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Molbank  2013 

6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine

DOI: 10.3390/M808

Keywords: Suzuki coupling, 5-fluoro-6-methylpyridin-2-ylboronic acid, 4-chloro-2-iodo-1-(trifluoromethyl)benzene, bis(triphenylphosphine)palladium(II) dichloride (dikis), 1,4-dioxane

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Abstract:

Suzuki coupling reaction of 5-fluoro-6-methylpyridin-2-ylboronic acid (1) with 4-chloro-2-iodo-1-(trifluoromethyl)benzene (2) in the presence of dikis and K 2CO 3 produce C-C coupled new title compound 6-(5-chloro-2-(trifluoromethyl)phenyl)-3-fluoro-2-methylpyridine (3). The structure of the newly synthesized compound has been confirmed by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.

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