One new sesquiterpene and six known compounds were isolated from Dryopteris fragrans (L.) Schot. They were identified as 3- O- β-D-glucopyranosylalbicanol- 11- O- β-D-glucopyranoside ( 1), dihydroconiferylalcohol ( 2), ( E)-3-(4-hydroxyphenyl)acrylic acid ( 3), esculetin ( 4), 5,7-dihydroxy-2-hydroxymethylchromone ( 5), eriodictyol ( 6) and isoorientin ( 7) by UV, MS, 1D-NMR and 2D-NMR spectroscopy. The antifungal activities of the seven isolated compounds were screened. Compounds 2, 3, 4 and 5 showed obvious activities against Microsporum canis and Epidermophyton floccosum.
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