Background. We wanted to verify retrospectively the proportion of patients with psoriatic arthritis who were in remission after 1 year of continuous therapy with either etanercept or adalimumab. Remission was defined as the absence of both clinical and contrast-enhanced ultrasound (CEUS) findings suggestive of joint inflammation. Patients and Methods. The data of twenty-five patients with psoriatic arthritis were available for the clinical and CEUS evaluations before and after 1 year of continuous therapy with etanercept or adalimumab. The count of swollen (ACR66), tender (ACR68), and active inflamed joints (AJC) was used to measure the severity of joint involvement. PASI was used to score the severity of psoriasis. HAQ, DLQI, VAS pain, and VAS itching were administered to each patient before starting therapy and every 3 months, up to 1 year. Results. Eight (32%) out of twenty-five patients were in remission after 1 year of therapy with etanercept or adalimumab. A significant reduction of all clinical variables analysed was seen during the course of therapy. Conclusion. Although a significant proportion of patients achieved remission of arthritis after 1 year of effective anti-TNF therapy, the majority of them continued to have either clinical or CEUS findings suggestive of persistence of joint inflammation. 1. Introduction An inflammatory involvement of the axial and/or peripheral joints has been reported to occur in a percentage ranging from 6% to 39% of psoriatic patients [1]. More and more data clearly indicate that psoriatic arthritis (PsA) must be considered a serious disease with the risk of permanent joint deformity with disabling consequences [2]. In the majority of cases, skin manifestations precede by several years signs and symptoms of arthritis that in turn can have a long paucisymptomatic course [3]. Therefore dermatologists play a privileged role in suspecting PsA at an early stage and refer selected patients to a consultant rheumatologist to confirm the presence of inflammatory arthritis. The diagnosis of PsA primarily relies on highlighting a musculoskeletal inflammatory condition (joint, spine, or entheseal) [3]. The articular disease can be classified as “psoriatic” if CASPAR criteria are satisfied [4]. As regards the diagnosis and followup of PsA, they have been improved in recent years thanks to the introduction of magnetic resonance imaging (MRI) and ultrasound (US). These imaging techniques have proven to be more sensitive than traditional X-rays, mainly in the diagnosis of early PsA [5, 6]. With regard to the sensitivity of US
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