The study presents the synthesis of nano-thiamine hydrochloride structure (NTH) using sol-gel method by hydrolysis of tetraethyl orthosilicate with ethanol and water mixture as silica source and nitric acid as catalyst support in which thiamine hydrochloride nanocrystals were dispersed in the silica glassy matrix. The synthesized nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential thermal analysis (DTA). The morphological observation of the SEM results reveals that the nano-thiamine hydrochloride composites are in the range of 5–15？nm in size. 1. Introduction Nanomaterials with an average grain size in the range from 1 to 20？nm have attracted research interest for more than a decade since their physical properties are greatly influenced by controlling the material at atomic scale [1]. In recent years much attention has been concentrated on metal nanocatalysts due to their novel characteristics and wide application in numerous reactions [2–4]. Many methods have been developed to control the size of nanoparticles such as Langmuir Blodgett films [5], vesicles [6], and reverse microemulsion [7]. The chemical and physical properties exhibited by these materials depend, among others, on both the composition and the degree of the homogeneity. Therefore different synthesis strategies have been developed [8, 9], such as coprecipitation [10], flame hydrolysis, microwave radiation, impregnation, and chemical vapor deposition. The sol-gel method has demonstrated the high potential to control the bulk and surface properties of the oxides [11–13]. Some of the advantages of the sol-gel method are its versatility and the possibility to obtain high purity materials, the provision of an easy way for the introduction of trace elements, allowance of the synthesis of special materials, and energy saving by using low processing temperature. Additionally, nonhydrolytic sol-gel methods have been also reported in the literature [14]. In this work, a novel sol-gel method to the synthesis of nano-thiamine hydrochloride composite (NTHC) is presented and the composite was analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential thermal analysis (DTA). 2. Experimental 2.1. Materials and Methods Thiamine hydrochloride [C12H17ClN4OS·HCl (VB1)] was purchased from “Novin Kavosh Mamatir Company in Arak, Iran”. Tetraethyl orthosilicate
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