Objective. To assess the efficacy of a low-dose oral isotretinoin in the treatment of plane warts. Patients and Methods. Thirty-one patients with recalcitrant facial plane warts were enrolled. A cumulative dose of 30？mg/kg for two months of treatment was calculated; this was equal to a mean of 0.5？mg/kg/day. Each patient was seen every two weeks during the treatment period. Response to treatment was either complete or no response. Patients with complete response were followed up monthly for four months to record the relapse rate. Results. Twenty-six patients completed the study; their ages range from 5 to 35 with a mean ± SD years. Fifteen (57.69%) patients were females and eleven (42.30%) were males. Nineteen (73.07%) patients showed complete response and seven (26.92%) patients showed no response at the end of two months of therapy. The difference was statistically significant; P value . Fifteen (78.94%) out of nineteen patients, who had complete response, were still free from warts at the end of four-month followup. Conclusion. Oral isotretinoin is effective in the treatment of recalcitrant facial plane warts. 1. Introduction Plane warts are smooth, flat, or slightly elevated and are usually skin coloured or greyish yellow but may be pigmented. They are round or polygonal in shape and vary in size from 1 to 5？mm or more in diameter. They usually affect the face and the dorsa of the hands [1]. Many modalities of therapy had been used with variable success, for example, topical retinoic acid [2], imiquimod [3], and 5-fluorouracil [4]. Systemic isotretinoin has been used to treat severe acne vulgaris. However, isotretinoin also represents a potentially useful choice in many dermatologic diseases such as psoriasis, pityriasis rubra pilaris, condylomata acuminata, skin cancers, and rosacea [5]. The aim of the present study is to evaluate the effectiveness of a low-dose oral isotretinoin in the treatment of plane warts. 2. Patients and Methods This was an open therapeutic trial conducted at the department of Dermatology and Venereology, Baghdad Teaching hospital from August 2009 to March 2011. Thirty-one patients with facial plane warts were included in the study. All cases were resistant to other forms of therapy and were without any treatment for at least two months before beginning the study. All female patients enrolled in the study were unmarried. Children under 5 years and pregnant women were excluded from the study. A full interrogation and explanation about the nature of the disease and the possible side effects of the treatment were performed to
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