We surveyed 10,303 United States physicians on where they obtain pharmacogenomic testing information. Thirty-nine percent indicated that they obtained this from drug labeling. Factors positively associated with this response included older age, postgraduate instruction, using other information sources, regulatory approval/ recommendation of testing, reliance on labeling for information, and perception that patients have benefited from testing. Physicians use pharmacogenomic testing information from drug labeling, highlighting the importance of labeling information that is conducive to practice application.
References
[1]
Stanek, E.J.; Sanders, C.L.; Taber, K.A.; Khalid, M.; Patel, A.; Verbrugge, R.R.; Agatep, B.C.; Aubert, R.E.; Epstein, R.S.; Frueh, F.W. Adoption of pharmacogenomic testing by US physicians: Results of a nationwide survey. Clin. Pharmacol. Ther. 2012, 91, 450–458, doi:10.1038/clpt.2011.306.
[2]
Dodson, C. Knowledge and attitudes concerning pharmacogenomics among healthcare professionals. Pers. Med. 2011, 8, 421–428, doi:10.2217/pme.11.28.
[3]
Bonter, K.; Desjardins, C.; Currier, N.; Pun, J.; Ashbury, F.D. Personalized medicine in Canada: A survey of adoption and practice in oncology, cardiology, and family medicine. Br. Med. J. Open 2011, 1, e000110.
[4]
Zineh, I.; Gerhard, T.; Aquilante, C.L.; Beitelshees, A.L.; Beasley, B.N.; Hartzema, A.G. Availability of pharmacogenomics-based prescribing information in drug package inserts for currently approved drugs. Pharmacogen. J. 2004, 4, 354–358, doi:10.1038/sj.tpj.6500284.
[5]
Frueh, F.W.; Amur, S.; Mummaneni, P.; Epstein, R.S.; Aubert, R.E.; DeLuca, T.M.; Verbrugge, R.R.; Burckart, G.J.; Lesko, L.J. Pharmacogenomic biomarker information in drug labels approved by the United States Food and Drug Administration: Prevalence of related drug use. Pharmacotherapy 2008, 28, 992–998, doi:10.1592/phco.28.8.992.
[6]
US Food and Drug Administration. Table of Pharmacogenomic Biomarkers in Drug Labels. Available online: http://www.fda.gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378.htm (accessed on 27 November 2011).
[7]
Chase, J. What are they thinking? Med. Mark. Med. 2010, 45, 36–37.
[8]
Lai-Goldman, M.; Faruki, H. Abacavir hypersensitivity: A model system for pharmacogenetic test adoption. Genet. Med. 2008, 10, 874–878, doi:10.1097/GIM.0b013e31818de71c.
[9]
American Medical Association. AMA Physician Masterfile. Available online: http://www.ama-assn.org/ama/pub/about-ama/physician-data-resources/physician-masterfile.page (accessed on 14 September 2011).
