The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400？mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21？days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures. 1. Introduction At present there is an extensive growth in the field of herbal mixtures, and these mixtures are gaining popularity both in developing and developed countries because of their natural origin and less side effects. Many traditional medicines are derived from medicinal plants and minerals which are used for the treatment of different chronic diseases like diabetes, asthma, and so forth [1]. Major hindrance in amalgamation of herbal medicine in modern medical practices is lack of scientific and clinical data proving their efficacy and safety. There is a need for conducting clinical research in herbal mixtures, developing simple bioassays for biological standardization, pharmacological and toxicological evaluation, and developing various animal models for toxicity and safety evaluation. It is also important to establish the active components of these herbal extracts [2]. Diabetes is a metabolic disorder characterized by increased fasting and postprandial blood sugar levels. The prevalence of diabetes is likely to be increased by 35% [2]. It may be projected from 15 million in 1995 to 57 million in 2025 [3]. In the present study eleven plants (cited below) have been selected for preparation of five mixtures. The Ferula assa-foetida is found to reduce the body weight of alloxan-induced albino rats [4]. The Annona squamosa extract brings blood
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