality in older adults. J Am Geriatr Soc 56: 1910–1914. Wiley online website. Available: http://onlinelibrary.wiley.com/doi/10.11？11/j.1532-5415.2008.01957.x/full. Accessed 2012 Aug 29.
[61]  Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, Botella J (2006) Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods 11: 193–206. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/16784？338. Accessed 2013 March 11.
[62]  Dickersin K (2002) Systematic reviews in epidemiology: why are we so far behind? Int J Epidemiol 31: 6–12. NCBI website. Available: http://www.ncbi.nlm.nih.gov/pubmed/11914？282. Accessed 2014 May.
[63]  Egger M, Smith G, Altman DG (2001) Systematic Reviews in Healthcare: Meta-analysis in context. Second edi. London: BMJ Publishing Group.
[64]  Crombie IK (2001) Widespread body pain and mortality: Prospective population based study. Commentary: An interesting finding, but what does it mean? BMJ 323: 662. BMJ website. Available: http://dx.doi.org/10.1136/bmj.323.7314.6？62. Accessed 2014 May.

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