Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, sensors and prosthesis and for drug delivery systems (for drugs, plant extracts, and nanoparticles). To enhance its wound healing properties was incorporated Casearia sylvestris Swartz extract, whose pharmacological activity includes anti-inflammatory, analgesic, antiseptic, antiulcer, and antitumor due to its casearins and phenols. Results showed the prolonged release of its compounds (35 days) and the mechanism of release is super case II ( ) by Korsmeyer-Peppas model. Although SEM shows different sizes of clusters at the surface, the release is homogeneous through the biomembrane. FTIR shows no interaction between the matrix and the extract, with computation of the presence of some casearins. 1. Introduction Natural rubber latex (NRL) extracted from Hevea brasiliensis (rubber tree) is a colloidal system containing 50% of water, 4-5% of nonrubber (as proteins, lipids, etc.), and 30–45% of rubber particles (cis-1,4-polyisoprene) [1]. When in contact with air, the proteins that stabilize rubber particles get in degradation and lead to latex coagulation [1]. Latex is largely used in artefacts such as gloves, condoms, and baby bottle teats. Proteins in latex also possess angiogenic properties [1], propitiate cell adhesion, and accelerate wound healing [2]. It has been used as prosthesis (vascular [3], tympanum [4], bladder [5], etc.) with no allergy or rejection, demonstrated to be biocompatible and suitable for biomedical application [2]. It has also been used for nanoparticles production [6], delivery system [7], and occlusive biomembrane [8], among others. Casearia sylvestris Swartz (popularly known as “gua？atonga”) is used traditionally to treat diarrhea, skin diseases, snakebite, antiulcer, and so forth [9]. Its bioactive properties are related to its secondary metabolites such as presence of casearins (A–X) and phenols. Related to its pharmacological applications to wound healing, it shows anti-inflammatory [10], antiseptic [11], and analgesic [12] properties; moreover, casearins possess oxygenated backbone related to remarkable cytotoxic and antitumor action [9] and phenol is related to antioxidant activity [13]. Delivery system is important to avoid multiple doses, increasing the patient compliance to the therapy. One possible way to accelerate the tissue repair process is to incorporate the Casearia sylvestris Sw. extract in NRL
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