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Genes 2013

MicroRNAs and Molecular Mechanisms of Neurodegeneration

DOI: 10.3390/genes4020244

Ilaria Bicchi,Francesco Morena,Simona Montesano,Mario Polidoro,Sabata Martino

Keywords: miRNAs, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic Lateral Sclerosis, Lysosomal Storage Disorders

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Abstract:

During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathways and genetic networks in both plants and animals. MiRNAs have shown to be differentially expressed in brain areas and alterations of miRNAs homeostasis have been recently correlated to pathological conditions of the nervous system, such as cancer and neurodegeneration. Here, we review and discuss the most recent insights into the involvement of miRNAs in the neurodegenerative mechanisms and their correlation with significant neurodegenerative disorders.

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