Objectives. The aim of the present study was to review the published literature in order to identify relevant studies for inclusion and to determine whether there was any evidence on the clinical effectiveness of selected desensitizing toothpastes, calcium sodium phosphosilicate (CSPS), amorphous calcium phosphate (ACP), nanohydroxyapatite, and casein phosphopeptide-amorphous calcium phosphate (tooth mousse) on reducing dentine hypersensitivity (DH). Materials and Methods. Following a review of 593 papers identified from searching both electronic databases (PUBMED) and hand searching of relevant written journals, only 5 papers were accepted for inclusion. Results. Analysis of the included studies (3 CSPS and 2 ACP) would suggest that there may be some benefit for patients using these products for reducing DH. No direct comparative studies were available to assess all these products under the same conditions neither were there any comparative randomised controlled studies that compared at least two of these products in determining their effectiveness in treating DH. Conclusions. Due to the small number of included studies, there are limited clinical data to support any claims of clinical efficacy of these OTC products. Further studies are therefore required to determine the efficacy of these products in well-controlled RCT studies with a larger sample size. 1. Introduction Dentine hypersensitivity (DH) is a worldwide clinical condition that has been reported to have an impact on the adult population at various stages during their lifetime. Recently, several investigators [1, 2] reported on the negative effects of DH on a patient’s quality of life (oral health-related quality of life, OHRQoL). The prevalence of DH reported in the literature varies depending on the methodology utilized to collect data; however, it has been reported to affect up to 74% of the population although several investigators have reported that this figure may be higher in individuals with periodontal disease [3, 4]. According to a number of investigators [5, 6], DH appears to have been previously underreported by patients as well as underdiagnosed by dentists which therefore may lead to the problem being ignored and undertreated. Diagnosis of DH can be problematic but from the clinician’s viewpoint, it is essential to exclude all other clinical conditions that have a similar pain history. The management of generalized mild or moderate DH has traditionally been achieved via the use of over-the-counter (OTC) desensitising products through a clinician’s recommendations which depend on
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