The auditory steady state response (ASSR) is an oscillatory brain response, which is phase locked to the rhythm of an auditory stimulus. ASSRs have been recorded in response to a wide frequency range of modulation and/or repetition, but the physiological features of the ASSRs are somewhat different depending on the modulation frequency. Recently, the 20-Hz ASSR has been emphasized in clinical examinations, especially in the area of psychiatry. However, little is known about the physiological properties of the 20-Hz ASSR, compared to those of the 40-Hz and 80-Hz ASSRs. The effects of contralateral noise on the ASSR are known to depend on the modulation frequency to evoke ASSR. However, the effects of contralateral noise on the 20-Hz ASSR are not known. Here we assessed the effects of contralateral white noise at a level of 70 dB SPL on the 20-Hz and 40-Hz ASSRs using a helmet-shaped magnetoencephalography system in 9 healthy volunteers (8 males and 1 female, mean age 31.2 years). The ASSRs were elicited by monaural 1000-Hz 5-s tone bursts amplitude-modulated at 20 and 39 Hz and presented at 80 dB SPL. Contralateral noise caused significant suppression of both the 20-Hz and 40-Hz ASSRs, although suppression was significantly smaller for the 20-Hz ASSRs than the 40-Hz ASSRs. Moreover, the greatest suppression of both 20-Hz and 40-Hz ASSRs occurred in the right hemisphere when stimuli were presented to the right ear with contralateral noise. The present study newly showed that 20-Hz ASSRs are suppressed by contralateral noise, which may be important both for characterization of the 20-Hz ASSR and for interpretation in clinical situations. Physicians must be aware that the 20-Hz ASSR is significantly suppressed by sound (e.g. masking noise or binaural stimulation) applied to the contralateral ear.
References
[1]
Galambos R, Makeig S, Talmachoff PJ (1981) A 40-Hz auditory potential recorded from the human scalp. Proc Natl Acad Sci U S A 78: 2643–2647. doi: 10.1073/pnas.78.4.2643
[2]
Kuwada S, Batra R, Maher VL (1986) Scalp potentials of normal and hearing-impaired subjects in response to sinusoidally amplitude-modulated tones. Hear Res 21: 179–192. doi: 10.1016/0378-5955(86)90038-9
[3]
Millman RE, Prendergast G, Kitterick PT, Woods WP, Green GG (2010) Spatiotemporal reconstruction of the auditory steady-state response to frequency modulation using magnetoencephalography. Neuroimage 49: 745–758. doi: 10.1016/j.neuroimage.2009.08.029
[4]
Picton TW, John MS, Dimitrijevic A, Purcell D (2003) Human auditory steady-state responses. Int J Audiol 42: 177–219. doi: 10.3109/14992020309101316
[5]
Linden RD, Campbell KB, Hamel G, Picton TW (1985) Human auditory steady state evoked potentials during sleep. Ear Hear 6: 167–174. doi: 10.1097/00003446-198505000-00008
[6]
Aoyagi M, Kiren T, Kim Y, Suzuki Y, Fuse T, et al. (1993) Optimal modulation frequency for amplitude-modulation following response in young children during sleep. Hear Res 65: 253–261. doi: 10.1016/0378-5955(93)90218-p
[7]
Aoyagi M, Suzuki Y, Yokota M, Furuse H, Watanabe T, et al. (1999) Reliability of 80-Hz amplitude-modulation-following response detected by phase coherence. Audiol Neurootol 4: 28–37. doi: 10.1159/000013817
[8]
Plourde G, Picton TW (1990) Human auditory steady-state response during general anesthesia. Anesth Analg 71: 460–468. doi: 10.1213/00000539-199011000-00002
[9]
Galambos R, Makeig S (1992) Physiological studies of central masking in man. I: The effects of noise on the 40-Hz steady-state response. J Acoust Soc Am 92: 2683–2690. doi: 10.1121/1.404383
[10]
Maki A, Kawase T, Kobayashi T (2009) Effects of contralateral noise on 40-Hz and 80-Hz auditory steady-state responses. Ear Hear 30: 584–589. doi: 10.1097/aud.0b013e3181acfb57
[11]
Kawase T, Maki A, Kanno A, Nakasato N, Sato M, et al. (2012) Contralateral white noise attenuates 40-Hz auditory steady-state fields but not N100m in auditory evoked fields. Neuroimage 59: 1037–1042. doi: 10.1016/j.neuroimage.2011.08.108
[12]
Oda Y, Onitsuka T, Tsuchimoto R, Hirano S, Oribe N, et al. (2012) Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients. PLoS One 7: e39955. doi: 10.1371/journal.pone.0039955
[13]
Rass O, Forsyth JK, Krishnan GP, Hetrick WP, Klaunig MJ, et al. (2012) Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder. Schizophr Res 136: 143–149. doi: 10.1016/j.schres.2012.01.003
[14]
Spencer KM, Salisbury DF, Shenton ME, McCarley RW (2008) Gamma-band auditory steady-state responses are impaired in first episode psychosis. Biol Psychiatry 64: 369–375. doi: 10.1016/j.biopsych.2008.02.021
[15]
Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, et al. (2011) Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia. Schizophr Res 133: 99–105. doi: 10.1016/j.schres.2011.07.020
[16]
Pastor MA, Artieda J, Arbizu J, Marti-Climent JM, Pe？uelas I, et al. (2002) Activation of human cerebral and cerebellar cortex by auditory stimulation at 40 Hz. J Neurosci 22: 10501–10506.
[17]
Tlumak AI, Durrant JD, Delgado RE, Boston JR (2011) Steady-state analysis of auditory evoked potentials over a wide range of stimulus repetition rates: profile in adults. Int J Audiol 50: 448–458. doi: 10.3109/14992027.2011.560903
[18]
Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97–113. doi: 10.1016/0028-3932(71)90067-4
[19]
John MS, Dimitrijevic A, Picton TW (2002) Auditory steady-state responses to exponential modulation envelopes. Ear Hear 23: 106–117. doi: 10.1097/00003446-200204000-00004
[20]
Sarvas J (1987) Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. Phys Med Biol 32: 11–22. doi: 10.1088/0031-9155/32/1/004
[21]
Cohen LT, Rickards FW, Clark GM (1991) A comparison of steady-state evoked potentials to modulated tones in awake and sleeping humans. J Acoust Soc Am 90: 2467–2479. doi: 10.1121/1.402050
[22]
Giraud AL, Lorenzi C, Ashburner J, Wable J, Johnsrude I, et al. (2000) Representation of the temporal envelope of sounds in the human brain. J Neurophysiol 84: 1588–1598.
[23]
Herdman AT, Lins O, Van Roon P, Stapells DR, Scherg M, et al. (2002) Intracerebral sources of human auditory steady-state responses. Brain Topogr 15: 69–86. doi: 10.1023/a:1021470822922
[24]
Liégeois-Chauvel C, Lorenzi C, Trébuchon A, Régis J, Chauvel P (2004) Temporal envelope processing in the human left and right auditory cortices. Cereb Cortex 14: 731–740. doi: 10.1093/cercor/bhh033
[25]
Ross B, Borgmann C, Draganova R, Roberts LE, Pantev C (2000) A high-precision magnetoencephalographic study of human auditory steady-state responses to amplitude-modulated tones. J Acoust Soc Am 108: 679–691. doi: 10.1121/1.429600
[26]
Wong WYS, Stapells DR (2004) Brain stem and cortical mechanisms underlying the binaural masking level difference in humans: an auditory steady-state response study. Ear Hear 25: 57–67. doi: 10.1097/01.aud.0000111257.11898.64
[27]
Draganova R, Ross B, Wollbrink A, Pantev C (2008) Cortical steady-state responses to central and peripheral auditory beats. Cereb Cortex 18: 1193–1200. doi: 10.1093/cercor/bhm153
[28]
Ross B, Draganova R, Picton TW, Pantev C (2003) Frequency specificity of 40-Hz auditory steady-state responses. Hear Res 186: 57–68. doi: 10.1016/s0378-5955(03)00299-5
[29]
Johnson BW, Weinberg H, Ribary U, Cheyne DO, Ancill R (1988) Topographic distribution of the 40 Hz auditory evoked-related potential in normal and aged subjects. Brain Topogr 1: 117–121. doi: 10.1007/bf01129176
[30]
Tlumak AI, Durrant JD, Delgado RE, Boston JR (2012) Steady-state analysis of auditory evoked potentials over a wide range of stimulus repetition rates: profile in children vs. adults. Int J Audiol 51: 480–490. doi: 10.3109/14992027.2012.664289
[31]
Kuriki S, Nogai T, Hirata Y (1995) Cortical sources of middle latency responses of auditory evoked magnetic field. Hear Res 92: 47–51. doi: 10.1016/0378-5955(95)00195-6
[32]
Parkkonen L, Fujiki N, M？kel？ JP (2009) Sources of auditory brainstem responses revisited: contribution by magnetoencephalography. Hum Brain Mapp 30: 1772–1782. doi: 10.1002/hbm.20788
[33]
Ross B, Herdman AT, Pantev C (2005) Stimulus induced desynchronization of human auditory 40-Hz steady-state responses. J Neurophysiol 94: 4082–4093. doi: 10.1152/jn.00469.2005
[34]
Hari R, M？kel？ JP (1988) Modification of neuromagnetic responses of the human auditory cortex by masking sounds. Exp Brain Res 71: 87–92. doi: 10.1007/bf00247524
[35]
Cunningham MO, Halliday DM, Davies CH, Traub RD, Buhl EH, et al. (2004) Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro. J Physiol 559: 347–353. doi: 10.1113/jphysiol.2004.068973
[36]
Roopun AK, Middleton SJ, Cunningham MO, LeBeau FE, Bibbig A, et al. (2006) A beta2-frequency (20–30 Hz) oscillation in nonsynaptic networks of somatosensory cortex. Proc Natl Acad Sci U S A 103: 15646–15650. doi: 10.1073/pnas.0607443103
