Purpose. To evaluate the long-term efficacy, accuracy, stability, and safety of hyperopic laser in situ keratomileusis (LASIK) using a 213?nm wavelength solid-state laser. Methods. This prospective noncomparative case series consisted of 34 eyes of 17 patients which underwent hyperopic LASIK using a 213?nm solid-state laser (Pulzar Z1, CustomVis) at an outpatient refractive surgery center in Manila, Philippines. The preoperative and postoperative examinations included uncorrected distance visual acuity (UDVA), subjective manifest refraction, corrected distance visual acuity (CDVA), cycloplegic refraction, slitlamp biomicroscopy, and keratometry ( ). Main Outcome Measures. Accuracy, efficacy, stability, and safety of the refractive procedure. Results. Mean follow-up was months. At the end of follow-up, 26.47% had a UDVA of 20/20 and 94.12% had a UDVA of ≥20/40. Manifest refractive spherical equivalent (MRSE) was within ±0.50?D of the target refraction in 55.88% and within ±1.0?D in 85.30% of the study eyes. Refractive stability was noted in the 1st postoperative month while hyperopic regression was noted after the 3rd postoperative year. No eye lost more than 2 lines of CDVA. Conclusion. Our results show that the 213?nm solid state laser system is safe, effective, accurate, and predictable for the treatment of hyperopia. 1. Introduction Laser in situ keratomileusis is approved by the US Food and Drug Administration (FDA) for the treatment of myopia, hyperopia, and astigmatism and has been a popular choice among refractive surgeons for almost 2 decades now [1, 2]. Hyperopic LASIK consists of an annular zone of ablation to cause a relative flattening of the corneal periphery and a concomitant relative steepening of the center (optical zone) to achieve the desired refractive effect. Early attempts to correct hyperopia included techniques such as hexagonal keratotomy, thermokeratoplasty, keratophakia, and keratomileusis but have met with only limited success. With the advent of the excimer laser technology, reshaping of the corneal surface to a desired contour with submicron precision and reproducibility became a reality [3]. With the prototype ophthalmic excimer lasers, the visual and refractive outcomes of LASIK for hyperopia were less predictable due to challenges arising from the need to use larger ablation diameters and the relative difficulty to deliver uniformly distributed laser energy in ablation zones larger than 6?mm [1]. Newer models have permitted larger ablation diameters and the development of various microkeratomes facilitated the
References
[1]
N. A. Sher, “Hyperopic refractive surgery,” Current Opinion in Ophthalmology, vol. 12, no. 4, pp. 304–308, 2001.
[2]
D. Zadok, F. Raifkup, D. Landau, and J. Frucht-Pery, “Long-term evaluation of hyperopic laser in situ keratomileusis,” Journal of Cataract and Refractive Surgery, vol. 29, no. 11, pp. 2181–2188, 2003.
[3]
D. P. S. O'Brart, “The status of hyperopic laser-assisted in situ keratomileusis,” Current Opinion in Ophthalmology, vol. 10, pp. 247–252, 1999.
[4]
S. Esquenazi and A. Mendoza, “Two-year follow-up of laser in situ keratomileusis for hyperopia,” Journal of Refractive Surgery, vol. 15, no. 6, pp. 648–652, 1999.
[5]
R. U. Desai, A. Jain, and E. E. Manche, “Long-term follow-up of hyperopic laser in situ keratomileusis correction using the Star S2 excimer laser,” Journal of Cataract and Refractive Surgery, vol. 34, no. 2, pp. 232–237, 2008.
[6]
R. Y. Choi and S. E. Wilson, “Hyperopic laser in situ keratomileusis: primary and secondary treatments are safe and effective,” Cornea, vol. 20, no. 4, pp. 388–393, 2001.
[7]
R. Cobo-Soriano, F. Llovet, F. González-López, B. Domingo, F. Gómez-Sanz, and J. Baviera, “Factors that influence outcomes of hyperopic laser in situ keratomileusis,” Journal of Cataract and Refractive Surgery, vol. 28, no. 9, pp. 1530–1538, 2002.
[8]
N. S. Tsiklis, G. D. Kymionis, G. A. Kounis et al., “One-year results of photorefractive keratectomy and laser in situ keratomileusis for myopia using a 213?nm wavelength solid-state laser,” Journal of Cataract and Refractive Surgery, vol. 33, no. 6, pp. 971–977, 2007.
[9]
T. Sanders, T. Pujara, S. Camelo et al., “A comparison of corneal cellular responses after 213-nm compared with 193-nm laser photorefractive keratectomy in rabbits,” Cornea, vol. 28, no. 4, pp. 434–440, 2009.
[10]
N. S. Tsiklis, G. D. Kymionis, G. A. Kounis, I. I. Naoumidi, and I. G. Pallikaris, “Photorefractive keratectomy using solid state laser 213?nm and excimer laser 193?nm: a randomized, contralateral, comparative, experimental study,” Investigative Ophthalmology and Visual Science, vol. 49, no. 4, pp. 1415–1420, 2008.
[11]
A. F. Felipe, A. L. D. Agahan, T. L. Cham, and R. P. Evangelista, “Photorefractive keratectomy using a 213?nm wavelength solid-state laser in eyes with previous conductive keratoplasty to treat presbyopia: early results,” Journal of Cataract and Refractive Surgery, vol. 37, no. 3, pp. 518–524, 2011.
[12]
G. T. Dair, W. S. Pelouch, P. P. Van Saarloos, D. J. Lloyd, S. M. Paz Linares, and F. Reinholz, “Investigation of corneal ablation efficiency using ultraviolet 213-nm solid state laser pulses,” Investigative Ophthalmology and Visual Science, vol. 40, no. 11, pp. 2752–2756, 1999.
[13]
G. T. Dair, R. A. Ashman, R. H. Eikelboom, F. Reinholz, and P. P. Van Saarloos, “Absorption of 193- and 213-nm laser wavelengths in sodium chloride solution and balanced salt solution,” Archives of Ophthalmology, vol. 119, no. 4, pp. 533–537, 2001.
[14]
F. Llovet, A. Galal, J. Benitez-del-Castillo, J. Ortega, C. Martin, and J. Baviera, “One-year results of excimer laser in situ keratomileusis for hyperopia,” Journal of Cataract and Refractive Surgery, vol. 35, no. 7, pp. 1156–1165, 2009.
[15]
G. O. Waring III, B. Fant, G. Stevens et al., “Laser in situ keratomileusis for spherical hyperopia and hyperopic astigmatism using the NIDEK EC-5000 excimer laser,” Journal of Refractive Surgery, vol. 24, no. 2, pp. 123–136, 2008.
[16]
P. D. Jaycock, D. P. S. O'Brart, M. S. Rajan, and J. Marshall, “5-Year follow-up of LASIK for hyperopia,” Ophthalmology, vol. 112, no. 2, pp. 191–199, 2005.
[17]
J. Alió, A. Galal, M. J. Ayala, and A. Artola, “Hyperopic LASIK with Esiris/Schwind technology,” Journal of Refractive Surgery, vol. 22, no. 8, pp. 772–781, 2006.
[18]
G. M. Kezirian, C. R. Moore, K. G. Stonecipher et al., “Four-year postoperative results of the US ALLEGRETTO WAVE clinical trial for the treatment of hyperopia,” Journal of Refractive Surgery, vol. 24, no. 4, pp. S431–S438, 2008.
[19]
S. G?ker, H. Er, and C. Kahvecioglu, “Laser in situ keratomileusis to correct hyperopia from +4.25 to +8.00 Diopters,” Journal of Refractive Surgery, vol. 14, no. 1, pp. 26–30, 1998.
[20]
R. L. Nepomuceno, B. S. Boxer Wachler, J. M. Kim, R. Scruggs, and M. Sato, “Laser in situ keratomileusis for hyperopia with the LADARVision 4000 with centration on the coaxially sighted corneal light reflex,” Journal of Cataract and Refractive Surgery, vol. 30, no. 6, pp. 1281–1286, 2004.
[21]
A. J. Kanellopoulos, J. Conway, and L. H. Pe, “LASIK for hyperopia with the wavelight excimer laser,” Journal of Refractive Surgery, vol. 22, no. 1, pp. 43–47, 2006.
[22]
C. J. Argento and M. J. Cosentino, “Comparison of optical zones in hyperopic laser in situ keratomileusis: 5.9?mm versus smaller optical zones,” Journal of Cataract and Refractive Surgery, vol. 26, no. 8, pp. 1137–1146, 2000.
[23]
K. E. Lee, B. E. K. Klein, and R. Klein, “Changes in refractive error over a 5-year interval in the Beaver Dam eye study,” Investigative Ophthalmology and Visual Science, vol. 40, no. 8, pp. 1645–1649, 1999.
[24]
M. Guzowski, J. J. Wang, E. Rochtchina, K. A. Rose, and P. Mitchell, “Five-year refractive changes in an older population: the Blue Mountains Eye Study,” Ophthalmology, vol. 110, no. 7, pp. 1364–1370, 2003.
[25]
P. S. Hersh and B. S. Reem Abbassi, “Surgically induced astigmatism after photorefractive keratectomy and laser in situ keratomileusis,” Journal of Cataract and Refractive Surgery, vol. 25, no. 3, pp. 389–398, 1999.
[26]
J. M. Davidorf, F. Eghbali, T. Onclinx, and R. K. Maloney, “Effect of varying the optical zone diameter on the results of hyperopic laser in situ keratomileusis,” Ophthalmology, vol. 108, no. 7, pp. 1261–1265, 2001.
[27]
M. A. El-Helw and A. M. Emarah, “Predictability and stability of refraction with increasing optical zone diameter in hyperopic LASIK,” Clinical Ophthalmology, vol. 4, no. 1, pp. 455–458, 2010.
[28]
I. Anderson, D. R. Sanders, P. Van Saarloos, and W. J. Ardrey IV, “Treatment of irregular astigmatism with a 213?nm solid-state, diode-pumped neodymium:YAG ablative laser,” Journal of Cataract and Refractive Surgery, vol. 30, no. 10, pp. 2145–2151, 2004.