A method was established to monitor organic reactions by micellar capillary electrokinetic chromatography (MEKC). After optimizing conditions such as the composition of the solvents, the surfactant, and the apparent pH (pH*) of the system, the method was utilized to analyze the reaction of glycidyl methacrylate (GMA) and allyl amine. The main products were identified in the electropherograms. The reaction procedure was monitored in real time. This method was found to have common applicability, being able to separate and detect nonaqueous soluble, nonionic, and low-UV-Vis absorbance compounds. It provides a rapid and low-cost way to understand organic reactions and to direct synthesis works. 1. Introduction Capillary electrophoresis (CE) is a rapid and high-performance method of separation and analysis [1]. It possesses advantages such as high efficiency, high speed, ease to be automated, low sample consumption, low cost, and multimode availability. After decades of development, CE plays important roles in the fields of chemistry, biology, pharmaceutical, environment, toxicology, medicine, and forensic chemistry [2–10]. It is very important to analyze the products of an organic reaction, as well as to monitor the related kinetics or reaction procedure. The related methods are mainly focused on elemental analysis, nuclear magnetic resonance (NMR), mass spectrometry (MS), infrared radiation (IR), and ultraviolet visible (UV-Vis) spectrometry. Many of these methods are usually obstructed by the limited purification of the products from complex reactions. A chromatographic method (gas or liquid) can be used to simultaneously separate and detect complex samples. It enables the analysis and monitoring of organic reactions in real time [11]. CE is a method which can analyze charged analytes in aqueous solution. CE could also be an important method to analyze chemical reactions, playing a role in the research of reaction kinetics [5, 12], asymmetric transformation of amino acids [13, 14], catalytic oxidation [15], assembling of nanoparticles [16], protein interaction [17], and polymerase chain reaction (PCR) [18–20]. One of the modes of CE, micellar electrokinetic chromatography (MEKC), introduced surfactants as pseudostationary phases. In such a CE operation, analytes are not only separated in accordance with their mobility but also based on their distributions in the pseudostationary phases. As a result, neutral compounds without any charge could also be separated in that case when they appear in different concentrations in the micelle. In this paper, we give
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